63 results about "Endocarditis" patented technology

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

The invention relates to an analysis method and a system of metagenome data. According to the invention, a preliminary species identification result of a sample is obtained on the basis of a k-Mer algorithm, a part or all of supporting sequences are extracted on the basis of the preliminary species identification result, and the preliminary species identification result is verified by using a blast algorithm to judge whether the preliminary species identification result is a reported detected species or not. The method and system disclosed by the invention can lower false positivity, quickly and accurately obtain the reported detected species of the sample in a short time, and are compatible with various mainstream sequencing platforms, thereby being suitable for second-generation sequencing technologies and third sequencing technologies; the method and system of the invention can also accurately identify drug-resistant genes and drug-resistant mutation sites of the sample and map thedrug-resistant genes and the drug-resistant mutation sites of the sample to the reported detected species. Furthermore, the system disclosed by the invention can be used for identifying pathogenic microorganisms, especially endocarditis pathogens to overcome the defect that the endocarditis pathogens are difficultly cultured.

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

A compound of formula (I) wherein R<1> and R<2> are as defined in the description, R<2> being an aromatic group, useful in the treatment and condition selected from the group consisting of the group meningitis and salpingitis, septic shock, disseminated intravascular coagulation, and / or adult respiratory distress syndrome, acute or chronic inflammation, arthritis, cholangitis, colitis, encephalitis, endocarditis, glomerulonephritis, hepatitis, myocarditis, pancreatitis, pericarditis, reperfusion injury, vasculitis, acute and delayed hypersensitivity, graft rejection, and graft-versus-host disease, auto-immune diseases including Type 1 diabetes mellitus and multiple sclerosis, periodonate diseases, interstitial pulmonary fibrosis, cirrhosis, systemic sclerosis, keloid formation tumors which produce IL-1 as an autocrine growth factor, cachexia, Alzeimer's disease, percussion injury, depression, atherosclerosis, osteoporosis in a mammal, including a human.

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn s disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

The invention relates to a cefathiamidine hydrate, a preparation method thereof and application thereof. The crystalline hydrate has high storage stability, and is applicable in preparing medicaments for treating or preventing gram positive or negative bacteria sensitive bacteria, infections of human or animal respiratory system, liver and biliary system, five sense organs and urogenital system, bone and joint infection and soft skin tissue infection caused by the gram positive or negative bacteria sensitive bacteria, and diseases such as endocarditis, ichorrhemia, meningitis and the like.

The invention relates to a cefpiramide sodium hydrate and a preparation method and application thereof. The cefpiramide sodium hydrate has high storage stability, and is applicable to the preparation of medicines for treating or preventing diseases of the human being or animals caused by gram-positive or gram-negative sensitive bacteria, such as respiratory system diseases, hepatobiliary system diseases, five-sense organ diseases, urinary tract infection, celiac infection, pelvic infection, ichorrhemia, skin tissue infection, bone and joint infections, endocarditis and cephalomeningitis.

The invention relates to a lignin compound that could prevent yellow staphylococcal bacteria and B type hemolytic streptococcus, and the medicine combination of the compound. The invention of lignin Morgan dandehon herb acid A and Rufescidride has obviously effect restraining yellow staphylococcal and B type hemolytic streptococcus. It is also respected to prevent the diseases caused by them, like boil, blain, toxicity epidermis necrolysis, pneumonia, etc.

The present invention provides compositions, medicaments, and methods for the treatment or prophylaxis of conditions associated with the binding of Streptococcus mutans to teeth. Specifically, the present invention provides a method for preventing dental caries and infective endocarditis in a subject by treating the subject's oral cavity with a composition or medicament comprising the competence stimulating peptide (CSP) of the causative bacterium, which inhibits the ability of the said bacteria to attach to the surface of teeth. Novel anti-caries compositions using the CSP are also disclosed.

