108 results about "Quinolizidines" patented technology

To provide a cation-dyeable polyester fiber structure, a production method of the same, and a uniform for medical use.SOLUTION: A cation-dyeable polyester fiber structure includes a cationic dye, a quinoline compound, and an ultraviolet absorber, where 0.03 mass% or more and 0.80 mass% or less of the quinoline compound is included to a mass of the cation-dyeable polyester fiber structure, a color difference ΔE between before and after irradiating the cation-dyeable polyester fiber structure with ultraviolet carbon arc lamplight is 2.0 or lower, and an antibacterial activity value A50 after 50 times of high temperature acceleration washing is larger than a standard cloth growth value F in an antibacterial evaluation method described in an SEK mark textile product certification standard.SELECTED DRAWING: None

The present invention provides a fiber structure having excellent antibacterial properties and washing durability, and a method for producing the same. [Solution] A textile structure having polyamide fibers and containing a dye, a quinoline-based compound, and a phenol derivative, wherein the textile structure contains 0.04% by mass or more of the quinoline-based compound relative to the mass of the textile structure, and even after 10 standard washes in accordance with the "SEK Mark Textile Product Washing Method," the textile structure contains 0.04% by mass or more of the quinoline-based compound relative to the mass of the textile structure, and 0.20% by mass or more and 4.00% by mass or less of the phenol derivative relative to the mass of the textile structure.

The application discloses a quinoline small molecule blended modified polymer dielectric material and a preparation method and application thereof, and belongs to the technical field of capacitor films. The preparation raw materials comprise quinoline derivatives, polymethyl methacrylate, styrene-methyl methacrylate copolymer, polyetherimide, polypropylene and N-methyl pyrrolidone solution, and the preparation steps comprise blending and film preparation. The blending solution or eutectic mixture is prepared through blending, and the polymer dielectric film is prepared through a flow casting method or bidirectional stretching. The prepared quinoline small molecule blended modified polymer dielectric film has excellent electrical properties, can reduce the leakage current of the polymer material, has high DC breakdown field strength, high energy storage density and low energy loss, and is easy to realize large-scale production.

The present invention relates to a Ru-Ni bimetallic catalyst for the selective hydrogenation of a quinoline organic hydrogen storage carrier, and a preparation method therefor and the use thereof. In the catalyst, carbon nitride is used as a carrier, and metal nanoparticles Ru and Ni serve as active components and are jointly loaded on the carbon nitride carrier; and the carbon nitride is prepared by mixing carbon tetrachloride, ethidene diamine and nano-silica, reacting same to obtain a carbon nitride polymer, then calcining same at 750-850ºC, performing a desilicification treatment, and then filtering and drying same. The catalyst provided in the present application has good catalytic hydrogenation performance in the selective hydrogenation of the quinoline organic hydrogen storage carrier and can achieve the omission of a solvent in a reaction system; the reaction is simple, green and environmentally friendly, and the gravimetric hydrogen storage density of the system can be maximally ensured when a quinoline compound is used as an organic hydrogen carrier; moreover, the catalyst also has a good cycling stability.

Disclosed is a quinoline compound and a use thereof. A quinoline derivative of the present invention is a compound having phosphodiesterase 3A (PDE3A) inhibitory activity, has important potential therapeutic value, and is used in the treatment of cerebrovascular diseases or in dementia drugs.

This invention provides an aminoisoquinoline derivative and its application in the preparation of antiviral drugs. The invention reveals that the aminoisoquinoline derivative exhibits significant inhibitory effects against various RNA and DNA viruses, demonstrating broad-spectrum activity. This small-molecule inhibitor has low toxicity and does not affect the normal growth of host cells. It shows good antiviral efficacy even at low concentrations. The results of this invention indicate that the compound has the potential to be used in the preparation of antiviral drugs and has promising clinical application prospects.

The application belongs to the field of chemical medicines, and particularly relates to a quinoline compound, a preparation method and use thereof and a pharmaceutical composition thereof. The application provides a quinoline compound shown in formula I, which has excellent DNA methyltransferase 1 (DNMT1) inhibitory activity and good selectivity, can be used as a novel DNMT1 inhibitor, and provides a new option for drug development and application of diseases driven by DNMT1. Formula I.

The present invention relates to quinoline-based compounds. The compounds of the invention are suitable for the prevention and / or treatment of a disease such as a helminthic infection. The compounds of the invention are in particular suitable for the long-term prevention and / or treatment of a disease. Further, the invention relates to a pharmaceutical composition which can also be used to prevent and / or treat a disease, in particular in long-term.

The present invention relates to compounds of formula (I) which are inhibitors of activin receptor-like kinase 5 (ALK5) and related uses.

Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

The application belongs to the technical field of rubber, and particularly relates to an environment-friendly weather-resistant high-wear-resistance handrail belt rubber material and a preparation method thereof. The rubber material comprises, in terms of weight parts, 80-95 parts of styrene-butadiene rubber, 5-20 parts of butadiene rubber, 70-90 parts of carbon black, 6-9 parts of active agent, 3-5 parts of environment-friendly paraffin oil or naphthenic oil, 4-7 parts of anti-aging agent composition, 1-2 parts of accelerator and 1.5-2.5 parts of vulcanizing agent. The anti-aging agent composition is a combined system of p-phenylenediamine anti-aging agent and quinoline anti-aging agent. Through the synergistic effect of the rubber combined system, the gradation optimization of the reinforcing system and the synergistic effect of the anti-aging agent composition, the application simultaneously realizes high wear resistance, excellent weather resistance (ozone and thermal oxygen aging resistance), low-temperature toughness at-45 DEG C and environment-friendly performance of PAHs <= 10 ppm, and the comprehensive performance is significantly better than that of the existing handrail belt material, and the eight-year service life requirement of public places can be met.

The invention provides an application of a quinoline derivative as shown in a formula (1) in preparation of drugs for treating acute lung injury and resisting inflammation. It is found for the first time that the quinoline derivative has the function of a P2Y6R antagonist, has an obvious antagonistic effect on P2Y6R-related inflammation and can be used for preparing P2Y6R-related anti-inflammatory drugs.

The invention belongs to the technical field of pesticide chemistry, and relates to a quinoline derivative containing a piperazine structure and a preparation method and application thereof. The invention provides a quinoline derivative containing a piperazine structure, and the quinoline derivative has broad-spectrum inhibitory activity on phytopathogens such as plant pathogenic fungi, especially has excellent inhibitory activity on valsa mali, sclerotinia sclerotiorum, botrytis cinerea, gaeumannomyces graminis and magnaporthe oryzae. The bactericide is expected to be developed into a novel green bactericide which is efficient, safe, economical and environment-friendly.

The application relates to the preparation field of quinoline compounds and discloses a method for preparing a quinoline compound shown in formula (I), which comprises the following steps: in the presence of inert high-boiling-point polyether solvents, substituting a compound shown in formula (III) with 3,5-dichloroaniline to obtain a compound shown in formula (II), and then performing ring closure reaction to obtain the compound shown in formula (I), wherein X1, X3, X4, X5 and X6 are each independently -CN or -COOR'; R' is C1-C4 alkyl; wherein X1 is same as at least one of X3, X4, X5 and X6; X3 and X4 are same or different, X5 and X6 are same or different; X2 is a hydroxyl group or an amino group; R1 and R2 are each independently hydrogen or C1-C4 alkyl; and R1 and R2 are same or different. The method has the advantages of low reaction temperature, low cost and high yield, and is beneficial to industrialization.

The application discloses a catalytic synthesis method of chiral polysubstituted hydrogenated quinoline compounds, and belongs to the field of organic synthesis. The application comprises the following steps: at 0-40 DEG C, alcohol or halogenated alkane is used as a solvent, a copper metal catalyst and a chiral ligand are added, and reaction is carried out under nitrogen protection for 0.5-2 hours; the temperature is lowered to-60-0 DEG C; then, o-aminophenyl nitrone, propargyl alcohol ester and alkali are sequentially added; and reaction is carried out for 6-48 hours, so as to obtain a chiral polysubstituted hydrogenated quinoline compound shown in formula 1 or 2. The application realizes, for the first time, synthesis of chiral polysubstituted hydrogenated quinoline compounds by using o-aminophenyl nitrone and propargyl alcohol ester as reactants, and by using a cheap copper metal catalyst and a chiral ligand, the method is simple in operation, low in cost, and has excellent enantioselectivity and diastereoselectivity.

The application discloses a 4-oxoquinoline derivative with ferroptosis inhibiting activity and a preparation method and application thereof, and belongs to the technical field of medicines. The application provides a compound shown in general formula I or a pharmaceutically acceptable salt, isomer, polymorph, or pharmaceutically acceptable solvate thereof, which has the effect of inhibiting ferroptosis, and further treating and / or preventing renal fibrosis, thereby providing a new scheme for treating and / or preventing renal fibrosis. The application provides application of the compound shown in general formula I or the pharmaceutically acceptable salt, isomer, polymorph, or pharmaceutically acceptable solvate thereof in preparation of a ferroptosis inhibitor and in preparation of a medicine for treating and / or preventing renal fibrosis, and the application field of the compound shown in general formula I or the pharmaceutically acceptable salt, isomer, polymorph, or pharmaceutically acceptable solvate thereof is expanded.

