Pharmaceutical composition containing tea leaf extract and application of pharmaceutical composition in treatment of cancers

A technology of tea extract and composition, which is applied in the field of medicine composition containing tea extract to treat cancer, can solve the problems of not being able to cure lung cancer, blindly exaggerate the therapeutic effect, and dismiss it, so as to achieve the recovery of mental state and physical strength , reduce toxic and side effects, and prolong survival

Inactive Publication Date: 2020-04-21
格律药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to various reasons, some medical staff and patients still have many misunderstandings about the treatment of tumors with traditional Chinese medicine, or dismiss it, or blindly exaggerate its therapeutic effect
At present, Chinese herbal medicine can not achieve the purpose of radically curing lung cancer

Method used

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  • Pharmaceutical composition containing tea leaf extract and application of pharmaceutical composition in treatment of cancers
  • Pharmaceutical composition containing tea leaf extract and application of pharmaceutical composition in treatment of cancers
  • Pharmaceutical composition containing tea leaf extract and application of pharmaceutical composition in treatment of cancers

Examples

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preparation example Construction

[0063] f. Preparation of "EGCG+":

[0064] ⑴Add 3.5 times of deionized hot water (60-70°C) to dissolve the obtained crude ester catechin (with stirring), cool down to room temperature, and filter out the precipitated needle-shaped white crystals (lauric acid) (lauric acid Return to e. tea polyphenolic acid solution to prepare crude ester catechins), continue to cool down to 1-4°C, let stand for 24 hours, crystallize, and vacuum filter to obtain solid crystals;

[0065] (2) Dissolve solid crystals with 5-6 times (w / v) 7% acetic acid at room temperature, recrystallize at 0-4°C, and vacuum filter to obtain crystals;

[0066] (3) Recrystallize once more according to (2), vacuum filter to obtain crystals, and freeze-dry the crystals to obtain white crystals "EGCG+". After HPLC detection, the catechin content is ≧98.5%, including 50.5-59% EGCG (epigallocatechin gallate), plus 22.5-26% ECG (epicatechin gallate), plus 10 -13% of GCG (gallocatechin gallate), plus 6.2-9.5% of EGC (epi...

Embodiment 1

[0099] The preparation example of embodiment 1 " EGCG+ "

[0100] ①Extraction of tea powder: Inactivate 800 kg of fresh summer tea leaves (one bud and three leaves) (equivalent to 200 kg of dry tea leaves), crush them into 20-40 meshes, and add them to continuous countercurrent ultrasonic equipment for extraction. The extraction temperature is 50-60°C; the extraction time is 1 hour; the water consumption is 1200 kg.

[0101] ②Preparation of tea juice: Microfilter the extract (including tea liquid and tea dregs) obtained in ① with a 0.5 μm microporous precision filter, wash with water 0.5-1 times the weight of tea leaves at 40-60 °C; Dalton membrane pore ultrafilter is used for ultrafiltration to remove impurities such as pectin and protein to obtain clear tea juice.

[0102] ③Precipitation and separation of double salt: In the tea juice obtained in ②, add zinc sulfate and calcium chloride double salt with a ratio of 3.5:1 of 5-7% of its weight; adjust its pH to 0.5-0.7M sodiu...

Embodiment 2

[0106] Preparation example of embodiment 2 "EGCG+"

[0107] ①Extraction of tea powder: 800 kg of fresh autumn tea leaves (one bud and three leaves) (equivalent to 200 kg of dry tea leaves) are inactivated, crushed into 20-40 meshes, and added to continuous countercurrent ultrasonic equipment for extraction. The extraction temperature is 50-60°C; the extraction time is 1 hour; the water consumption is 1200 kg.

[0108] ②Preparation of tea juice: Filter the extract (including tea liquid and tea dregs) obtained in ① with a 0.5 μm microporous precision filter, wash with water 0.5-1 times the weight of tea leaves at 40-60°C; Dalton membrane pore ultrafilter is used for ultrafiltration to remove impurities such as pectin and protein to obtain clear tea juice.

[0109] ③Precipitation and separation of double salt: In the tea juice obtained in ②, add zinc sulfate and calcium chloride double salt with a ratio of 3.5:1 of 5-7% of its weight; adjust its pH to 0.5-0.7M sodium bicarbonate...

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Abstract

The invention relates to the field of medicines, in particular to a pharmaceutical composition containing a tea leaf extract and application of the pharmaceutical composition in treatment of cancers.The pharmaceutical composition comprises the tea leaf extract and a taxuschinensis branch and leaf extract, and has the following effects: A. the pharmaceutical composition is effective on tumors andcancers, and especially has significant effects on lung cancer, breast cancer, ovarian cancer, liver cancer, stomach cancer, intestinal cancer and rectal cancer; B, a good effect is achieved on the cardiovascular system; C, special curative effects on diseases of the kidney system are achieved, sexual dysfunction and asthenia are mainly treated, and diseases can be removed and body-building can beachieved after frequent eating; D, effectiveness against Digestive System Diseases is achieved; E, a certain curative effect on respiratory diseases is achieved, the symptoms of emphysema and chronicbronchitis can be relieved, the pain of patients is relieved, and the breathing condition is improved; F. cosmetic effect is achieved, facial pigmentation can be eliminated, the skin is compact, theblood color is increased, and the skin is whitened and thinned; and G, a good curative effect is achieved on cure of the traumatology department, chilblain and haemorrhoids.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition containing tea extract and its application for treating cancer. Background technique [0002] Not long ago, the National Cancer Center released the latest national cancer statistics. This data comes from the malignant tumor registration data collected by the National Cancer Registration Center in 2017 from the tumor registries of 31 provinces, municipalities and autonomous regions. Incidence rate: The number of new cases of malignant tumors in the country is 3.804 million, which is equivalent to an average of more than 10,000 people being diagnosed with cancer every day, and 7 people are diagnosed with cancer every minute. [0003] Lung cancer is one of the malignant tumors with the fastest increasing morbidity and mortality and the greatest threat to the health and life of the population. In the past 50 years, many countries have reported that the morbidity...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K36/13A61K31/353A61K36/718A61K36/748A61K36/539A61K36/288A61K36/232A61K36/8984A61K36/481A61K36/284A61K36/076A61K36/484A61K36/704A61K36/39A61K36/43A61K36/46A61K36/638A61K36/537A61K36/9066A61K36/896A61K36/78A61K35/648A61K35/646A61P35/00A61P9/00A61P25/00A61P13/12A61P1/00A61P11/00A61P19/00A61P17/00
CPCA61K31/353A61K35/646A61K35/648A61K36/076A61K36/13A61K36/232A61K36/284A61K36/288A61K36/39A61K36/43A61K36/46A61K36/481A61K36/484A61K36/537A61K36/539A61K36/638A61K36/704A61K36/718A61K36/748A61K36/78A61K36/82A61K36/896A61K36/8984A61K36/9066A61K2236/331A61K2236/51A61P1/00A61P9/00A61P11/00A61P13/12A61P17/00A61P19/00A61P25/00A61P35/00A61K2300/00
Inventor 刘志炯
Owner 格律药业有限公司
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