This invention relates to Ligulatrovine A separated from Ligularia actroviolacea that can prevent and treat diseases related to Staphylococcus aureus and beta hemolytic streptococcus, its pharmaceutical salts and drug composition. Ligulatrovine A has significant inhibitive effect on Gram-positive bacteria, and can prevent and treat diseases such as boil, pustule, pneumonia, osteomyelitis, acute myocarditis, endocarditis, meningitis, mastitis, cystitis, pelvic inflammation, urinary inflammation, prostatitis, bacteremia, or abscess in muscle, skin, urogential region or central nervous system caused by Gram-positive bacteria infection.

The invention relates to a cefathiamidine hydrate and a preparation method and application thereof. The crystalline hydrate has high storage stability, is suitable for preparing bacteria sensitive to Gram-positive or negative bacteria, and is applied to the preparation of medicaments for treating or preventing infection of respiratory systems, liver and gall bladder systems, five sense organs, urogenital systems, bones, joints and skin soft tissues as well as diseases such as endocarditis, septicemia, brain fever and the like of human beings or animals caused by bacteria which are sensitive to Gram-positive or negative bacteria.

A polynucleotide encoding a polypeptide which lowers the glucose side chain amount in a serotype-specific polysaccharide antigen of Streptococcus mutans; novel Streptococcus mutans strain having the above polynucleotide; an antibody specific to this Streptococcus mutans strain; and a method of detecting the above-described Streptococcus mutans strain occurring in a subject sample. According to this method, it is possible to examine the presence or absence of Streptococcus mutans of an untypable serotype in a subject sample to thereby specify a subject having a high risk of the onset of infective endocarditis.

The invention relates to a cefotetan disodium hydrate and a preparation method and application thereof. The cefotetan disodium hydrate has high storage stability, and is applicable to the preparation of medicines for treating or preventing diseases of the human being or animals caused by gram-positive or gram-negative sensitive bacteria, such as respiratory system diseases, hepatobiliary system diseases, five-sense organ diseases, urinary tract infection, celiac infection, pelvic infection, ichorrhemia, skin tissue infection, bone and joint infections, cephalomeningitis and endocarditis.

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

The invention discloses a flavonoid glycoside and medical salt and application to prevent Micrococcus pyogenes and beta hemolytic streptococcus, which is characterized by the following: preventing pustule, toxic epidermal decay, acute myocarditis, cystitis, cervicitis and tumour of neutral nerve system; fitting for treating prostatitis, pneumococcus, medullitis and knuckle disease.

The invention discloses a peripheral-leakage prevention stent device with a covering film, a processing method, a skirt hem wrinkling method and a cardiac valve. The stent device comprises a stent, and further comprises a flexible skirt hem. The skirt hem has a spreading state and a piling state, when the skirt hem is in the spreading state, the skirt hem stretches axially and surrounds the outerperiphery of the stent before releasing, and when the skirt hem is in the piling state, the skirt hem is driven by deformation generated when the stent is released and folded and piled in the axial direction of the released stent to form an annular peripheral-leakage prevention blocking part. According to the device, a peripheral-leakage prevention technology is adopted, so that the interventionalstent is more identical to the inner wall of the blood vessel, the stent is not easily displaced and is more stable, the range of applicable people is expanded, the additional risk of an operation isreduced, and complications such as peripheral leakage and thrombus are prevented and treated; better hemodynamic performance is provided, the climbing and covering function of endothelial cells of the host is enhanced, the occurrence probability of endocarditis is reduced, and normal blood supply functions of the heart and blood vessels are restored.

The invention relates to cefathiamidine monocrystal, a preparation method, use and a composition thereof. The cefathiamidine monocrystal disclosed by the invention is prepared by comprising the following steps of: adding three solvents, namely ethanol, water and acetone, into a clean conical flask in any sequence according to any proportion, wherein the volume ratio of ethanol, water to acetone is (4-10):1:(0.05-3.67), during, before or after adding various solvents, adding cefathiamidine, dissolving at room temperature, and preparing cefathiamidine solution with the concentration of 0.05-0.5 g / ml; sealing by using a plastic film, and pricking a plurality of small holes on the plastic film; storing at 0-15 DEG C; and beginning to generate tiny crystals after about 48 h, and then obtaining cefathiamidine monocrystal after above 96 h. The preparation method disclosed by the invention is simple and convenient for operation and simple in equipment; the prepared monocrystal is good in stability; the cefathiamidine monocrystal composition disclosed by the invention is a composition composed of monocrystal and pharmaceutically acceptable carriers, preferably injection; the cefathiamidine monocrystal disclosed by the invention can be used for preparing medicines for treating respiratory tract infection, biliary tract infection, urinary tract infection, wound and surgical infection, skin and soft tissue infection, gynaecological infection, ear-nose-throat infection, endocarditis, blood poisoning, pneumonia and meningitis.

