12 results about "Antibiotic misuse" patented technology

The invention discloses application of triptolide ketone in preparation of a medicine for treating sepsis lung injury, and belongs to the technical field of biological medicine. Aiming at the problems that traditional chemical synthetic drugs may cause a large amount of sequelae and antibiotic abuse, and triptolide may cause liver and kidney injury when treating sepsis, research finds that triptolide can be used for treating sepsis lung injury, and can be used for treating sepsis lung injury. According to the application, the protein expression level of HIF-1alpha in proinflammatory activated macrophages is lowered, so that aerobic glycolysis is inhibited, and the effect of treating sepsis lung injury is achieved. Compared with the triptolide alcohol, the triptolide ketone does not cause liver and kidney injury while playing a role in treating the sepsis lung injury, and the curative effect of the triptolide ketone is equivalent to that of the existing medicine 2ME2 for treating the sepsis lung injury, so that the triptolide ketone has important application potential clinically, and can be used for preparing medicines for treating the sepsis lung injury. And a theoretical basis is provided for clinically developing medicines for treating sepsis lung injury.

A new antibacterial peptide of Japanese eel A1 Cath2b 143‑174 and its application, belong to the field of biotechnology. The antibacterial peptide is a Cathelicidin family antibacterial peptide of Japanese eel A1 The 143-174 amino acid fragment of Cathelicidin 2b is named as Cath2b A1 Cath2b 143‑174 , and the amino acid sequence is shown as SEQ ID NO. 3. The antibacterial peptide has high inhibition / killing activity on various aquatic pathogenic bacteria, has excellent thermal stability and salt ion tolerance, and has no obvious toxicity to host cells; it plays a bactericidal role by destroying the bacterial cell membrane, and can also attract host immune cells to enhance immunity. The antibacterial peptide can be applied in the preparation of aquatic animal bacterial disease prevention and control drugs. It can solve the problems of drug resistance and drug residue caused by the abuse of traditional antibiotics, and is convenient to prepare, has strong adaptability, and is suitable for the prevention and control of bacterial diseases of aquatic animals.

The invention discloses a strain of leuconostoc mesenteroides V7, and the microbial preservation number is CGMCC (China General Microbiological Culture Collection Center) No.34824. The leuconostoc mesenteroides V7 disclosed by the invention is applied to products for inhibiting source avian pathogenic escherichia coli. The leuconostoc mesenteroides V7 disclosed by the invention has an inhibition effect on avian pathogenic escherichia coli, so that the leuconostoc mesenteroides V7 can be used for replacing antibiotics in poultry production and breeding to treat avian pathogenic colibacillosis. The invention provides a novel antibiotic substitute, which can obviously improve the infection condition of avian pathogenic escherichia coli in poultry bodies and avoid the problems of antibiotic abuse and bacterial drug resistance as much as possible.

The invention relates to the technical field of microorganisms, in particular to a method for reducing the dosage of antibiotics for treating clostridium perfringens infection, a bactericidal composition, bacteriophage and application. According to the method, the clostridium perfringens bacteriophage RDP-CP-2310008 and one or more antibiotics are used in a combined mode, and the clostridium perfringens bacteriophage RDP-CP-2310008 and the one or more antibiotics are used in a combined mode. The clostridium perfringens bacteriophage RDP-CP-2310008 is preserved in the China General Microbiological Culture Collection Center on November 29, 2023, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) NO.45778. The clostridium perfringens bacteriophage RDP-CP-2310008 can be used The bactericidal composition is prepared from the following effective components: the clostridium perfringens bacteriophage RDP-CP-2310008, and one or more antibiotics used for resisting the clostridium perfringens. The invention further discloses application of the clostridium perfringens phage RDP-CP-2310008 in preparation of a medicine for preventing and / or treating clostridium perfringens infection. The invention provides and verifies that the specific bacteriophage is combined with the antibiotics for the first time, so that the dosage of the antibiotics can be greatly reduced and can be up to 64 times, and a brand-new path is provided for solving the problem of abuse of the antibiotics in the breeding industry.

The application discloses an antagonistic bacterium of pathogenic shewanella of Apostichopus japonicus and application thereof, and belongs to the technical field of aquatic microorganisms. Gilvus japonicus The antagonistic bacterium is separated from the intestinal tract of healthy Apostichopus japonicus and is identified as Japanese Yellow Sea Oceanic Bacterium (Shewanella japonica), has no beta-hemolysis characteristic, is safe and non-toxic to Apostichopus japonicus, and can significantly antagonize the pathogenic bacterium Shewanella of Apostichopus japonicus skin rot syndrome. The application also discloses application of the antagonistic bacterium, which can be prepared into an aquatic microecological preparation for preventing and treating the skin rot syndrome of Apostichopus japonicus, and is applied through intraperitoneal injection or immersion, so that the survival rate of Apostichopus japonicus under exposure of the pathogenic bacterium is significantly improved. The strain has strong salt and alkali resistance, tolerances to various antibiotics and chemical drugs, and strong environmental adaptability, can be applied to the cultivation of Apostichopus japonicus to replace traditional antibiotics, effectively solves the problems of food safety and environmental pollution caused by the abuse of antibiotics, and has good industrial application prospect.

