39results about How to "Prolong metabolic time" patented technology

The invention provides a preparation method of porous nano-hydroxyapatite sustained-release gel. Hydroxyapatite composite microspheres prepared by the method provided by the invention have uniform size distribution, a particle size distribution range of 10-100 mu m, and a central particle size of 20-60 mu m. Increase of an organic phase in a mixing process can effectively enhance the suspension stability of a suspension; the prepared microspheres have uniform size distribution and a larger particle size than the microspheres prepared by a traditional spray-drying method, and can be used as aninternal support material of injections; and the microspheres have a good spherical shape and high porosity, can enhance the injectability of a material, help to accelerate the metabolism time of drugs, maintain a stable and effective drug concentration in the body, and have good drug-release properties.

A liposome composition used to prepare the medicines for treating tumor, cardiovascular and cerebrovascular disease, altitude ischemia and insomnia is prepared from the mixture of aspirin, prostaglandin E1, antioxidant, 2-hydroxypropyl-beta-dextrin and gamma-dextrin, the mixture of hydrogenated soybean lecithin and yolk lecithin, and the mixture of soybean sterol, polyethanediol-2000, VC and glycine. Its preparing process is also disclosed.

The invention discloses a compound nano-preparation for treating T-cell acute lymphoblastic leukemia and its preparation method and application. Alcohol composition. The steps are: (1) dissolving polylactic acid-polyglycolic acid polymer, IRAK1 / 4 inhibitor and ABT-737 in acetonitrile solution to obtain a mixed solution; (2) emulsifying the mixed solution in polyvinyl alcohol solution to form The emulsion was emulsified on an ice bath using a micro-probe sonicator to obtain an emulsion; (3) the emulsion was stirred at room temperature to obtain inhibitors and compound nanoparticles; (4) the compound nanoparticles were ultracentrifuged in an ultracentrifuge and used Washed with distilled water, freeze-dried and stored to obtain inhibitors and nanoparticles. It also relates to the application of compound nano preparations. The formula is reasonable, the use is convenient, and the metabolism time of the drug is prolonged; the absorption of the drug in tumor cells is increased, thereby further enhancing the synergistic effect of the drug.

The invention discloses a canine interferon alpha particle compound CaIFN alpha-NPa and a preparation method thereof. The compound comprises a gamma-polyglutamic acid-phenylalanine shell and canine interferon alpha wrapped in the shell and is formed by assembling the gamma-polyglutamic acid-phenylalanine shell and the canine interferon alpha through a self-polymerization process. The invention also discloses application of the canine interferon alpha particle compound in the preparation of canine antiviral drugs and an antiviral composition. The canine interferon alpha particle compound is high in wrapping rate, free of toxic and side effects and good in biocompatibility, can be used for retarding enzymatic degradation to realize the drug effect slow-release effect, is simple and easy to operate, low in cost and suitable for large-scale production, and has favorable application prospect.

The invention discloses a berberrubine and baicalein compound with the structure shown in the general formula (I). The invention further discloses a preparing method of the compound, and the compound is formed by synthesizing berberrubine and baicalein. The invention furthermore discloses application of the compound to preparation of a drug for treating ulcerative enteritis. Compared with berberrubine and baicalein, toxicity of the polynuclear molecular compound is reduced substantially, absorption is improved substantially, bioavailability is improved, the metabolism time is prolonged, the long-acting effect can be achieved, and the pharmacological effects of resisting ulcerative enteritis and pathogenic bacteria are enhanced.

The invention discloses a tanshinone IIA-polyactic acid / hydroxyacetic acid microsphere and a preparation method thereof. The microsphere is prepared by drying oil-in-water type emulsion, wherein the oil phase is dichloromethane solution of a polyactic acid / hydroxyacetic acid copolymer and the water phase is the water solution of polyvinyl alcohol. The drug content of tanshinone IIA in the microsphere is 1-10% and the entrapment efficiency is 60-90%. The particle size range of the microsphere is 30-200mm. The tanshinone IIA-polyactic acid / hydroxyacetic acid microsphere provided by the invention is suitable for interventional therapy of liver cancers, has a good liver tumor peripheral vascular thrombosis function, has an effective thrombosis time of 7-60 days, can be distributed in tumor tissues in a targeted manner, slowly release drugs, increase the local concentrations of the drugs, prolong the drug metabolism time, obviously inhibit animal liver tumor growth and prolong the animal lifetime and can inhibit expressions of a human hypoxia inducible factor 1alpha and a vascular endothelial growth factor and reduce the tumor tissue microvessel density after thrombosis.

The present invention relates to the controllable degradation, filling-type complex bone implant of multivariant amino acid polymer-organic calcium / phosphorus salts, as well as to the preparative method thereof. The complex bone implant is consisted of multivariant amino acid polymers and medically acceptable organic calcium / phosphorus salts, while the content of organic calcium / phosphorus salts is 20-90% based on the total mass of composite material; the multivariant amino acid polymer is polymerized by ε-aminocaproic acid and at least two other amino acids, in which the molar content of ε-aminocaproic acid is at least 50% of the total molar quantity of amino acid polymers, while the amounts of other amino acids are at least 0.5% of the total molar quantity of amino acid polymers.

The invention discloses a high-surface-tension hydrogel vitreous substitute and a radiation preparation method thereof. The preparation method comprises the following steps: performing ultrasonic stirring on natural polysaccharides, supermolecules, a radiation sensitizer, a pH adjuster and a solvent which serve as main components to prepare a uniform dispersion system, feeding N2 for stewing and debubbling at negative pressure, performing vacuum encapsulation and quick circulating freezing-defreezing, and performing radiation crosslinking reaction on the dispersion system with the natural polysaccharides and the supermolecules, which serve as base materials, under ionizing radiation to prepare the high-surface-tension hydrogel vitreous substitute. The product is emulsification-free and dispersion-free, is higher in surface tension, can be self-degraded and absorbed slowly, is relatively long in metabolic time, can up press irregular surfaces and effectively close a retinal hole, is not liable to enter a retina, and has the characteristics of high light transparency, viscoelasticity, shock absorption property, uniformity, biological compatibility, safety and the like; preparation, plasticization, sterilization and the like can be synchronously completed, and a production process is simplified.

The invention discloses a mutation gene m2TFPI of human gene inhibitor factor with restructuring carrier and restructuring yeast, which possesses sequence as SEQ ID No.1, wherein the restructuring carrier connects m2TFPI DNA and pPIC9 carrier in the T4 connecting enzyme through digest segment of XhoI and EcoRI to form m2TFPI-pPIC9.

The invention discloses a preparation method of gossypol acetate calcium alginate gel microspheres. Gossypol acetate is dissolved into N,N-dimethyl acetamide; epsilon-polylysine, diclofenac potassiumand potassium chloride are dissolved into water; the solution is uniformly mixed to obtain a stock solution; calcium chloride is dissolved into water; sodium alginate is dissolved into water to be prepared into a solution with the mass concentration being 1 to 2 percent; the stock solution is added into the sodium alginate solution; stirring is performed till the uniform mixing; a micro quantity injection pump is used for dripping the solution into the calcium chloride solution; gelatinization is performed for 20 to 40min to obtain microspheres. A buffer solution is used for flushing the microspheres to obtain the gossypol acetate calcium alginate gel microspheres. The gossypol acetate calcium alginate gel microspheres have the advantages of high embedding rate, good swelling property andgood medicine release property.