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Compound florfenicol preparation for treating swine respiratory tract infection diseases and preparation method thereof

A technology of florfenicol and flunixin meglumine, which is applied in the field of compound florfenicol preparation and its preparation for the treatment of porcine respiratory diseases, can solve the problems of ignoring inflammatory reactions and fever symptoms, and reduce treatment costs, The effect of relieving the pain of suffering animals and formulating reasonable prescriptions

Inactive Publication Date: 2013-02-13
QINGDAO VLAND BIOTECH INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the treatment of respiratory diseases basically only uses one or more antibiotics to resist infection, ignoring the inflammatory response and fever symptoms accompanying the pathogenesis of respiratory diseases

Method used

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  • Compound florfenicol preparation for treating swine respiratory tract infection diseases and preparation method thereof
  • Compound florfenicol preparation for treating swine respiratory tract infection diseases and preparation method thereof
  • Compound florfenicol preparation for treating swine respiratory tract infection diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Take 480g of N-N-dimethylformamide, add 150g of florfenicol injection raw materials, stir until it is completely dissolved, and set aside; take another 320g of glycerin formal, heat to 50-60°C, add 30g of flunixin meglumine , stir to dissolve, cool to about 30°C, add it to the florfenicol solution to obtain a mixed solution for later use; dissolve 1 g of sodium sulfite in an appropriate amount of water, add it to the mixed reserve solution, and then add 1,2-propanediol To the full volume of 10L; filtered, potted, sterilized at 100°C for 30 minutes, vested.

Embodiment 2

[0075] Take 400g of N-N-dimethylformamide, add 200g of florfenicol injection raw materials, stir until it is completely dissolved, and set aside; take another 150g of glycerin formal, heat to 50-60°C, add 30g of flunixin meglumine , stir to dissolve, cool to about 30°C, add it to the florfenicol solution to obtain a mixed solution for later use; dissolve 1 g of sodium sulfite in an appropriate amount of water, add it to the mixed reserve solution, and then add 1,2-propanediol To the full volume of 10L; filtered, potted, sterilized at 100°C for 30 minutes, vested.

Embodiment 3

[0077] Take 400g of N-N-dimethylformamide, add 200g of florfenicol injection raw material, stir until it is completely dissolved, and set aside; take another 150g of glycerin formal, heat to 50-60°C, add 40g of flunixin meglumine , stir to dissolve, cool to about 30°C, add it to the florfenicol solution to obtain a mixed solution for later use; dissolve 1 g of sodium sulfite in an appropriate amount of water, add it to the mixed reserve solution, and then add 1,2-propanediol To the full volume of 10L; filtered, potted, sterilized at 100°C for 30 minutes, vested.

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Abstract

The invention discloses a compound florfenicol preparation for treating swine respiratory tract infection diseases and a preparation method thereof. The compound florfenicol preparation comprises florfenicol, flunixin meglumine, a composite organic solvent and an antioxidant agent, and the florfenicol and the flunixin meglumine are used as main drugs. The compound florfenicol preparation has anti-infection, anti-inflammation, antipyresis and analgesia effects, is dosed through subcutaneous injection and has remarkable effects for preventing and treating the swine respiratory tract diseases. The compound florfenicol preparation is exquisite in preparing process, controllable in quality, safe, reliable, convenient to use, low in cost, and suitable for being popularized and applied to cultivation industry.

Description

technical field [0001] The invention relates to the technical field of preparation of pharmaceutical preparations, in particular to a compound florfenicol preparation for treating porcine respiratory diseases and a preparation method thereof. Background technique [0002] Porcine respiratory disease is one of the main diseases that endanger the healthy development of the pig industry. The increased mortality caused by the disease, the reduction of animal weight gain, and the cost of prevention and treatment have caused huge economic losses to the pig industry. The pathogenic factors of porcine respiratory diseases are complex, such as multocida, actinomyces pleuropneumoniae, mycoplasma hyopneumoniae, porcine respiratory and reproductive syndrome virus, porcine respiratory coronavirus and other pathogens. In addition, stress reactions occur during the grouping and transfer process, and secondary infections are also prone to cause respiratory diseases. The main symptoms of si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/44A61K31/165A61K9/08A61P11/00A61P31/04A61P29/00
Inventor 郝智慧冯培生贾德强刘元元栾明娜王艳玲沈巍
Owner QINGDAO VLAND BIOTECH INC
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