Application of citral in inhibition of growth of multi-drug resistant providencia rettgeri

A technology of Providencia reaetii and Providencia spp. is applied in the direction of antibacterial drugs, active ingredients of aldehydes, etc., which can solve the problems such as the unreported bacteriostatic effect of citral, and solve the problem of drug-resistant infection, The effect of reducing the fatality rate and wide application value

Inactive Publication Date: 2020-02-21
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, the existing literature has not reported that citral ha

Method used

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  • Application of citral in inhibition of growth of multi-drug resistant providencia rettgeri
  • Application of citral in inhibition of growth of multi-drug resistant providencia rettgeri
  • Application of citral in inhibition of growth of multi-drug resistant providencia rettgeri

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[0020] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the content of the present invention, not to limit the present invention.

[0021] Citral, English name Citral, molecular formula C 10 h 16 O, with a relative molecular weight of 152.23, is a colorless or slightly yellow liquid with a strong lemon scent. Exist in citrus oil, lemon oil, lemongrass oil, litsea cubeba oil, lime oil, verbena oil and other plant essential oils. The CAS number is 5392-40-5, the boiling point is 228-229°C, and the molecular structure is:

[0022]

[0023] 1. Drug susceptibility test of Providencia rettgeri

[0024] The present invention takes 5 strains of Providencia rettgeri as starting strains, selects ampicillin, ampicillin / sulbactam, cefazolin, cefotetan, ceftriaxone, ceftazidime, tobramycin, piperacillin Zobactam, ciprofloxacin, levofloxacin, amikacin, cotrimoxazole, cefepime, ertapenem, imipenem,...

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Abstract

The invention discloses application of citral in inhibition of growth of multi-drug resistant providencia rettgeri. The citral has better in-vitro killing effects on human-derived providencia rettgeriresisting ampicillin, ampicillin/sulbactam, cefazolin, cefotetan, ceftriaxone, ceftazidime, tobramycin, tazobactam and piperacillin, ciprofloxacin, levofloxacin, amikacin, cotrimoxazole, cefepime, ertapenem, imipenem, aztreonam and gentamicin, can inhibit growth of resistant providencia rettgeri, and has the minimum bactericidal concentration of 0.5 mg/mL and the minimum inhibitory concentrationof 0.25 mg/mL; and the inhibition function of the plant extract citral on the multi-drug resistant providencia rettgeri can relieve or solve the problem of increase of drug resistance of the multi-drug resistant providencia rettgeri and provide a theoretical basis for clinical antibacterial treatment and research and development of novel drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine and food safety, and relates to the application of citral in inhibiting the growth of multidrug-resistant Providencia rettgeri. Background technique [0002] Providencia rettgeri belongs to Enterobacteriaceae, which can cause urinary tract infection and other extraintestinal infections, and cause outbreaks of many nosocomial infections. Infection and food poisoning can be caused by massive multiplication in the process. In addition, there are reports of traveler's diarrhea, eye infection, bacteremia, and urinary tract infection caused by this bacteria at home and abroad. In recent years, the clinical isolation rate of multidrug-resistant Providencia rettgeri has gradually increased. There have been many foreign literature reports that Providencia rettgeri can produce IMP-1 metallo-β-lactamases and various A β-lactamase. Another domestic document reported that the clinically isolated Providenci...

Claims

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Application Information

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IPC IPC(8): A61K31/11A61P31/04
CPCA61K31/11A61P31/04
Inventor 钱卫东付玉婷刘淼李靖原王文静李鑫辰黄杰刘婉婷
Owner SHAANXI UNIV OF SCI & TECH
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