Application of sanguinarine to restraining growth of staphylococcus lugdunensis

A technology of Staphylococcus ludunensis and Staphylococcus ludunensis, applied in the application field of sanguinarine in inhibiting the growth of Staphylococcus ludunensis, can solve problems such as differences, reduce fatality rate, solve drug resistance and infection problems, and be widely used value effect

Pending Publication Date: 2020-02-11
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Sanguinarine (C 20 h 14 NO 4 ) is a benphenanthridine isoquinoline alkaloid isolated from Papaveraceae plants such as Celandine, Boluohui, etc. It has various pharmacological activities, such as insecticidal, anti-tumor, antibacterial, anti-inflammatory, and improving liver function , Immunity enhancement, etc. It has been reported that

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  • Application of sanguinarine to restraining growth of staphylococcus lugdunensis
  • Application of sanguinarine to restraining growth of staphylococcus lugdunensis
  • Application of sanguinarine to restraining growth of staphylococcus lugdunensis

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Embodiment Construction

[0014] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0015] 1. Drug susceptibility test of human-sourced Staphylococcus ludunensis

[0016] The present invention uses multiple strains of human-derived Staphylococcus ludunensis (strain samples taken from the Ningbo Center for Disease Control and Prevention) as starting strains, and selects penicillin, clindamycin, tetracycline, ciprofloxacin, vancomycin, and oxacillin6 Antimicrobial susceptibility tests were carried out on the susceptibility test strips of commonly used antibiotics.

[0017] The pure colonies picked and cultured for 18-24 hours were uniformly dissolved in 2-5 mL of sterile TSB liquid medium, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. Pipette 50-200 μL of bacterial solution in a sterile en...

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Abstract

The invention discloses an application of sanguinarine to restraining growth of staphylococcus lugdunensis. The sanguinarine has better in vitro destroying effects on medicine-resistant staphylococcuslugdunensis and can restrain the growth of the medicine-resistant staphylococcus lugdunensis, the minimum bactericidal concentration is 30 [mu]g/mL, and the minimal inhibitory concentration is 15[mu]g/mL. The invention provides the restraining effects of the sanguinarine on the staphylococcus lugdunensis, and the sanguinarine has high application value in the field of pharmaceuticals and the like.

Description

technical field [0001] The invention relates to the research, development and application of sanguinarine, an active ingredient of traditional Chinese medicine, as an inhibitor of Staphylococcus ludunensis, in particular to the application of sanguinarine in inhibiting the growth of Staphylococcus ludunensis. Background technique [0002] Staphylococcus lugdunensis, one of the more virulent coagulase-negative staphylococci, has become an important human pathogen that can cause a series of infectious diseases, such as endocarditis, lymphadenitis , ophthalmia, bone and joint infection, but more commonly skin and soft tissue infection, the infectious disease caused by it is serious and develops rapidly, with many complications and high mortality. For the treatment of infectious diseases caused by Staphylococcus ludunensis, according to previous studies, it has developed resistance to penicillin, and its sensitivity to azithromycin, chloramphenicol and gentamicin has gradually d...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04
Inventor 钱卫东杨敏李鑫辰孙照欢刘淼张家宁付玉婷王文静
Owner SHAANXI UNIV OF SCI & TECH
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