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Application of Huoxiang volatile oil in inhibiting the growth of drug-resistant Escherichia coli

A technology of Escherichia coli and volatile oil, which is applied in essential oils/fragrances, pharmaceutical formulas, fat production, etc., can solve the problems of slowing down bacteria, blocking or solving drug resistance problems, so as to reduce the fatality rate and solve drug-resistant infections Effect

Active Publication Date: 2019-11-12
XINJIANG MEDICAL UNIV
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  • Abstract
  • Description
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Problems solved by technology

In fact, controlling the use of antibacterial drugs can only alleviate bacterial resistance, but cannot fundamentally block or solve the problem of drug resistance
This requires people to continuously develop new antibiotics, but the speed of developing new antibiotics is far behind the speed of bacterial resistance

Method used

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  • Application of Huoxiang volatile oil in inhibiting the growth of drug-resistant Escherichia coli
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  • Application of Huoxiang volatile oil in inhibiting the growth of drug-resistant Escherichia coli

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Embodiment 1

[0020] 1. Determination of extraction and yield of Huoxiang volatile oil grown in Xinjiang:

[0021] After separating and drying the picked Huoxiang flower parts grown in Xinjiang, take 100 g and put it into a 5000 ml retort bottle, add less than 3500 ml of water, and soak for 1 h. According to "Chinese Pharmacopoeia" 2005 edition (a) appendix XD steam distillation method to extract volatile oil, extraction 6-8 h. Since the obtained distillate contains a small amount of water, add a little sodium chloride and refrigerate for 24 hours to separate the water and oil phases, and then separate them with a separatory filter funnel to obtain a yellow, transparent, strong aromatic distillate. The liquid of smell, that is, the volatile oil from the parts of Huoxiang flowers grown in Xinjiang, the calculated volatile oil yield is 0.29% (w / w). Capillary specific gravity method, the volatile oil density of Huoxiang flowers planted in Xinjiang is 0.84 mg / ml.

[0022] 2. Determination of ...

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Abstract

The invention discloses application of agastache rugosus volatile oil to suppression of growth of drug-resistant escherichia coli. A single chemical component, i.e. pulegone, is obtained from an agastache rugosus volatile oil to achieve a better in vitro suppression effect on the growth of human-derived drug-resistant escherichia coli, i.e. human-derived ESBLs-producing escherichia coli. The application has the beneficial effects that the first research on the effect of the agastache rugosus volatile oil on the drug-resistant escherichia coli finds that the growth of the drug-resistant escherichia coli can be suppressed; a main component serving as a drug-resistant suppressing agent is screened from the agastache rugosus volatile oil and then researched; data show that the main monomer component, i.e. the pulegone, of the agastache rugosus volatile oil can suppress the growth of the ESBLs-producing escherichia coli and affect the formation of a biofilm so as to relieve or avoid the drug-resistant infection of the escherichia coli and reduce the fatality rate; a new idea is brought up to solve and treat the human-derived ESBLs-producing escherichia coli; and the application has a great research significance.

Description

technical field [0001] The invention relates to the technical field of application of traditional Chinese medicine extracts, in particular to the application of Huoxiang volatile oil in inhibiting the growth of drug-resistant Escherichia coli. Background technique [0002] At present, bacterial drug resistance has become a serious public health threat and a clinical problem of worldwide concern. The emergence of drug-resistant bacteria has led to a continuous decline in the efficacy of clinically available antibacterial drugs, and the range of drug options has become increasingly limited. In fact, controlling the use of antibacterial drugs can only alleviate bacterial drug resistance, but cannot fundamentally block or solve the problem of drug resistance. This requires people to continuously develop new antibiotics, but the speed of developing new antibiotics is far behind the speed of bacterial drug resistance. As the crystallization of human experience in fighting against...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K133/00
CPCA61K31/122A61K36/532A61K2236/331C11B9/022C11B9/027Y02A50/30
Inventor 宫海燕张晨田树革陈凯李劭昱王学涵
Owner XINJIANG MEDICAL UNIV
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