Application of chelerythrine in inhibiting growth of streptococcus pneumonia

A technology of Streptococcus pneumoniae and chelerythrine, applied in the direction of antibacterial drugs, medical preparations containing active ingredients, organic active ingredients, etc., to reduce mortality, solve drug resistance and infection problems, and have wide application value Effect

Pending Publication Date: 2020-05-29
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report on chelerythrine inhibiting the growth of highly pathogenic Streptococcus pneumoniae

Method used

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  • Application of chelerythrine in inhibiting growth of streptococcus pneumonia
  • Application of chelerythrine in inhibiting growth of streptococcus pneumonia
  • Application of chelerythrine in inhibiting growth of streptococcus pneumonia

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Embodiment Construction

[0014] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0015] 1. Drug susceptibility test of Streptococcus pneumoniae

[0016] The present invention uses multiple strains of human Streptococcus pneumoniae (strain samples taken from Beijing Haidian Hospital) as starting strains, and selects levofloxacin, ofloxacin, moxifloxacin, erythromycin, chloramphenicol, and telithromycin 10 commonly used antibiotics were tested, including tricycline, vancomycin, linezolid, and co-trimoxazole.

[0017] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. The antibiotics, bacterial liquid and TSB liquid medium were added to the 96-well culture plate by the double dilution method ...

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Abstract

The invention discloses an application of chelerythrine in inhibiting the growth of streptococcus pneumonia. According to the fact that the chelerythrine has good in-vitro bactericidal effect on the streptococcus pneumonia, the chelerythrine can inhibit the growth of the streptococcus pneumonia, and has a minimum bactericidal concentration of 31.2 [mu]g / mL and a minimum bacteriostatic concentration of 15.6 [mu]g / mL. The invention provides the inhibition effect of the chelerythrine on the streptococcus pneumonia; and the chelerythrine has wide application value in the fields of medicines and the like.

Description

technical field [0001] The invention relates to the fields of medicine and food safety, in particular to the application of chelerythrine in inhibiting the growth of Streptococcus pneumoniae. Background technique [0002] Streptococcus pneumoniae (Streptococcus pneumoniae) is a gram-positive bacterium of the genus Streptococcus in the family Streptococcus, which can cause a variety of infections. Gram staining can be negative when the bacteria are senescent, or after the bacteria are lysed due to the production of autolytic enzymes. Streptococcus pneumoniae can also invade other parts of the body, causing middle ear effusion, chronic otitis media, temporary deafness or slow speech, etc. In severe cases, complications such as meningitis, endocarditis, and shock may even occur. The pathogenic substances are capsule, pneumolysin O, lipoteichoic acid and neuraminidase. 75% of adult Streptococcus pneumoniae pneumonia and more than 50% of severe Streptococcus pneumoniae bacterem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4741A61P31/04
CPCA61K31/4741A61P31/04
Inventor 钱卫东崔雅欣刘淼付玉婷张家宁杨敏孙照欢
Owner SHAANXI UNIV OF SCI & TECH
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