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Composition of liposome, and preparation method

A technology of composition and plastid, which is applied in the field of liposome composition and its preparation, can solve problems such as serious adverse drug reactions, achieve the effects of reducing drug dosage, enhancing targeting, and reducing costs

Inactive Publication Date: 2007-02-21
江苏仲德医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage of aspirin and alprostadil is still too large, so that the adverse drug reactions are still serious

Method used

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  • Composition of liposome, and preparation method
  • Composition of liposome, and preparation method
  • Composition of liposome, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The formula that present embodiment adopts is as follows:

[0035] Aspirin 20000g;

[0036] Alprostadil 1g;

[0037] Antioxidant 1000g;

[0038] The mixture of 2-hydroxypropyl-β-cyclodextrin and γ-cyclodextrin 2000g;

[0039] Hydrogenated soybean lecithin and egg yolk lecithin 1: 2 weight ratio mixture 6000g;

[0040] Soy sterol 3000g;

[0041] Polyethylene glycol-2000 2000g;

[0042] Vitamin C and glycine weight ratio 3: 1 mixture 4000g.

[0043] The antioxidant is a mixture of vitamin E and gamma-linolenic acid or dihomo-gamma-linolenic acid in any weight ratio. Wherein the aspirin may be aspirin lysine, aspirin arginine, and its weight is calculated by aspirin.

[0044] The preparation method steps are as follows:

[0045] (1) dissolving the phospholipid mixture, soy sterol, and antioxidant of formula quantity into solution with dehydrated alcohol or ether;

[0046] (2) Put the solution prepared in step (1) in a rotary evaporator, and evaporate to dryness at...

Embodiment 2

[0088] The formula adopted in this embodiment:

[0089] Aspirin 3500mg;

[0090] Alprostadil 350mg;

[0091] Antioxidant 180g;

[0092] Mixture of 2-hydroxypropyl-β-cyclodextrin and γ-cyclodextrin 250g;

[0093] Hydrogenated soybean lecithin and egg yolk lecithin 1: 3 weight ratio mixture 900g;

[0094] Soy sterol 600g;

[0095] Polyethylene glycol-2000 420g;

[0096] Vitamin C and glycine weight ratio 3: 1 mixture 560g.

[0097] The antioxidant is a mixture of vitamin E and gamma-linolenic acid or dihomo-gamma-linolenic acid in any weight ratio. γ-linolenic acid is also known as vitamin F. Dihomo-γ-linolenic acid is also called arachitrienoic acid.

[0098] Wherein the aspirin may be aspirin lysine, aspirin arginine, and its weight is calculated by aspirin.

[0099] The present invention also provides the preparation method of described aspirin and alprostadil liposome composition, and the steps are as follows:

[0100] (1) dissolving the phospholipid mixture, soy s...

Embodiment 3

[0144] The formula that present embodiment adopts is as follows:

[0145] Aspirin 20000g;

[0146] Alprostadil 5g;

[0147] Antioxidant 1000g;

[0148] The mixture of 2-hydroxypropyl-β-cyclodextrin and γ-cyclodextrin 3000g;

[0149] Hydrogenated soybean lecithin and egg yolk lecithin 1: 4 weight ratio mixture 6000g;

[0150] Soy sterol 8000g;

[0151] Polyethylene glycol-2000 2000g;

[0152] Vitamin C and glycine weight ratio 3: 1 mixture 6000g.

[0153] The antioxidant is a mixture of vitamin E and gamma-linolenic acid or dihomo-gamma-linolenic acid in any weight ratio. Wherein the aspirin may be aspirin lysine, aspirin arginine, and its weight is calculated by aspirin.

[0154] The preparation method steps are as follows:

[0155] (1) dissolving the phospholipid mixture, soy sterol, and antioxidant of formula quantity into solution with dehydrated alcohol or ether;

[0156] (2) Put the solution prepared in step (1) in a rotary evaporator, and evaporate to dryness at...

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Abstract

A liposome composition used to prepare the medicines for treating tumor, cardiovascular and cerebrovascular disease, altitude ischemia and insomnia is prepared from the mixture of aspirin, prostaglandin E1, antioxidant, 2-hydroxypropyl-beta-dextrin and gamma-dextrin, the mixture of hydrogenated soybean lecithin and yolk lecithin, and the mixture of soybean sterol, polyethanediol-2000, VC and glycine. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a liposome composition and a preparation method thereof. Background technique [0002] Existing aspirin preparation single or compound medicines are all limited to anti-inflammatory and analgesic, and are used to treat cardiovascular and cerebrovascular diseases. The present invention finds that aspirin also has curative effects of resisting metastasis of cancer cells, improving microcirculation, advanced cancer and analgesia. [0003] The scope of treatment of existing alprostadil single prescription and compound preparation is also mainly limited to the treatment of cardiovascular and cerebrovascular diseases. The present invention finds that, in fact, alprostadil also has the effect of inhibiting tumor cells and differentiated tumor cells from developing to normal cells, and also has anti-tumor and anti-tumor effects. The effect of cancer cell metastasis can also improve microcirculation, regulate human immune function, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/616A61K31/5575A61P35/00A61P9/00A61P25/20
Inventor 蔡海德
Owner 江苏仲德医药科技有限公司
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