Application of pulsatilla saponin A3 in inhibiting growth of multi-drug-resistant Providencia rettgeri

A technology of Providencia rettgeri and Providencia bacteria, applied in the direction of antibacterial drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve the effect of wide application value

Active Publication Date: 2020-06-05
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology can help prevent Multi Drug Resistance (MDR) caused by certain compounds from causing harm or even death for people who are already taking multiple drugs simultanously.

Problems solved by technology

The technical problem addressed in this patents relates to finding novel ways to prevent and treat microorganisms like those found naturally occurring within humans through use of probes called Microbactors® derived from Palexporidae Root Body Fungi. These agents include several types including butterburazoxane, nigerospondezvousness virus-, cytotaxel-, shuttlefish lyssinochlorophyll-17B) and certain metabolites produced by these generators.

Method used

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  • Application of pulsatilla saponin A3 in inhibiting growth of multi-drug-resistant Providencia rettgeri
  • Application of pulsatilla saponin A3 in inhibiting growth of multi-drug-resistant Providencia rettgeri
  • Application of pulsatilla saponin A3 in inhibiting growth of multi-drug-resistant Providencia rettgeri

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Embodiment Construction

[0021] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the content of the present invention, not to limit the present invention.

[0022] Pulsatilla saponin A3, the English name is Anemoside A3 Pulchinenoside A3, the molecular formula is C 41 h 66 o 12 , relative molecular mass is 750.95554, density: 1.31, solubility: soluble in methanol, acetonitrile, ethanol and other solvents, insoluble in petroleum ether. Appearance: white crystalline powder. The source of extraction is Pulsatilla pulsatillae, a plant of Ranunculaceae. The CAS number is 129724-84-1, the CB number is CB42491699, and the molecular structure is as follows:

[0023]

[0024] 1. Drug susceptibility test of Providencia rettgeri

[0025] The present invention takes 5 strains of Providencia rettgeri from Ningbo Women and Children's Hospital as starting strains, and selects ampicillin, ampicillin / sulbactam, cefazolin, c...

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Abstract

The invention discloses an application of pulsatilla saponin A3 in inhibiting the growth of multi-drug-resistant Providencia rettgeri. According to the invention, the pulsatilla saponin A3 has good in-vitro killing effect on human-derived Providencia rettgeriis with resistance to ampicillin, ampicillin/sulbactam, cefazolin, cefotetan, ceftriaxone, ceftazidime, tobramycin, piperacillin tazobactam,ciprofloxacin, levofloxacin, amikacin, compound phenoxymine, cefepime, ertapenem, imipenem, aztreonam and gentamicin, can inhibit in-vitro growth of the multi-drug-resistant Providencia rettgeri, andhas a minimum inhibitory concentration of 125 [mu]g/mL and a minimum bactericidal concentration of 250 [mu]g/mL. The pulsatilla saponin A3 provided by the ivnention has an antibacterial effect on themulti-drug-resistant Providencia rettgeri, can relieve or solve the problem that the drug resistance of the multi-drug-resistant Providencia rettgeri is increased, and provides a theoretical basis forclinical antibacterial treatment and novel drug research and development.

Description

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Claims

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Application Information

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Owner SHAANXI UNIV OF SCI & TECH
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