Nucleic acid drug delivery system and preparation method thereof

A delivery system and nucleic acid technology, which is applied in drug combinations, pharmaceutical formulations, antineoplastic drugs, etc., can solve the problems of low delivery efficiency, need to improve delivery efficiency, and affect the therapeutic effect of nucleic acid drug preparations, so as to improve curative effect and stabilize drug delivery efficiency effect

Inactive Publication Date: 2019-08-23
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, the existing lipid-based non-viral carriers (for example, cationic liposomes) still need to be improved in the delivery efficiency of nucleic acid drugs
The main factors leading to low delivery efficiency include poor stability after carrier and drug compounding, low drug encapsulation efficiency and low targeted drug release efficiency, which also directly affect the therapeutic effect of nucleic acid drug preparations based on nucleic acid drug delivery systems

Method used

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  • Nucleic acid drug delivery system and preparation method thereof
  • Nucleic acid drug delivery system and preparation method thereof
  • Nucleic acid drug delivery system and preparation method thereof

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Embodiment Construction

[0037] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. The examples are only used to explain the present invention, not to limit the protection scope of the present invention.

[0038] The nucleic acid drug delivery system prepared in the present invention, its working principle is as follows: figure 1 shown. The nucleic acid drug delivery system is a pH-sensitive cationic liposome-nucleic acid drug (for example, DNA) complex, and the function of the pH-sensitive cationic liposome is to effectively transport the nucleic acid drug into the target cell and release it in the target cell. It is released under a specific pH environment to make nucleic acid drugs play a role.

[0039] The present invention screens the carrier material and ratio of the cationic liposome according to the characteristics of stability and pH sensitivity, and aims to find a feasible way to improve the delivery efficiency of ...

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Abstract

The invention discloses a nucleic acid drug delivery system and a preparation method thereof. A pH-sensitive cationic liposome capable of wrapping or loading a nucleic acid drug is prepared by screening lipid components and proportions. The prepared cationic liposome is uniform in particle size, high in drug encapsulation efficiency, stable in system and capable of improving the targeted deliveryefficiency of the nucleic acid drug.

Description

technical field [0001] The invention belongs to the field of drug delivery systems, and relates to a nucleic acid drug delivery system based on a non-viral carrier, in particular to the preparation of a lipid non-viral carrier and a nucleic acid drug-lipid non-viral carrier complex. Background technique [0002] Nucleic acid drugs are a variety of ribonucleotides (RNA) or deoxyribonucleotides (DNA) with different functions, mainly at the gene level. It is generally believed that nucleic acid drugs include Aptamer, Antigene, Ribozyme, Antisense Nucleic Acid, and RNA interference agents. Nucleic acid drugs specifically target disease-causing genes, that is to say, they have specific targets and mechanisms of action, so they have broad application prospects. [0003] In order to achieve therapeutic effects, nucleic acid drugs generally have to enter the interior of target cells to play a role, and nucleic acid molecules will be degraded by the body soon after entering the body...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/18A61K47/24A61K47/28A61K47/12A61K47/02A61K48/00A61K31/7105A61P35/00
CPCA61K9/1277A61K31/7105A61K47/02A61K47/12A61K47/186A61K47/24A61K47/28A61K48/005A61P35/00
Inventor 李旭甄帅王翔曹鹏赵乐芦娇娇拓晓倩张燕
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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