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Application of chelerythrine in inhibiting growth of multi-drug resistant providencia rettgeri

A technology of Providencia reytii and Providencia is applied in pharmaceutical formulations, antibacterial drugs, medical preparations containing active ingredients, etc. It can solve problems such as bacterial differences, reduce fatality rate, solve Effects of drug resistance and infection problems

Active Publication Date: 2020-04-14
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Providencia rettgeri and Escherichia coli do not belong to the same genus, and there are significant differences between the two bacteria
At present, there is no literature report that chelerythrine has antibacterial effect on multi-drug resistant Providencia rettii

Method used

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  • Application of chelerythrine in inhibiting growth of multi-drug resistant providencia rettgeri
  • Application of chelerythrine in inhibiting growth of multi-drug resistant providencia rettgeri
  • Application of chelerythrine in inhibiting growth of multi-drug resistant providencia rettgeri

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Embodiment Construction

[0013] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0014] 1. Drug susceptibility test of Providencia rettgeri

[0015] The present invention takes 5 strains of Providencia rettgeri (strain samples taken from Ningbo Women and Children's Hospital) as starting strains, and selects ampicillin, ampicillin / sulbactam, cefazolin, cefotetan, ceftriaxone , ceftazidime, piperacillin / tazobactam, co-trimoxazole, cefepime, aztreonam, gentamicin, ertapenem, imipenem, tobramycin, amikacin, Eighteen commonly used antibiotics including ciprofloxacin, nitrofurantoin and levofloxacin were tested.

[0016] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. The antibiotics, bacter...

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Abstract

The invention discloses application of chelerythrine in inhibiting the growth of multi-drug resistant providencia rettgeri. Chelerythrine has a good in-vitro killing effect, can inhibit the growth ofmulti-drug resistant providencia rettgeri, also a minimum bactericidal concentration is 20-250microg / mL, and a minimal inhibitory concentration is 10-125microg / mL. The invention puts forward the inhibition effect of chelerythrine on the multi-drug resistant providencia rettgeri, and has wide application value in medicine and other fields.

Description

technical field [0001] The invention relates to the fields of medicine and food safety, in particular to the application of chelerythrine in inhibiting the growth of multidrug-resistant Providencia rettgeri. Background technique [0002] Providencia rettgeri (Providencia rettgeri) is a Gram-negative rod-shaped Enterobacteriaceae bacterium that can cause diarrhea, extraintestinal infection and urinary tract infection, and may cause acute gastroenteritis in severe cases. It is easy to be contaminated by the bacteria during food processing, transportation and sales, leading to food poisoning. In recent years, artificially synthesized antibiotics have been widely used in the clinical treatment of bacterial infections. However, due to the excessive use of antibiotics, bacteria are increasingly resistant to antibiotics, leading to the emergence of superbugs. [0003] Due to the novel structure, high curative effect and less adverse reactions of the active substances provided by t...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04Y02A50/30
Inventor 钱卫东李靖原刘淼付玉婷刘婉婷张家宁杨敏孙照欢
Owner SHAANXI UNIV OF SCI & TECH
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