A kind of herpetetrone nano-suspension and its dry powder, preparation method and application
A nano-suspension and dry powder technology, which is applied in powder delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of low solubility, slow dissolution rate limitation, and influence on drug efficacy, etc. Enhanced inhibitory effect, enhanced oral bioavailability
Active Publication Date: 2022-06-03
AIR FORCE MEDICAL CENT PLA
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Problems solved by technology
However, Herpetetrone is a poorly soluble drug. Due to its low solubility and slow dissolution rate, the absorption of the drug is limited, which in turn affects its efficacy.
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Abstract
The invention discloses a Herpetetrone nano-suspension and its dry powder, preparation method and application, and belongs to the technical field of traditional Chinese medicine oral medicine. The Herpetetrone nanosuspension is prepared by ultrasonic precipitation. The preparation method of the suspension dry powder comprises: preparation of Herpetetrone nano-suspension; preparation of Herpetetrone nano-suspension dry powder. The Herpetetrone nanosuspension or the Herpetetrone nanosuspension dry powder dissolves more than 90% within 2 hours; it has a significant inhibitory effect on the proliferation of HSC-T6 liver fibroblasts. The application is in the preparation of medicines for treating liver diseases. The invention has the following advantages: the dissolution rate in vitro is obviously improved, the oral bioavailability in vivo is obviously improved, and the inhibitory effect on HSC-T6 cells is enhanced simultaneously.
Description
A kind of Herpetetrone nano suspension and its dry powder, preparation method and application technical field The invention belongs to traditional Chinese medicine oral medicine technical field, relate to a kind of Herpetetrone nano suspension and dry thereof Powder, preparation method and application; specifically relate to the preparation and physicochemical of Herpetetrone nanosuspension for treating liver disease Characterization; inhibition of liver fibroblasts and investigation of oral bioavailability. Background technique Liver fibrosis is the wound healing response of the liver to liver injury caused by various reasons, and is common to various chronic liver diseases. pathological process. The occurrence of liver fibrosis is caused by the imbalance between the synthesis and degradation of extracellular matrix (ECM), and the excessive deposition of ECM is a pathological condition. feature. ECM is mainly derived from hepatic stellate cells (HSCs), and is acti...
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IPC IPC(8): A61K9/10A61K9/14A61K31/34A61K36/42A61K47/32A61P1/16A61K131/00
CPCA61K9/10A61K9/146A61K31/34A61K47/32A61K36/42A61P1/16Y02A50/30
Inventor 袁海龙申宝德钟雨佶沈成英刘肖
Owner AIR FORCE MEDICAL CENT PLA
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