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Antibacterial dentin adhesive and preparation method thereof

A technology of adhesives and dentin, applied in dental preparations, dentistry, pharmaceutical formulations, etc., to achieve the effect of controllable particle size and uniform size

Pending Publication Date: 2022-06-03
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the high temperature treatment in the sol-hydrothermal method can cause agglomeration defects to be solved

Method used

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  • Antibacterial dentin adhesive and preparation method thereof
  • Antibacterial dentin adhesive and preparation method thereof
  • Antibacterial dentin adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) Preparation of solution A: add 5 mL of tetrabutyl titanate and 5 mL of absolute ethanol into the dropper respectively;

[0056] (2) Preparation of solution B: 20 ​​mL of absolute ethanol, 5 mL of deionized water, 1 mL of concentrated nitric acid, 0.0130 mL of ammonia water, 0.1224 mL of zinc nitrate hexahydrate [Zn(NO 3 ) 2 6(H 2 O)] are added in the beaker respectively;

[0057] (3) Add solution A into solution B at a constant rate of 1 drop (0.25ml / min) every 2 seconds, and stir at the same time (rotation speed is 500r / min), and continue to stir after dropping (rotation speed is 500r / min) 2h, a pale yellow transparent sol was obtained;

[0058] (4) The obtained sol was transferred to a hydrothermal kettle, heated at 160° C. for 6h in an electric heating blast drying oven; after the reaction, it was placed in an ultrasonic cleaner and ultrasonically cleaned with absolute ethanol (ultrasonic cleaning power was 150w), and the reaction was carried out at 8000r Cen...

Embodiment 2

[0070] (1) Preparation of solution A: add 5 mL of tetrabutyl titanate and 5 mL of absolute ethanol into the dropper respectively;

[0071] (2) Preparation of solution B: 20 ​​mL of absolute ethanol, 5 mL of deionized water, 1 mL of concentrated nitric acid, 0.014 mL of ammonia water, 0.1311 mL of zinc nitrate hexahydrate [Zn(NO 3 ) 2 6(H 2 O)] are added in the beaker respectively;

[0072] (3) Add solution A into solution B at a constant rate of 1 drop (0.25ml / min) every 2 seconds, and stir at the same time (rotation speed is 500r / min), and continue to stir after dropping (rotation speed is 500r / min) 2h, a pale yellow transparent sol was obtained;

[0073] (4) The obtained sol was transferred to a hydrothermal kettle, heated at 160° C. for 6h in an electric heating blast drying oven; after the reaction, it was placed in an ultrasonic cleaner and ultrasonically cleaned with absolute ethanol (ultrasonic cleaning power was 150w), and the reaction was carried out at 8000r Cent...

Embodiment 3

[0085] (1) Preparation of solution A: add 5 mL of tetrabutyl titanate and 5 mL of absolute ethanol into the dropper respectively;

[0086] (2) Preparation of solution B: 20 ​​mL of absolute ethanol, 5 mL of deionized water, 1 mL of concentrated nitric acid, 0.0149 mL of ammonia water, 0.1398 mL of zinc nitrate hexahydrate [Zn(NO 3 ) 2 6(H 2 O)] are added in the beaker respectively;

[0087] (3) Add solution A into solution B at a constant rate of 1 drop (0.25ml / min) every 2 seconds, and stir at the same time (rotation speed is 500r / min), and continue to stir after dropping (rotation speed is 500r / min) 2h, a pale yellow transparent sol was obtained;

[0088] (4) The obtained sol was transferred to a hydrothermal kettle, heated at 160° C. for 6h in an electric heating blast drying oven; after the reaction, it was placed in an ultrasonic cleaner and ultrasonically cleaned with absolute ethanol (ultrasonic cleaning power was 150w), and the reaction was carried out at 8000r Cen...

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Abstract

The invention discloses an antibacterial dentin adhesive and a preparation method thereof. Relates to the technical field of tooth filling and repairing. Comprising Zn-N-TiO2NPs (Zn-N-TiO2Nanoparticles, Zn-N-TiO2 nanoparticles), the doping concentration of titanium dioxide in the Zn-N-TiO2NPs is as follows: the doping concentration of zinc is 2.8%-3.2%, and the doping concentration of nitrogen is 2.8%-3.2%, and the invention also provides a preparation method. Zinc nitrate hexahydrate and ammonia water are adopted as sources of zinc and nitrogen respectively, titanium dioxide is co-doped through a sol-hydrothermal method, novel Zn and N co-doped titanium dioxide nanoparticles are prepared, under the condition that Zn-N-TiO2NPs is optically excited by a dental LED, the inhibition effect of the nanoparticles on streptococcus mutans is determined, and the application prospect is broad. The invention aims to provide a theoretical basis for the application of Zn-N-TiO2NPs in the field of caries prevention. Meanwhile, the prepared particles are controllable in particle size and uniform in size.

Description

technical field [0001] The invention relates to the technical field of tooth filling and repair, and more particularly relates to an antibacterial dentin adhesive and a preparation method thereof. Background technique [0002] Streptococcus mutans is recognized as the main bacteria causing caries. [0003] At present, nanotechnology has promoted the rapid development of nano-antibacterial materials. Nano-materials have a large specific surface area and can significantly improve the chemical reactivity of the material surface, which opens up a new research angle to inhibit bacteria. Metal and metal oxide nanoparticles have attracted researchers' attention as effective new antibacterial agents. [0004] Titanium dioxide nanoparticles (TiO 2 Nanoparticles, TiO 2 NPs) have good biosafety, low cost, abundant yield, superior chemical properties, and good photocatalytic bactericidal activity. [0005] However, the high temperature treatment in the sol-hydrothermal method can ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/831C01G23/053
CPCA61K6/831C01G23/053C01P2002/72C01P2002/82C01P2002/84C01P2004/03
Inventor 张红闫琳琳张志民赵远航刘新宋嘉卓赵红邹馨颖
Owner JILIN UNIV
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