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Bacteriostatic and antiviral preparation taking kidney bean phytohemagglutinin as major ingredient

A plant lectin and antiviral technology, applied in the field of medicine, can solve problems such as long storage time, achieve the effects of long storage time, improve humoral immunity level, and restore self-purification effect

Active Publication Date: 2018-08-17
YUNNAN KANGZHOU BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The Chinese patent document with the application number 2013100565888 discloses a kind of "Application of Kidney Bean Phytohemagglutinin in the Preparation of Human Drugs and its Pharmaceutical Composition". sugar, bletilla jelly, or adding scutellaria baicalensis, three needles, and flavescens extracts as active components, the product does not need to be stored at low temperature, has a long storage time, and is easy to use, but its antibacterial, antiviral ability and quality stability are still relatively low. needs to be further improved

Method used

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  • Bacteriostatic and antiviral preparation taking kidney bean phytohemagglutinin as major ingredient
  • Bacteriostatic and antiviral preparation taking kidney bean phytohemagglutinin as major ingredient
  • Bacteriostatic and antiviral preparation taking kidney bean phytohemagglutinin as major ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0125] Example 1: Formulation A. In 100ml of liquid gel contains:

[0126] 0.4-0.5 grams of white kidney bean lectin,

[0127] Oligosaccharides (total amount of stachyose and raffinose) 0.5g,

[0128] Chemical antibacterial agent: 0.2-0.5 grams of povidone-iodine,

[0129] Chemical antibacterial agent: 0.1-0.3 grams of polyhexamethyleneguanidine,

[0130] Chemical antibacterial agent: 0.1-0.3 grams of chlorhexidine acetate,

[0131] NaCl 0.85 g,

[0132] pH buffer: acetic acid-sodium acetate buffer solution (pH4.5, get 1.8 grams of sodium acetate, add glacial acetic acid 0.98ml,

[0133] Add water to dilute to 100ml, that is,

[0134] Stabilizer: 0.5-2.0 grams of PEG 4000,

[0135] Thickener hydroxyethyl cellulose 1.4-2.0 grams,

[0136] The pH value is 4.3-4.8.

Embodiment 2

[0137] Example 2: Formulation B. In 100ml of liquid gel contains:

[0138] 0.4-0.5 grams of red kidney bean lectin,

[0139] Oligosaccharides (total amount of stachyose and raffinose) 0.2-0.5g,

[0140] Chemical antibacterial agent: 0.2-0.5 grams of povidone-iodine,

[0141] Chemical antibacterial agent: 0.1-0.3 grams of polyhexamethyleneguanidine,

[0142] 0.7-0.85 grams of NaCl,

[0143] pH buffer: acetic acid-sodium acetate buffer solution (pH4.5, take 1.8 grams of sodium acetate, add 0.98 ml of glacial acetic acid, and then dilute to 100 ml with water, to obtain,

[0144] Stabilizer: 0.5-2.0 grams of PEG 4000,

[0145] Thickener hydroxyethyl cellulose 1.2 ~ 2.0 grams

[0146] pH value is 4.3~4.8

Embodiment 3

[0147] Embodiment 3: Subtract the thickener on the basis of formulas A and B to obtain a chemical antibacterial (washing) solution for kidney bean lectin.

[0148] 0.4-0.5 grams of plant lectins,

[0149] 0.3-0.5 grams of oligosaccharides,

[0150] Chemical antibacterial agent: 0.2-0.5 grams of povidone-iodine,

[0151] Chemical antibacterial agent: 0.1-0.3 grams of polyhexamethyleneguanidine.

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Abstract

The invention discloses a bacteriostatic and antiviral preparation taking kidney bean phytohemagglutinin as a major ingredient, and belongs to the technical field of medicines. The bacteriostatic andantiviral preparation consists of the following active components according to relative parts by weight: 0.1-1.0 part of the kidney bean phytohemagglutinin, 0.2-2.0 parts of one or two of stachyose and raffinose as well as one or more of the following active components: 0.1-0.5 part of povidone iodine, 0.1-0.3 part of polyhexylene biguanidine and 0.1-0.5 part of chlorhexidine; and in addition, a thickening agent, which is hydroxyethyl cellulose, is required. The bacteriostatic and antiviral preparation provided by the invention is concrete in components, and is capable of achieving quantitative control and guaranteeing the consistency and stability of overall quality; a concrete inhibitory effect can be achieved on bacteria, fungi and viruses; therefore, the bacteriostatic and antiviral preparation is relatively broad in antibacterial and antiviral ranges; and the product (the bacteriostatic and antiviral preparation), which is required to be preserved at low temperature, is long in preservation duration and convenient to use.

Description

technical field [0001] The invention belongs to the technical field of medicines. Background technique [0002] At present, sexually transmitted diseases (STDs), including HIV, pose a great threat to people's physical and mental health, and the abuse of antibiotics has also led to the widespread emergence of drug-resistant bacteria. For viral diseases, the problem people face is that there are many types of viruses, and some viruses mutate quickly. For example, due to the rapid mutation of HIV virus, there has been no ideal effective vaccine against HIV for many years. There is an urgent need to have broad-spectrum antibacterial and antiviral, use simple formulations for daily protection and treatment. Burns, frostbite, knife wounds, abrasions, contusions and other general trauma, disinfection with iodophor is very effective. Compared with iodine and alcohol, povidone iodine causes mild irritation and pain, is easy to be accepted by patients, and has a wide range of uses a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K9/08A61K9/06A61P15/02A61P31/02A61P31/04A61P31/10A61P37/04A61K31/155A61K31/702A61K31/785A61K31/79
CPCA61K9/0034A61K9/06A61K9/08A61K31/155A61K31/702A61K31/785A61K31/79A61K38/168A61K47/38A61P15/02A61P31/02A61P31/04A61P31/10A61P37/04A61K2300/00
Inventor 王敏康赵红
Owner YUNNAN KANGZHOU BIOLOGICAL SCI & TECH
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