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Application of Pulsatilla saponin a3 in inhibiting the growth of multidrug-resistant Providencia rettgeri

A technology of Providencia rettgeri and Providencia bacteria, applied in the direction of pharmaceutical formulations, antibacterial drugs, medical preparations containing active ingredients, etc., to solve drug-resistant infections, wide application value, and reduce fatality Effect

Active Publication Date: 2021-08-13
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing literature has not reported that Pulsatilla saponin A3 has antibacterial effect on multidrug-resistant Providencia rettii

Method used

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  • Application of Pulsatilla saponin a3 in inhibiting the growth of multidrug-resistant Providencia rettgeri
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  • Application of Pulsatilla saponin a3 in inhibiting the growth of multidrug-resistant Providencia rettgeri

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Embodiment Construction

[0021] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the content of the present invention, not to limit the present invention.

[0022] Pulsatilla saponin A3, the English name is Anemoside A3 Pulchinenoside A3, the molecular formula is C 41 h 66 o 12 , relative molecular mass is 750.95554, density: 1.31, solubility: soluble in methanol, acetonitrile, ethanol and other solvents, insoluble in petroleum ether. Appearance: white crystalline powder. The source of extraction is Pulsatilla pulsatillae, a plant of Ranunculaceae. The CAS number is 129724-84-1, the CB number is CB42491699, and the molecular structure is as follows:

[0023]

[0024] 1. Drug susceptibility test of Providencia rettgeri

[0025] The present invention takes 5 strains of Providencia rettgeri from Ningbo Women and Children's Hospital as starting strains, and selects ampicillin, ampicillin / sulbactam, cefazolin, c...

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Abstract

The invention discloses the application of Pulsatilla saponin A3 in inhibiting the growth of multidrug-resistant Providencia rettleri. Pine, ceftazidime, tobramycin, piperacillin-tazobactam, ciprofloxacin, levofloxacin, amikacin, co-trimoxazole, cefepime, ertapenem, imipenem, aztreonem The human-sourced Providencia rettgeri of Nan and gentamicin have good in vitro killing effect and inhibit the in vitro growth of multidrug-resistant Providencia rettgeri, and the minimum inhibitory concentration is 125 μg / mL , the minimum bactericidal concentration is 250μg / mL. The invention provides the antibacterial effect of Pulsatilla saponin A3 on multi-drug-resistant Providencia rettgeri, which can alleviate or solve the problem of increased drug resistance of multi-drug-resistant Providencia rettgeri, and is a clinical antibacterial treatment and novel antibacterial agent. Provide a theoretical basis for drug development.

Description

technical field [0001] The invention belongs to the technical field of medicine and food safety, and relates to the application of pulsatilla saponin A3 in inhibiting the growth of multidrug-resistant Providencia rettgeri. Background technique [0002] Providencia rettgeri belongs to the family Enterobacteriaceae and the genus Providencia was first isolated in 1904 by Rettger in chickens similar to fowl cholera. This bacterium can cause urinary tract infection, sepsis and even death. It can also cause potential diarrhea in children and relatively rare eye infections such as keratitis, dacryocystitis, conjunctivitis and other extraintestinal infections. It has also caused many hospital-acquired infections. Outbreaks (Zhang Zhuoran. Clinical Microbiology and Microbiological Testing [M]. 3rd Edition. Beijing: People's Health Publishing House, 2003.136-140.). In addition, traveler's diarrhea, eye infection, bacteremia, urinary tract infection and other diseases caused by the ba...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P31/04
CPCA61K31/704A61P31/04
Inventor 钱卫东何维维刘淼付玉婷高悦李康帆刘婉婷李靖原
Owner SHAANXI UNIV OF SCI & TECH
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