The invention discloses application of a quinoline compound to prevention and treatment of ralstonia solanacearum, and belongs to the technical field of prevention and treatment of plant bacterial wilt. The quinoline compound is 1-ethyl-6-fluoro-7-morpholinyl-3-(3-(p-tolyl)-1, 2, 4-oxadiazole-5-yl) quinoline-4 (1H)-ketone, and it is found for the first time that the 1-ethyl-6-fluoro-7-morpholinyl-3-(3-(p-tolyl)-1, 2, 4-oxadiazole-5-yl) quinoline-4 (1H)-ketone has very strong inhibitory activity on Ralstonia solanacearum, and the quinoline compound can be used for preparing a compound for inhibiting Ralstonia solanacearum. Experiments show that the MIC of the 1-ethyl-6-fluoro-7-morpholinyl-3-(3-(p-tolyl)-1, 2, 4-oxadiazole-5-yl) quinoline-4 (1H)-ketone to ralstonia solanacearum is 5 [mu] g / mL within 24 h, which is equivalent to that of benziothiazolinone, so that the 1-ethyl-6-fluoro-7-morpholinyl-3-(3-(p-tolyl)-1, 2, 4-oxadiazole-5-yl) quinoline-4 (1H)-ketone can be used for preventing and treating plant bacterial wilt, and a new candidate compound is provided for development of ralstonia solanacearum bactericides.

The invention provides a method for synthesizing a quinoline compound by catalytic dehydrogenation of a tetrahydroquinoline compound, which comprises the following steps: adding a bivalent palladium catalyst, a Bronsted acid, an additive and an oxidant into an organic solvent, and then adding the tetrahydroquinoline compound for reaction to obtain the quinoline compound, the additive is sodium tetrakis (3, 5-bis (trifluoromethyl) phenyl) borate; the oxidizing agent is tert-butyl hydroperoxide or hydrogen peroxide. According to the method, the quinoline compound can be efficiently synthesized through catalytic dehydrogenation of the tetrahydroquinoline compound, the reaction conditions are mild, operation is easy, the catalyst cost is low, and the method has high substrate functional group tolerance and a wide substrate application range.

Provided are cyanoquinoline targeted protein degradation molecules, methods of making and uses thereof. In particular, the application relates to compounds of general formula (I), methods of making the same, and pharmaceutical compositions containing the same, and uses thereof as androgen receptor targeted protein degradation chimeras, in the manufacture of medicaments for the treatment of diseases related to androgen receptor regulation, including prostate cancer, breast cancer, Kennedy's disease, wherein the substituents in general formula (I) are the same as defined in the specification.

The invention relates to a quinoline compound or a pharmaceutically acceptable salt thereof, and a preparation method and application thereof. According to the compound, a quinoline mother nucleus is used as a skeleton, and target selectivity and binding efficiency are improved through multi-substituent collaborative design; a novel structure type and a practical scheme are provided for research and development of CDK9 targeted anti-cancer drugs, and important clinical value and application prospects are achieved.

This invention belongs to the field of pharmaceutical technology, specifically relating to the use of a 4-(4-diethylamino-1-methylbutanamino)-7-chloroquinoline derivative or its pharmaceutically acceptable salt, or its tautomer, meso compound, racemic compound, enantiomer, diastereomer, or pharmaceutical composition thereof as an active ingredient in the preparation of drugs for the prevention or treatment of obesity and obesity-related metabolic diseases. The 4-(4-diethylamino-1-methylbutanamino)-7-chloroquinoline derivative of this invention has significant therapeutic effects on obesity and related metabolic diseases. In obese mice induced by a high-fat diet and high-fructose water intake, gavage administration for 6 weeks showed that, compared with the high-fat control group, it inhibited more than 70% of the mice's weight gain, with no significant difference in food intake and water intake, demonstrating good clinical application prospects.

The invention belongs to the technical field of biological medicines, and particularly relates to a furo-quinoline dictamnine derivative as well as a preparation method and application thereof. The compound is novel and stable in structure, has a remarkable anti-cancer effect, particularly has a relatively high inhibition rate on NCI-H460 and 786-O tumor cells, has relatively low IC50, has a remarkable anti-tumor cell effect, and has a relatively good application prospect in the aspect of anti-cancer treatment. Besides, the preparation method of the furo-quinoline dictamnine derivative has the advantages of wide substrate application range, good functional group compatibility, mild reaction conditions, simplicity and convenience in operation and the like, can be used for large-scale industrial production, and has wide application value in the aspect of developing anti-cancer drugs.

