Preparation method for improving liposome entrapment efficiency

A body encapsulation rate, lipid technology, applied in the field of medicine, can solve the problems of difficult to increase the encapsulation rate of lipid-water insoluble compounds, large toxic and side effects, etc., to improve solubility and bioavailability, eliminate side effects, and improve drug stability sexual effect
CN101874780AActive Publication Date: 2010-11-03SHENYANG PHARMA UNIVERSITY +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2010-11-03

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Abstract

The invention aims to provide a preparation method for improving liposome entrapment efficiency. The preparation method comprises the following steps: dissolving liposoluble components in an organic solvent, and dissolving water-soluble components in alkalescent or acidulous buffer salt; transferring the organic solvent, and adding buffer salt solution for hydration; and after vacuum freeze drying, redissolving the components in the alkalescent or acidulous buffer salt, and incubating to obtain a medicament-containing liposome. Acid compounds are easily dissolved in alkaline solution, and alkaline compounds are easily dissolved in acid solution; and in the method, the liposome is prepared by utilizing the characteristic of solubility change due to the acid-base difference, so that the entrapment efficiency of the compounds in the liposome is improved greatly, and a novel idea for preparing the liposome for indissoluble compounds is provided.
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Description

technical field

[0001] The invention belongs to the technical field of medicine and relates to a preparation method for improving liposome encapsulation efficiency. Background technique

[0002] The improvement of in vivo bioavailability of poorly soluble compounds has always been a research hotspot in pharmacy. However, many poorly soluble compounds are not only insoluble in water, but also insoluble in physiological tolerance and solvents commonly used in pharmacy, that is, lipid-water insolubility, which hinders the design and application of dosage forms.

[0003] When the liposome is delivered to the tumor blood vessels, it can enter the tumor tissue through the capillary epithelial tissue gap, so as to achieve a certain tumor tissue targeting effect. The passive targeting of the liposome drug delivery system, because it changes the distribution of the drug in the body, can improve the curative effect and reduce toxicity at the same time, and it is a good carrier for in...

Claims

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