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Application of polyphyllins in preparation of preparation for treating acnes

A technology of saponins and acnes, which is applied in the direction of medical preparations containing active ingredients, antibacterial drugs, organic active ingredients, etc., can solve the problems of irritation safety, drug resistance, and affect the treatment effect of acne, and achieve the goal of reducing resistance. Drug and irritation, safety improvement effect

Inactive Publication Date: 2017-11-24
FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV +1
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Problems solved by technology

The external therapeutic drugs against Propionibacterium acnes mainly include antibiotics, benzoyl peroxide, etc. Although they can achieve the purpose of treatment, there are also problems such as drug resistance, irritation and safety, which seriously affect the therapeutic effect of acne

Method used

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  • Application of polyphyllins in preparation of preparation for treating acnes
  • Application of polyphyllins in preparation of preparation for treating acnes

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Embodiment Construction

[0007] EXAMPLES Samples were prepared by the inventor, and the test method was a conventional liquid microdilution method.

[0008] Total saponins and components of papaya saponins: Ⅰ (CAS No.: 50773-41-6 Molecular Formula: C44H70O16 Molecular Weight: 855.02), Ⅱ (CAS No.: 76296-72-5 Molecular Formula: C44H70O16 Molecular Weight: 855.017), Ⅲ (CAS No. : 19057-60-4 Molecular Formula: C45H72O16 Molecular Weight: 869.05), Ⅴ (CAS No.: 19057-67-1 Molecular Formula: C39H62O12 Molecular Weight: 722), Ⅵ (CAS No.: 55916-51-3 Molecular Formula: C39H62O13 Molecular Weight: 738.90), VII (CAS number: 76296-75-8 molecular formula: C51H84O22 molecular weight: 1049.22), H (CAS number: 81917-50-2 molecular formula: C44H70O17 molecular weight: 870). The above-mentioned saponins Ⅰ, Ⅱ, Ⅵ, and Ⅶ were purchased from Nanjing Puyi Biotechnology Co., Ltd. Before the experiment, 10 mg of the sample to be tested was dissolved in 0.1 ml of DMSO as a stock solution, and the aliquots were diluted to a final...

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Abstract

The invention relates to the application of papaya saponin in the preparation of preparations for treating acne, and belongs to the technical field of biomedicine. The present invention uses the self-made saponins of papaya, and observes in vitro experiments with liquid micro-dilution method, and the experiment proves that total saponins of papaya and saponins Ⅰ, Ⅱ, Ⅵ, and Ⅶ are effective against Propionibacterium acnes, Staphylococcus epidermidis and aureus in vitro. Staphylococcus has definite inhibitory effect and is used in the preparation of acne treatment preparations. The beneficial effects of the present invention are: the addition of plant-extracted papaya saponins to acne preparations not only has a definite inhibitory effect on Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus, but also reduces the drug resistance and Irritation, providing safety of the preparation.

Description

technical field [0001] The invention relates to the application of papaya saponin in the preparation of preparations for treating acne, and belongs to the technical field of biomedicine. Background technique [0002] Acne is a skin disease with an incidence rate as high as 46.8% among young people. It has become one of the important diseases affecting the healthy growth of young people because it not only affects the physical health of the patients, but also affects the mental health due to the damaged appearance. Current studies have shown that the main pathogenic bacteria of acne are Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus. The topical therapeutic drugs against Propionibacterium acnes mainly include antibiotics and benzoyl peroxide. Although they can achieve the purpose of treatment, they also have problems such as drug resistance, irritation and safety, which seriously affect the therapeutic effect of acne. Excavating natural active ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P17/10A61P31/04
CPCA61K31/7048
Inventor 何黎孙东杰吴文娟刘海洋涂颖郭振宇马骁
Owner FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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