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

The invention relates to a sodium fusidate powder-injection pharmaceutical composition for injection and a preparation method. Specifically, the invention belongs to the technical field of medicines, relates to a medicine which can be used for treating various infections such as osteomyelitis, sepsis, endocarditis, repeatedly infected cystic fibrosis, pneumonia, skin and soft tissue infections, surgical and traumatic infections and the like caused by various sensitive bacteria, especially staphylococcus, and particularly relates to a pharmaceutical composition such as a freeze-dried powder injection prepared by taking sodium fusidate as an active component. The invention also relates to a preparation method of the pharmaceutical composition. In an implementation scheme, the invention relates to a sodium fusidate powder-injection pharmaceutical composition for injection, which comprises sodium fusidate, a neutral amino acid and an alkaline amino acid. The pharmaceutical composition has excellent pharmaceutical properties.

A method of extracting globulin from land molluscs and application thereof belong to biological field. The invention is to make a health-care food containing high-purity globulin and high calorie by matching extracted immunoglobulin, free radical active enzymes and coenzyme with fresh lean pork, beef etc. Treated by non-drug therapy such as chemotherapy, radiotherapy, after having food therapy by the food, the patients having leukaemia have the immune antigen resistance strengthened, the physiologic equilibrium maintained, cell mutation removed and normal cellular functions maintained. The food especially has unique functions to alimentary tract endocarditis and dysfunction caused by chemotherapy and radiotherapy, in supplying high protein and calorie, relieving leukaemia symptoms and physical symptoms of the patients. The inventive immune globulin has certain curative effect on patients having asthma and AIDS, people having low immunity and patients having tumour and lowered immunity caused by chemotherapy and radiotherapy, meanwhile, can be drunk by normal healthy people for supplying protein and calorie, strengthening constitution and preventing diseases.

The invention discloses a traditional Chinese medicine for treating endocarditis.The traditional Chinese medicine is prepared from herb of common peganum, peach leaf, balsamiferou blumea herb, fiveleaf akebia root, root of Yunnan larkspur, shinyleaf pricklyash root, nipponian greenbrier rhizome and root, intermediate torricellia root and leaf, green fig root, whitestem serpentroot root, winterberry euonymus herb, asiatic moonseed rhizome, stem of finet clematis, stem or leaf of fortune euonymus, miquel brookweed root and leaf, ceylon leucas herb, root of multibract raspberry, root of shortlobe ligusticum, Indo-Chinese rat snake, eriocarpous glochidion leaf, starflowerlike loosestrife root or herb and integrifolious chloranthus herb or root.The purely natural Chinese herbal medicines are used as raw materials, both symptoms and root caused are treated, the treatment effect is definite, no side or toxic effect is caused, and relapse does not occur easily.

The invention provides a method for applying a dual high-resolution melting curve technology to detect Bartonella. By the adoption of the method, Bartonella henselae and Bartonella Quintana can be simultaneously and quickly detected, and effective measures are provided for early-stage rapid diagnosis, monitoring, epidemiological investigation and the like of a series of diseases including endocarditis caused by the Bartonella henselae and Bartonella Quintana.

The invention discloses a traditional Chinese medicine preparation for treating infective endocarditis and a preparation method and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine preparation comprises raw materials of effective constituents as follows: rhubarb, pilular adina herbs, paulownia flowers, pondweed, Lingnan garcinia, Malabar spinach, ligustrum leaves, jujube bark, hops, philippine violet herbs, common dysosmatis rhizomes and roots, malt, winter jasmines, cassia twigs, camphor leaves and Chinese angelica. Selected medicinal materials of the traditional Chinese medicine preparation are properly compatible, and the preparation conforms to traditional Chinese medicine and modern medicine theories, has functions of relieving swelling and pain, clearing away heat, removing toxins, realizing sterilization, diminishing inflammations and realizing nourishing and tonifying effects, is convenient to take, has the good absorbing effect, is free of adverse, toxic and side effects, is clinically verified to have very good relieving and treatment effects on the infective endocarditis and is suitable for clinical treatment of the infective endocarditis and nursing popularization and application.

