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Application of sanguinarine in inhibiting growth of multi-drug-resistant serratia marcescens

A Serratia marcescens, multi-drug resistance technology, applied in the field of medicine, to achieve the effect of solving the problem of drug resistance and infection, reducing the fatality rate, and wide application value

Active Publication Date: 2020-03-31
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing literature has not reported that sanguinarine has antibacterial effect on multi-drug resistant Serratia marcescens

Method used

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  • Application of sanguinarine in inhibiting growth of multi-drug-resistant serratia marcescens
  • Application of sanguinarine in inhibiting growth of multi-drug-resistant serratia marcescens
  • Application of sanguinarine in inhibiting growth of multi-drug-resistant serratia marcescens

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Embodiment Construction

[0014] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0015] 1. Drug susceptibility test of Serratia marcescens

[0016] The present invention takes multiple strains of human Serratia marcescens (strain samples are taken from Ningbo Women and Children's Hospital) as starting strains, and selects ampicillin, ampicillin / sulbactam, cefazolin, cefotetan, ceftriaxone, ceftazidime , piperacillin / tazobactam, co-trimoxazole, cefepime, aztreonam, gentamicin, ertapenem, imipenem, tobramycin, amikacin, ciproterone 18 kinds of commonly used antibiotics including floxacin, nitrofurantoin and levofloxacin were tested.

[0017] Pick the pure colonies cultured for 16 hours and dissolve them evenly in 3 mL of sterile saline, and adjust their turbidity to be equal to that of a 0.5 McFarland turbidimetric tube. Antibio...

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Abstract

The invention discloses an application of sanguinarine in inhibiting growth of multi-drug resistant serratia marcescens. According to the invention, sanguinarine has a good in vitro killing effect onmulti-drug resistant serratia marcescens; the sanguinarine can inhibit the growth of the multi-drug-resistant serratia marcescens, the minimum inhibitory concentration is 0.025-0.2 mg / mL, and the minimum bactericidal concentration is 0.05-0.4 mg / mL. The invention provides an inhibition effect of the sanguinarine on the multi-drug-resistant serratia marcescens, and the sanguinarine has wide application value in the fields of medicines and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of sanguinarine in inhibiting the growth of multidrug-resistant Serratia marcescens. Background technique [0002] Serratia marcescens (Serratia marcescens, SM), that is, Serratia marcescens, belongs to the Enterobacteriaceae Serratia genus, is a Gram-negative near-spherical short bacterium, usually found in water, soil, animals and plants Among them, it is an opportunistic pathogenic bacteria that widely exists in nature and in the hospital environment. It can cause lung and urinary tract infections when the body’s immune function is reduced, and it is easy to cause nosocomial epidemic infections. In addition to lung infections and urinary tract infections, it also includes meningeal infections. Inflammation, endocarditis, post-burn sepsis, etc. [0003] Serratia marcescens causes nosocomial infections and outbreaks in severely immunocompromised or critically ill patient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04Y02A50/30
Inventor 钱卫东付玉婷刘淼刘婉婷张家宁孙照欢杨敏李靖原
Owner SHAANXI UNIV OF SCI & TECH
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