The present invention relates to an antimicrobial adjuvant containing a biphenyl derivative compound as an active ingredient, and a technology of various uses thereof. The compound of the present invention reduces the dosage of polymyxin antibiotics, which are administered to inhibit the proliferation of gram-negative bacteria, by enhancing the sensitivity of the gram-negative bacteria with respect to the polymyxin antibiotics, is concomitantly administered with the polymyxin antibiotics to show gram-negative bacteria growth inhibitory and killing effects, may notably reduce side effects such as nephrotoxicity, and may prevent or treat sepsis and septic shock due to antibiotic overuse.

This invention belongs to the field of shrimp farming technology, specifically relating to a method for raising Litopenaeus vannamei larvae using bioflocs. The method includes the following steps: (1) preparing raceway-shaped bioflocs; (2) preparing functional bioflocs; and (3) raising mysids and larvae; and raising adult larvae. This invention provides an effective method for raising Litopenaeus vannamei larvae without the use of antibiotics, solving the problem of antibiotic abuse during the larval stage, and is of great significance for promoting the green and healthy development of the shrimp larval industry.

The present application relates to the field of medical detection, in particular to a fluorescence sensing composition, a fluorescence sensing film and application thereof. Through screening a variety of fluorescence indicators and combinations thereof, a simple and cost-effective indicator formula is finally obtained. Based on the formula, through optimizing the preparation process, a high-efficiency fluorescence sensing film resistant to moist heat sterilization is developed. After inoculating gram-negative bacilli, gram-positive cocci and yeast-type fungi representative quality control strains into the microorganism culture bottle prepared based on the film, through fluorescence curve determination of the full-automatic microorganism culture system, gram staining, microorganism mass spectrum identification and other experiments, it is proved that the fluorescence sensing film has excellent detection performance. The fluorescence sensing film proposed in the present application can be applied to the detection of clinical microorganisms, which can provide technical support for the diagnosis of bloodstream infections, and has important significance for curbing the abuse of antibiotics and improving the prognosis of patients with bloodstream infections.

This application discloses an intelligent monitoring method, electronic device, and medium for porcine reproductive and respiratory syndrome (PRRS) based on multimodal perception and semantic retrieval. The method includes: real-time acquisition and preprocessing of multimodal data from pigs in a pigsty; construction of a PRRS knowledge graph; vectorization of data for different modalities to obtain query vectors; filtering candidate rules based on keyword matching; calculating a comprehensive score based on the candidate rules; sorting the comprehensive scores in descending order and outputting the top K rule texts; generating initial results based on a large language model; validating the initial results based on logical rules in the knowledge graph; and outputting the results after successful validation. This invention employs multimodal data fusion and a RAG architecture, combined with multi-sensor methods to capture early symptoms of PRRS, achieving standardized monitoring and reducing misdiagnosis and antibiotic overuse. It also supports dynamic updates of the knowledge base, full-process offline deployment to ensure data security, and rule validation to reduce medication risks.

The present application relates to blood culture bottle technical field, especially to composition and its application in the preparation of microbial culture medium, the present application combines yeast extract powder, soybean peptone and pancreatic casein peptone into nitrogen source, forming aerobic and anaerobic culture medium for clinical pathogenic microorganism culture, through comparison and verification, the aerobic and anaerobic culture medium added with the composition as described above is superior to prior art and other formula in culture speed and biomass accumulation in the growth experiment of 9 aerobic bacteria and 7 anaerobic bacteria, which shows that the composition as described above can effectively promote the performance of blood culture product, improve the ability of clinical blood stream infection detection, curb antibiotic abuse and save patients' lives.

The invention relates to an application of L-tryptophan in reversing T-2 toxin induced escherichia coli pan-drug resistance. T-2 toxin can induce Escherichia coli ATCC 25922 under the concentration of 10 ng / mL to generate pan-drug resistance, and failure to various antibiotics is difficult to deal with by the existing means. According to the invention, the L-tryptophan is exogenously added, so that the sensitivity of T-2 toxin induced pan-drug-resistant escherichia coli to beta-lactam antibiotics can be specifically recovered. The L-tryptophan is exogenously added, so that the content of bacterial biofilms can be reduced, and the sensitivity of bacteria to antibiotics can be improved. L-tryptophan is natural amino acid and is high in biocompatibility and low in toxicity, a foundation is laid for control of drug-resistant bacteria and reasonable use of antibiotics in a T-2 toxin pollution scene, drug-resistant bacteria transmission and antibiotic abuse can be reduced, higher safety and operability are achieved, and great significance is achieved on treatment of drug-resistant infection.

The invention relates to the technical field of microorganisms, and provides a bacteriophage perforin HolKpV318 with a broad-spectrum antibacterial effect and application of the bacteriophage perforin HolKpV318. The invention provides a potential novel antibacterial strategy aiming at the clinical problem of increasingly severe multi-drug-resistant klebsiella pneumoniae infection caused by antibiotic abuse at present, so as to overcome the defect that the traditional antibiotic treatment is invalid or poor in effect; the invention provides the perforin protein (HolKpV318) with efficient and specific klebsiella pneumoniae splitting capability, and the protein can form a pore channel on a klebsiella pneumoniae cell membrane to destroy the integrity of a bacterial structure so as to cause the death of target bacteria, so that a brand new biological preparation choice is provided for solving the problem of drug-resistant bacterium infection.