3results about How to "Overcome barriers" patented technology

The application discloses an ultrasonic driving nanorobot and a preparation method and application thereof, and the preparation method comprises the following steps: reacting Pd NPs, 4-mercapto phenylacetic acid and polyacrylic acid, adding tetraethyl orthosilicate and ammonia, and stirring to obtain PdSiO2; reacting titanium chloride solution, sodium bicarbonate solution and PdSiO2, and performing amino modification to obtain NH2-TiO2-Pd-SiO2; connecting COOH-PEG-TPP and COOH-PEG-RGD to the surface of NH2-TiO2-Pd-SiO2, and removing SiO2; the nanorobot can penetrate the dense extracellular matrix in a tumor microenvironment and precisely target a diffuse lesion, and further has the functions of catalytically generating active oxygen free radicals and regulating a tumor microenvironment, so that the oxidation-reduction / metabolic balance of the TME is changed, immunogenic cell death is induced, and the anti-tumor immune response is further enhanced.

The application relates to a sodium hypophosphite salt modified phosphorus-containing dendrimer with anti-inflammatory activity and a preparation method and application thereof, and a structural formula of the phosphorus-containing dendrimer is as follows: The phosphorus-containing dendrimer prepared by the application can realize intracellular delivery of various proteins, has the advantages of good biocompatibility and high cytoplasm delivery efficiency, and has potential application value in the field of developing protein drugs for intracellular disease targets.

This invention relates to the field of pharmaceutical technology, specifically to an antibacterial and health-promoting compound gel and its preparation method. The preparation method of the antibacterial and health-promoting compound gel is characterized by the following steps: mixing pepper volatile oil and tea oil as the oil core, and using whey protein isolate and pectin complex as the wall material to prepare oil-loaded microcapsules; dispersing gellan gum and xanthan gum in purified water containing β-glycyrrhizic acid, adding a concentrated aqueous extract obtained by microwave-assisted extraction of Polygonum cuspidatum, Portulaca oleracea, Cnidium monnieri, and Glycyrrhiza uralensis in a weight ratio of 4:2:2:1, and stirring evenly to obtain an aqueous matrix; adding the oil-loaded microcapsules to the aqueous matrix under continuous high-speed shearing, and simultaneously adding nano-sized calcined oyster shell powder to obtain a biphasic gel mixture; adding ε-polylysine and menthol-β-cyclodextrin inclusion complex to the biphasic gel mixture, and stirring to form a biphasic gel system. This application solves the problems of unstable essential oils, easy volatility, and uncontrollable release behavior in the prior art.