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Application of ursolic acid in inhibiting growth of multi-drug-resistance enterobacter cloacae

A technology of Enterobacter cloacae and Enterobacter cloacae, applied in the field of application of ursolic acid in inhibiting the growth of multidrug-resistant Enterobacter cloacae

Inactive Publication Date: 2019-09-27
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no literature report that ursolic acid has antibacterial effect on multi-drug resistant Enterobacter cloacae

Method used

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  • Application of ursolic acid in inhibiting growth of multi-drug-resistance enterobacter cloacae
  • Application of ursolic acid in inhibiting growth of multi-drug-resistance enterobacter cloacae
  • Application of ursolic acid in inhibiting growth of multi-drug-resistance enterobacter cloacae

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Embodiment Construction

[0020] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the content of the present invention, not to limit the present invention.

[0021] Ursolic acid is also known as ursolic acid and ursolic acid. The English name is Ursolic Acid. The molecular formula is C30H48O3, the molecular weight is 456.68, the CAS number is 77-52-1, and the melting point is 283-285°C. The molecular structure is:

[0022]

[0023] 1. Drug susceptibility test of Enterobacter cloacae

[0024] The present invention uses 1 strain of Enterobacter cloacae as the starting strain, selects cefazolin, cefotaxime, brogmentine, meropenem, ofloxacin, levofloxacin, ciprofloxacin, cefoxetine, and minocycline Antimicrobial susceptibility tests were carried out on 16 kinds of commonly used antibiotics, such as azithromycin, imipenem, piperacillin, azithromycin, nitrofurantoin, and gentamicin.

[0025] The pure colonies picked a...

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Abstract

The invention discloses application of ursolic acid in inhibiting growth of multi-drug-resistance enterobacter cloacae. According to a good in-vitro killing function of ursolic acid upon anthropogenic multi-drug-resistance enterobacter cloacae which resists to cefazolin, cefotaxime, aupmentn, meropenem, ofloxacin, levofloxacin, ciprofloxacin, cefoxitin, minocycline, imipenem, piperacillin, azithromycin and macrodantin, growth of multi-drug-resistance enterobacter cloacae can be inhibited, the lowest sterilization concentration is 0.6mg / mL, and the lowest antibacterial concentration is 0.3mg / mL. The invention discloses an inhibition function of the ursolic acid upon the multi-drug-resistance enterobacter cloacae, and the ursolic acid is capable of effectively alleviating or solving the drug-resistance infection problem of the multi-drug-resistance enterobacter cloacae and reducing the case fatality rate, provides new ideas for inhibiting anthropogenic multi-drug-resistance enterobacter cloacae, and has great practical significances.

Description

technical field [0001] The invention belongs to the technical field of application of active ingredients of traditional Chinese medicines, and relates to the application of ursolic acid in inhibiting the growth of multidrug-resistant Enterobacter cloacae. Background technique [0002] Enterobacter cloacae belongs to the Enterobacteriaceae genus Enterobacter, is a Gram-negative stubby bacillus, has become one of the important nosocomial infection opportunistic pathogenic bacteria, mainly attacking people with weak health or suppressed immunity, especially It is a critically ill patient, a patient in the intensive care unit who has been hospitalized for a long time. It can cause multi-system infections, respiratory tract infection is the most common, and it can also cause sepsis, urinary tract infection, wound infection and urinary tract infection; however, the widespread use and overuse of antibiotics has led to the continuous increase of bacterial resistance, leading to bact...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P31/04
CPCA61K31/56A61P31/04
Inventor 钱卫东付玉婷刘淼杨敏张家宁孙照欢李鑫辰
Owner SHAANXI UNIV OF SCI & TECH
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