The invention discloses a vascular stent prosthesis for preventing peripheral leakage from a creased skirt edge, a processing method and a skirt edge creasing method. The vascular stent prosthesis comprises a stent and a flexible skirt edge, wherein the skirt edge has a spreading state and a stacking state; in the spreading state, the skirt edge axially extends and encircles the periphery of the stent before release; in the stacking state, the skirt edge is driven under the deformation effect during release of the stent and folded and stacked in the axial direction of the released stent to form an annular circumferential leakage blocking part; the vascular stent prosthesis is also provided with a traction rope which only penetrates through the skirt edge, and the traction rope is linked with the radial deformation when the stent is released so as to drive the skirt edge to switch into the stacking state. According to the vascular stent prosthesis, a peripheral leakage prevention technology is adopted for ensuring that the interventional stent is better matched with the inner wall of a blood vessel, the stent is unlikely to move and more stable, the range of the suitable crowds is enlarged, the additional risk of an operation is reduced, and complications such as peripheral leakage, thrombus and the like are prevented. Better hemodynamic performance is provided, the climbing function of host endothelial cells is improved, the occurrence probability of endocarditis is decreased, and the normal blood supply function of the heart and blood vessels recovers.

The invention discloses a new indication of a cefoperazone sodium and sulbactam sodium drug preparation for treating infectious endocarditis. Cefoperazone sodium provided through a specific raw material production process is extremely low in impurity content and significant in pharmaceutical effect, the quality of a preparation product is improved advantageously, the safety and effectiveness of the preparation product are ensured, and application to the aspect of preparing a drug for treating infectious endocarditis is realized.

The invention discloses a cefoxitin sodium new chemical compound entity and a composition thereof, the cefoxitin sodium new chemical compound storage has better stability less hygroscopicity, and is suitable for preparation of drugs for the treatment or prevention of human or animal respiratory tract infection, endocarditis, peritonitis, pyelonephritis, urinary tract infection, blood poisoning and bone, joint, skin and soft tissue infection and the like caused by gram positive or negative bacteria sensitive bacteria.

The invention discloses the application of sophocarpine and medical salts thereof in medicines treating viral dilated cardiomyopath, viral hypertrophic cardiomyopathy, viral coronaritis, viral pericarditis, viral endocarditis, viral valvulitism, pneumonia, bronchitis, hepatitis, encephalitis, meningitis, pancreatitis, epidemic myalgia and epidemic pleurodynia which are caused by Coxsackie B virus. The sophocarpine and the medical salts thereof which are taken as medicines for treating all related internal organ diseases caused by Coxsackie B virus can increase the cure rate, reduce the death rate and cause no obvious cytotoxic effect. Meanwhile, the sophocarpine is applicable to the industrialized production due to the rich medical herb resources, simple and convenient preparation and low cost.

According to certain embodiments, the present disclosure provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds a Staphylococcus species target antigen and a second antigen binding domain that binds a complement component. In certain embodiments, the bispecific antigen-binding molecules of the present disclosure are capable of binding to the Staphylococcus species target antigen with an EC50 of about 10 nM or less, and / or are capable of promoting complement deposition on the Staphylococcus species with an EC50 of about 10 nM. The antibodies of the disclosure are useful for treating diseases in which inhibition or reduction of the growth of a Staphylococcus species is desired and / or therapeutically beneficial, for example, for treating staphylococcal infections including a skin infection, cellulitis, pneumonia, meningitis, urinary tract infection, toxic shock syndrome, endocarditis, osteomyelitis, bacteremia, or sepsis, or for preventing or treating a staphylococcus infection that occurs as a result of a surgical procedure.