Application of luteolin in inhibiting the growth of multi-drug-resistant Providencia reinhardtii

A technology of Providencia rettgeri and Providencia bacteria, applied in the direction of pharmaceutical formulations, antibacterial drugs, medical preparations containing active ingredients, etc., to solve the problem of drug resistance and infection, reduce the fatality rate, and widely The effect of applying value

Active Publication Date: 2021-08-13
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report that luteolin has antibacterial effect on multi-drug resistant Providencia rettii

Method used

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  • Application of luteolin in inhibiting the growth of multi-drug-resistant Providencia reinhardtii
  • Application of luteolin in inhibiting the growth of multi-drug-resistant Providencia reinhardtii
  • Application of luteolin in inhibiting the growth of multi-drug-resistant Providencia reinhardtii

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Embodiment Construction

[0013] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0014] 1. Drug susceptibility test of Providencia rettgeri

[0015] The present invention takes multiple strains of Providencia rettgeri (strain samples taken from Ningbo Women and Children's Hospital) as starting strains, and selects ampicillin, ampicillin / sulbactam, cefazolin, cefotetan, ceftriaxone , ceftazidime, piperacillin / tazobactam, co-trimoxazole, cefepime, aztreonam, gentamicin, ertapenem, imipenem, tobramycin, amikacin, 18 commonly used antibiotics such as ciprofloxacin, nitrofurantoin and levofloxacin were tested.

[0016] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. The antibiotics, bacteri...

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Abstract

The invention discloses the application of luteolin in inhibiting the growth of multi-drug-resistant Providencia rettgeri. According to the fact that luteolin has a good in vitro killing effect on multi-drug-resistant Providencia rettgeri, it can inhibit multiple The growth of drug-resistant Providencia rettgeri, and the minimum bactericidal concentration is 30 ~ 250 μg / mL, the minimum inhibitory concentration is 15 ~ 125 μg / mL, the present invention proposes that luteolin is effective against multidrug-resistant Providencia rettgeri The inhibitory effect of S. spp. has wide application value in medicine and other fields.

Description

technical field [0001] The invention relates to the fields of medicine and food safety, in particular to the application of luteolin in inhibiting the growth of multidrug-resistant Providencia rettgeri. Background technique [0002] Providencia rettgeri (Providencia rettgeri) belongs to the Enterobacteriaceae family, is associated with multiple diseases, can cause urinary tract infections and other extraintestinal infections, and has caused outbreaks of many nosocomial infections (Tshisevhe V S, Lekalakala M R, Tshuma N , et al.Outbreak of carbapenem-resistant Providenciarettgeri in a tertiary hospital[J].S Afr Med J,2017,107(1):31-33; O' Hara C M,Brenner F W,Miller J M. Classification, Identification, and Clinical Significance of Proteus, Providencia, and Morganella [J]. Clinical Microbiology Reviews, 2000, 13(4):534-546.). Providencia rettgeri is resistant to many antibacterial drugs, including ampicillin, first-generation cephalosporins, polymyxins, and oxytetracycline (...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P31/04
CPCA61K31/352A61P31/04
Inventor 钱卫东刘婉婷刘淼付玉婷张家宁杨敏孙照欢李靖原
Owner SHAANXI UNIV OF SCI & TECH
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