The invention belongs to the technical field of intelligent packaging materials, and particularly relates to a temperature indication packaging film and a preparation method and application thereof. The packaging film is of a multi-layer composite structure and comprises a transparent outer layer, a functional layer, a blocking layer and an inner layer. The functional layer comprises a flexible polymer matrix as well as a temperature-triggered microcapsule, a solid developing reagent and a reducing agent which are dispersed in the flexible polymer matrix; the microcapsule takes polyurea / polyurethane as a capsule wall, and a capsule core is a phase change medium with a specific melting point and a bivalent copper salt solution. When the environment temperature exceeds a set threshold value, the phase change medium is melted to cause the microcapsule to break, and the released copper ions are reduced and are complexed with the biquinoline compound to generate a stable purple red complex, so that an overtemperature event is irreversibly indicated. The packaging film can be directly used for cold chain packaging of food, medicine or cosmetics, and an integrated monitoring solution which does not need to be externally labeled, is low in cost and high in reliability and can truly reflect the temperature history in the package is achieved.

The application discloses a method for extracting phosphorus and reducing aluminum in a hemihydrate-dihydrate wet-process phosphoric acid process, and belongs to the technical field of the wet-process phosphoric acid. The method is characterized in that: after phosphorite and return acid are uniformly mixed, hemihydrate acidolysis reaction is carried out in the presence of concentrated sulfuric acid, a mixed slurry of stable hemihydrate calcium sulfate crystals and intermediate acid is obtained, then a hydroxyquinoline compound is added, and after continuous reaction, hemihydrate gypsum and intermediate acid with low Al2O3 content can be obtained by filtration; dihydrate gypsum can be obtained by carrying out dihydrate conversion reaction of the hemihydrate gypsum in the presence of concentrated sulfuric acid. The method couples a chemical precipitation method in the hemihydrate-dihydrate wet-process phosphoric acid acidolysis process, can reduce the Al2O3 content in the intermediate acid by the chemical precipitation method, the generated precipitate can be filtered together with the phosphogypsum, and the separation of impurities is easy to realize; meanwhile, the generated precipitate can promote crystal growth in the dihydrate conversion reaction of the hemihydrate gypsum, uniform and bulky dihydrate calcium sulfate crystals are obtained, the washing and filtering performance of the filter cake is improved, and the phosphorus yield is increased.

3H-pyrazolo[4,3-f]quinoline compounds that inhibit interferon gene-stimulating factor (STING); compositions comprising the same compounds; and their use for the treatment of STING-related diseases, such as STING-related inflammatory diseases, autoimmune diseases, diabetes, cancer, traumatic brain injury, and fibrosis.

The application discloses a synthesis method of an alkyl and aryl containing benzoquinoline compound and belongs to the technical field of organic synthesis. The technical scheme of the application is characterized by the following specific steps: aromatic aldehyde compound 1, beta-naphthylamine compound 2 and tertiary aliphatic amine compound 3 are dissolved in a solvent, iodine reagent and an oxidizing agent are then added, and the target product, the alkyl and aryl containing benzoquinoline compound, is prepared by reacting at 110-130 DEG C. The synthesis process is simple and efficient, the benzoquinoline compound is directly prepared by one-pot cascade reaction without transition metal catalysis, the raw material catalyst is cheap and easy to obtain, the reaction condition is mild, the operation is simple, the method is suitable for commercial and large-scale industrial production, the substrate is widely applicable, and the alkyl substituent group is ingeniously introduced by using the tertiary aliphatic amine compound as the raw material.

The present invention provides novel quinoline compounds that are inhibitors of mitochondrial RNA polymerase for treating various diseases such as cancer and others associated with metabolic disorders and mitochondrial dysfunction.

The invention provides a quinoline derivative compound as well as a preparation method and application thereof. The structural formula of the quinoline derivative compound is shown in the specification. The quinoline derivative compound shows remarkable safener activity at a low application dosage, can effectively relieve phytotoxicity of herbicides to crops, shows a good detoxification effect, and remarkably promotes growth recovery of the crops. Compared with existing safeners such as cyclopropanesulfonamide and the like, the quinoline derivative compound disclosed by the invention has higher safety and more excellent detoxification efficiency, particularly has an outstanding relieving effect on crop phytotoxicity caused by p-hydroxyphenylpyruvate dioxidase inhibition herbicides, and can guarantee normal growth and development of crops.

The invention provides a quinoline anti-aging agent and a preparation method thereof, and belongs to the technical field of fine chemical engineering. The preparation method of the quinoline anti-aging agent comprises the following steps: enabling 2, 4-dimethyl-3-pentene-2-amine to react with 4-bromophenylaniline or bis (4-bromophenyl) amine of which the amino group is protected, so as to obtain a quaternary amine anti-aging agent; methylating the quaternary amine anti-aging agent, and removing an amino protecting group to obtain the quinoline anti-aging agent. The quinoline anti-aging agent prepared by the preparation method disclosed by the invention is used in the field of rubber, not only has a better ozone protection effect, but also can improve the phenomenon that the anti-aging agent is easy to migrate out and discolor in a rubber product.