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Application of eugenol to inhibition of growth of Escherichia coli with multi-drug resistance

A technology of Escherichia coli and multi-drug resistance, applied in antibacterial drugs, pharmaceutical formulations, and resistance to vector-borne diseases, etc. The effect of solving the problem of drug-resistant infection and reducing the mortality rate

Pending Publication Date: 2018-11-16
SHAANXI UNIV OF SCI & TECH
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Problems solved by technology

[0006] However, it has been reported that the antibacterial situation of clove extract on human multidrug-resistant Escherichia coli and the antibacterial concentration of eugenol on multidrug-resistant Escherichia coli have not been studied in the relevant literature.

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  • Application of eugenol to inhibition of growth of Escherichia coli with multi-drug resistance
  • Application of eugenol to inhibition of growth of Escherichia coli with multi-drug resistance
  • Application of eugenol to inhibition of growth of Escherichia coli with multi-drug resistance

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Embodiment Construction

[0015] The present invention will be further described in detail below in conjunction with the embodiments. The embodiments are only used to explain the content of the present invention, but not to limit the present invention.

[0016] 1. Drug susceptibility test of human pathogenic E. coli

[0017] The present invention uses 10 human-derived Escherichia coli as the starting strains, and selects ceftriaxone, meropenem, cefepime, minocycline, cefotaxime, ceftazidime, gentamicin, cefazolin, and cefoxitin And azithromycin 10 kinds of commonly used antibiotic susceptibility test strips for susceptibility test.

[0018] Pick the pure colonies that have been cultured for 18-24 hours and dissolve them in 2-5 mL sterile normal saline, and adjust their turbidity to 0.5 McDonnell's turbidity tube. Aseptically draw 50-200 μL of bacterial solution, spread the plate evenly, and place it at room temperature for 3 to 5 minutes. Use sterile tweezers to press the drug sensitive paper sheet (with a...

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Abstract

The invention discloses the application of eugenol to inhibition of the growth of Escherichia coli with multi-drug resistance. Since eugenol shows good in-vitro killing effect on human-derived Escherichia coli with resistance to multiple drugs including ceftriaxone, cefepime, minocycline, cefotaxime, ceftazidime, gentamicin, cefazolin , cefoxitin and azithromycin, can inhibit the growth of Escherichia coli with multi-drug resistance and has a minimum bactericidal concentration of 5.0 [mu]g / mL and a minimum inhibitory concentration of 2.5 [mu]g / mL, the invention provides the inhibitory effect of eugenol on human-derived Escherichia coli with multi-drug resistance. The application of the invention can effectively alleviate or solve the problem of drug-resistant infections of Escherichia coliwith multi-drug resistance, reduces a mortality rate, provides a novel idea for inhibition of human-derived Escherichia coli with multi-drug resistance, and has important practical significance.

Description

Technical field [0001] The invention relates to the technical field of the application of active ingredients of traditional Chinese medicines, in particular to the application of eugenol in inhibiting the growth of multi-drug resistant Escherichia coli. Background technique [0002] Currently, the global public health sector is facing severe challenges. The increasing resistance of bacteria to existing antibiotics and the lack of development of new antibiotics have made the treatment of bacterial infectious diseases more and more difficult. Humans may once again face the dilemma of no medicines available. The emergence of multi-drug resistant bacteria has brought huge challenges to clinical treatment. For example, ineffective treatment not only delays the disease, but also consumes social resources and increases the burden on the country's public finances. At the same time, drug-resistant pathogens increase the incidence and mortality of infectious diseases. [0003] As the cryst...

Claims

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Application Information

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IPC IPC(8): A61K31/085A61P31/04
CPCA61K31/085A61P31/04Y02A50/30
Inventor 钱卫东刘婵婵王婷沈兰芳李永东刘淼卢家兴刘翌超
Owner SHAANXI UNIV OF SCI & TECH
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