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Application of luteolin in inhibition of growth of multi-drug-resistant providencia rettgeri

A technology of Providencia rettgeri and Providencia bacteria, applied in the direction of antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Active Publication Date: 2020-03-31
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no literature report that luteolin has antibacterial effect on multi-drug resistant Providencia rettii

Method used

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  • Application of luteolin in inhibition of growth of multi-drug-resistant providencia rettgeri
  • Application of luteolin in inhibition of growth of multi-drug-resistant providencia rettgeri
  • Application of luteolin in inhibition of growth of multi-drug-resistant providencia rettgeri

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Embodiment Construction

[0013] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0014] 1. Drug susceptibility test of Providencia rettgeri

[0015] The present invention takes multiple strains of Providencia rettgeri (strain samples taken from Ningbo Women and Children's Hospital) as starting strains, and selects ampicillin, ampicillin / sulbactam, cefazolin, cefotetan, ceftriaxone , ceftazidime, piperacillin / tazobactam, co-trimoxazole, cefepime, aztreonam, gentamicin, ertapenem, imipenem, tobramycin, amikacin, 18 commonly used antibiotics such as ciprofloxacin, nitrofurantoin and levofloxacin were tested.

[0016] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. The antibiotics, bacteri...

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Abstract

The invention discloses application of luteolin in inhibition of growth of multi-drug-resistant providencia rettgeri. According to the invention, because the luteolin has a good in-vitro killing effect on multi-drug-resistant providencia rettgeri, the growth of the multi-drug-resistant providencia rettgeri can be inhibited; and the minimum bactericidal concentration is 30 to 250 microgram / mL and the minimum bacteriostatic concentration is 15 to 125 microgram / mL. The luteolin has an inhibiting effect on the multi-drug-resistant providencia rettgeri and thus has the great application value in the fields of medicines and the like.

Description

technical field [0001] The invention relates to the fields of medicine and food safety, in particular to the application of luteolin in inhibiting the growth of multidrug-resistant Providencia rettgeri. Background technique [0002] Providencia rettgeri (Providencia rettgeri) belongs to the Enterobacteriaceae family, is associated with multiple diseases, can cause urinary tract infections and other extraintestinal infections, and has caused outbreaks of many nosocomial infections (Tshisevhe V S, Lekalakala M R, Tshuma N , et al.Outbreak of carbapenem-resistant Providenciarettgeri in a tertiary hospital[J].S Afr Med J,2017,107(1):31-33; O"Hara C M,Brenner F W,Miller J M.Classification,Identification, and ClinicalSignificance of Proteus, Providencia, and Morganella[J].Clinical MicrobiologyReviews,2000,13(4):534-546.).Providencia rettgeri is resistant to many antibacterial drugs, including ampicillin, first-generation cephalosporins Multimyxin, polymyxin and oxytetracycline (M...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P31/04
CPCA61K31/352A61P31/04
Inventor 钱卫东刘婉婷刘淼付玉婷张家宁杨敏孙照欢李靖原
Owner SHAANXI UNIV OF SCI & TECH
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