Compound liquorice tablet and preparation process thereof

A technology for compound licorice tablets and licorice extract powder is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Licorice tablets have problems such as poor clinical efficacy and unstable production process, and achieve the effect of strong expectorant effect, good clinical efficacy and reduction of loss.

Inactive Publication Date: 2015-03-04
宁夏启元国药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After oral administration, a small amount of morphine in the opium powder is absorbed through the gastrointestinal tract, and then enters the liver through the portal vein. After the liver metabolizes, most of the morphine has been lost, which eventually leads to poor clinical efficacy of compound licorice tablets.
[0004] 2. In Compound Licorice Tablets, camphor and star anise oil have a special stench. Most users can’t accept it or experience nausea and vomiting. Therefore, oral administration is changed to swallowing, which also seriously affects its therapeutic effect.
[0005] 3. In the preparation of traditional compound licorice tablets, β-cyclodextrin is mostly used to clathrate two components such as camphor and star anise oil, which greatly reduces the odor of camphor and star anise oil. However, this The way of inclusion also causes a large loss of volatile components, thereby reducing the efficacy of the drug
Moreover, the inclusion process conditions of β-cyclodextrin are relatively strict, and the production process is unstable, which affects the quality of the product

Method used

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  • Compound liquorice tablet and preparation process thereof
  • Compound liquorice tablet and preparation process thereof
  • Compound liquorice tablet and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]

[0040] Preparation Process:

[0041] (1) After camphor is dissolved in star anise oil, it is added in calcium hydrogen phosphate, stirred and mixed evenly, and placed for 48 hours to obtain adsorbate powder;

[0042] (2) Take licorice extract powder, opium powder, sodium benzoate, acesulfame potassium and powdered sugar by weighing the weight of raw and auxiliary materials in the prescription, grind them into fine powder respectively, cross 120 mesh sieves, and set aside;

[0043] (3) Add opium powder, sodium benzoate, sugar powder and acesulfame potassium to the licorice extract powder in equal increments, mix well to obtain a mixture, add the adsorbent powder prepared in (1), and then add talcum powder , Micropowder silica gel, mix evenly, and directly compress the powder into tablets.

Embodiment 2

[0045]

[0046] Preparation Process:

[0047] (1) After camphor is dissolved in star anise oil, it is added in calcium carbonate, stirred and mixed evenly, and placed for 36 hours to obtain adsorbate powder;

[0048] (2) Take licorice extract powder, opium powder, sodium benzoate, acesulfame potassium and powdered sugar by weighing the weight of raw and auxiliary materials in the prescription, grind them into fine powder respectively, cross 120 mesh sieves, and set aside;

[0049](3) Add opium powder, sodium benzoate, sugar powder and acesulfame potassium to the licorice extract powder in equal increments, mix well to obtain a mixture, add the adsorbent powder prepared in (1), and then add talcum powder , Micropowder silica gel, mix evenly, and directly compress the powder into tablets.

Embodiment 3

[0051]

[0052] Preparation Process:

[0053] (1) After camphor is dissolved in star anise oil, it is added in calcium hydrogen phosphate, stirred and mixed evenly, and placed for 24 hours to obtain adsorbate powder;

[0054] (2) Take licorice extract powder, opium powder, sodium benzoate, stevioside and powdered sugar by weighing the weight of raw and auxiliary materials in the prescription, grind them into fine powder respectively, pass through a 120 mesh sieve, and set aside;

[0055] (3) Add opium powder, sodium benzoate, powdered sugar and stevioside to licorice extract powder in an equal increment method, mix well to obtain a mixture, add the prepared adsorbate powder in (1), add talcum powder, micronized silica gel , mixed evenly, and the powder is directly compressed into tablets.

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PUM

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Abstract

The invention relates to a compound liquorice tablet and a preparation process thereof. The compound liquorice tablet comprises the following raw materials: liquorice root extracts, opium powder, camphor, star anise oil, sodium benzoate, an adsorbent and a corrective. The preparation process comprises the following steps: adding the adsorbent in the raw material composition, and hiding special foul smell of the camphor and the star anise oil by adopting an adsorption method to eliminate the foul smell; adding the corrective in the raw material composition to enable the compound liquorice tablet to have satisfactory mouthfeel. Therefore, the compound liquorice tablet prepared by the invention is suitable for being taken orally, excellent in mouthfeel, good in clinical effects, and high in bioavailability. Meanwhile, through the improvement on the process, especially, a manner of performing direct tabletting on powder is adopted, so that the compound liquorice tablet is remarkably improved in process level, stable in quality and stable in effect; the production cost of the product is further reduced, and the tablet can serve patients better.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a compound licorice tablet for buccal administration and a preparation process thereof. Background technique [0002] Compound licorice tablet is a commonly used antitussive and expectorant drug, which is a compound preparation made of active ingredients such as licorice extract powder, opium powder, camphor, star anise oil, and sodium benzoate. The traditional preparation process is as follows: take the licorice extract, dry it, grind it, add sodium benzoate and opium powder to mix evenly, carry out wet granulation, then add camphor and star anise oil dissolved in a small amount of ethanol, mix evenly and press into tablets. At present, there are more than ten domestic manufacturers producing compound licorice tablets, all of which adopt this traditional production process, and the produced compound licorice tablets are all taken orally. However,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K9/20A61K47/02A61K47/20A61K47/26A61K47/22A61P11/14A61P11/10A61K31/125A61K31/192
CPCA61K9/2009A61K9/2018A61K31/125A61K36/484A61K36/57A61K36/66A61K2300/00
Inventor 孙志刚路军贾宁花
Owner 宁夏启元国药有限公司
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