Non-toxic cross-linked sodium hyaluronate gel articular cavity injection and preparation method thereof
A technology of sodium hyaluronate and articular cavity, which is applied in the direction of pharmaceutical formula, aerosol delivery, medical preparations of non-active ingredients, etc. It can solve problems such as toxicity, reduce toxicity, reduce the probability of adverse reactions, and have a stable structure Effect
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[0040] This example describes the preparation process of the cross-linking reaction between sodium hyaluronate and L-lysine, and detects the shear viscosity of the product.
[0041]Add 100 mL of phosphate buffer solution and 2 g of sodium hyaluronate raw material into a 500 mL round bottom flask, stir overnight at room temperature to dissolve. Add 1g of L-lysine into the reaction system, stir at 2-8°C for 2h, add 1g of DMTMM to catalyze the cross-linking reaction, and stir at 2-8°C for 24h to carry out the cross-linking reaction. Add ethanol to the obtained reaction product to precipitate and collect, and use ethanol to wash the obtained precipitate 3 times for 10 minutes each time, until the precipitate completely loses water, put the precipitate in a vacuum dryer and dry it for 24 hours to obtain a slightly cross-linked glass Sodium acid gel dry powder. Use phosphate buffer solution to redissolve the dry powder, add the dry powder to the phosphate buffer solution and dissol...
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