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Use of Asterias rollestoni Bell extract in preparation of antitumor drug

An anti-tumor drug, the technology of Roche's sea wheel, which is applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve the problem of lack of effective drugs for liver cancer, and achieve the effect of obvious inhibition and clear inhibition.

Active Publication Date: 2014-06-25
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still no effective drug for the treatment of liver cancer

Method used

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  • Use of Asterias rollestoni Bell extract in preparation of antitumor drug
  • Use of Asterias rollestoni Bell extract in preparation of antitumor drug
  • Use of Asterias rollestoni Bell extract in preparation of antitumor drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take Asterias rollestoni with a dry weight of 1 kg, soak and extract with 2 liters of 95% ethanol at room temperature for 3 times, each time for 24 hours, combine the extracts and concentrate to obtain the extract, which is the ethanol extract, suspend the extract in water, and first Add 1 liter of ethyl acetate to extract 3 times, then add 1 liter of n-butanol to extract 3 times, and concentrate to obtain 20 grams of ethyl acetate extract (i.e. ethyl acetate extract) and n-butanol extract (i.e. n-butanol extract). matter) 18 grams. Example 2

Embodiment 2

[0028] Take Asterias rollestoni with a dry weight of 1 kg, soak and extract with 2 liters of 70% ethanol at room temperature for 3 times, each time for 24 hours, combine the extracts and concentrate to obtain the extract, which is the ethanol extract, suspend the extract in water, and first Add 1 liter of ethyl acetate to extract 3 times and then add 1 liter of n-butanol to extract 3 times. After concentration, 22 grams of ethyl acetate extract (i.e. ethyl acetate extract) and n-butanol extract (i.e. n-butanol extract) are obtained respectively. matter) 19 grams. Example 3

Embodiment 3

[0029] Take Asterias rollestoni with a dry weight of 1 kg, heat and reflux extraction with 2 liters of 95% ethanol for 3 times for 1 hour, combine the extracts and concentrate to obtain the extract, which is the ethanol extract, suspend the extract with water, and add 1 Extract with 1 liter of ethyl acetate for 3 times, then add 1 liter of n-butanol for extraction for 3 times, and concentrate to obtain 28 grams of ethyl acetate extract (i.e. ethyl acetate extract) and n-butanol extract (i.e. n-butanol extract) 24 grams.

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Abstract

The invention relates to the field of preparation of antitumor drugs and especially relates to a use of Asterias rollestoni Bell extract in preparation of an antitumor drug. The Asterias rollestoni Bell extract is Asterias rollestoni Bell alcohol extract extracted from Asterias rollestoni Bell by a solvent. The solvent is a methanol aqueous solution or an ethanol aqueous solution or a mixed solution of methanol and ethanol. The Asterias rollestoni Bell extract also can be ethyl acetate extract or n-butanol extract of the Asterias rollestoni Bell alcohol extract. An experiment proves that the Asterias rollestoni Bell extract has moderate antitumor activity, and can obviously inhibit mice H22 solid tumor and mice S180 solid tumor, and especially, the ethyl acetate extract of the Asterias rollestoni Bell alcohol extract has obvious inhibition effects. Therefore, the Asterias rollestoni Bell extract can be used for treating cancers and especially for liver cancer.

Description

technical field [0001] The present invention relates to the field of preparation of antineoplastic drugs, in particular to the application of Roche's spriga extract in the preparation of antineoplastic drugs. Background technique [0002] Asterias rollestoni Bell (Asterias rollestoni Bell) has a five-pointed star-shaped body, very flat, with a slightly wider disc, 5 arms, about 12cm in radial diameter, and about 3cm in interradial diameter. The base of the carpus is slightly reduced, the end is tapered and raised, and the edge is very sharp. The back plate is combined into an irregular network with many nodules, the back spines are short and sparse, and the spines on the keel are arranged more regularly and neatly. The dorsal spines are conical, or broad and blunt, with a truncation at the top, but not longitudinal grooves. The upper limbal plate forms the edge of the wrist, and each plate generally has about 3 upper marginal spines, and the lower marginal plate is on the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J31/00A61K35/56A61P35/00A61P1/16A61K31/575A61K35/616
Inventor 刘永宏周雪峰林秀萍杨斌王隶书杨献文
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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