Oil-in-water compound antimicrobial cefazolin nanoemulsion medicine

A technology for cefazolin and antibacterial drugs, applied in the field of medicine, can solve the problems of slow drug dissolution rate, prone to abnormal reactions, increased bacterial resistance, etc., and achieves promotion of gastrointestinal absorption, reduction of first-pass effect, and low surface area. The effect of tension

Inactive Publication Date: 2015-02-18
HENAN SOAR VETERINARY PHARMA
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Problems solved by technology

Drugs are mostly administered intravenously or injected intramuscularly. When administered intravenously, local reactions include phlebitis, while intramuscular injection can cause severe pain, and may also have rashes, urticaria, increased eosinophilia, drug fever, and other allergic reactions; Phylin is mainly excreted through the kidneys in the original form, and abnormal reactions are prone to occur in patients with renal insufficiency; oral cefazolin can be absorbed from the gastrointestinal tract, but the absorption is incomplete, the drug dissolution rate is slow, and the bioavailability rate is poor.
In addition, the extensive use of antibiotics is also the direct cause of the increase in strain resistance

Method used

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  • Oil-in-water compound antimicrobial cefazolin nanoemulsion medicine
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[0034] Table 1 Implementation Case Recipe

[0035] Example Cefazolin / g Clove water extract / g Surfactant / g Co-surfactant / g oil / g water / g 1 6 5 25 (EL-40) 5 (ethanol) 13 (isopropyl myristate) 46 2 5.5 4.5 25 (EL-40) 5 (1,2-propanediol) 15 (cinnamaldehyde) 45 3 5 4.5 25 (RH-40) 17 (glycerol) 14 (canola oil) 34.5 4 7 1 25 (RH-40) 20 (ethanol) 16 (soybean oil) 31 5 4.5 6.5 25 (tween 80) 10 (glycerol) 15 (ethyl butyrate) 39 6 5 5 30 (tween 80) 5 (polyethylene glycol 400) 10 (ethyl acetate) 50

[0036] Preparation method: Accurately weigh cefazolin, surfactant and co-surfactant, stir evenly at room temperature (25°C), and then slowly drop into it the distilled water that has been dissolved in clove water extract; with the amount of distilled water When the amount of distilled water added makes the system change from water-in-oil to oil-in-water nanoemulsion, the viscosity of the syste...

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Abstract

An oil-in-water compound antimicrobial cefazolin nanoemulsion medicine is a nanoemulsion medicament with cefazolin and an aqueous clove extract as effective components, and comprises the following components in parts by weight: 1-15 parts of cefazolin, 10-30 parts of a surfactant, 0-25 parts of a co-surfactant, 1-10 parts of aqueous clove extract, 1-20 parts of oil and 20-70 parts of distilled water. By compounding the cefazolin and the aqueous clove extract, the oil-in-water compound antimicrobial cefazolin nanoemulsion medicine is good in medicinal effect and good in antimicrobial effect; a preparation method is very simple; the oil-in-water compound antimicrobial cefazolin nanoemulsion medicine is easier to popularize.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a compound cefazolin antibacterial drug, in particular to an oil-in-water compound cefazolin nanoemulsion antibacterial drug. Background technique [0002] Cefazolin, also known as cefazoline, cephazolin, cefazolin, chemical name is (6R,7R)-3-[(5-methyl-1,3,4-thiadiazole -2-yl)thiomethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]octane -2-en-2-carboxylic acid, is the first generation of cephalosporin antibiotics, can resist bacteria including Staphylococcus and Streptococcus that can produce penicillinase and methicillin, and some Escherichia coli, Klebsiella Klebsiella pneumoniae and Bacillus mirabilis. Cephalosporins prevent bacterial growth by disrupting the synthesis of peptidoglycan in the bacterial cell wall. Clinically, it is widely used in respiratory tract, urethra, pneumonia, cholecystitis, liver abscess, peritonitis, pelvic inflammatory ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K36/61A61P31/04A61K31/546
Inventor 孙江宏阮心洁
Owner HENAN SOAR VETERINARY PHARMA
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