Magnetic hydrogel device and preparation method and application thereof

A hydrogel and device technology, applied in the field of magnetic hydrogel devices, can solve the problems of easy diffusion of magnetic nanoparticles, affecting therapeutic effects, and easy metabolism.

Active Publication Date: 2021-07-06
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Purpose of the invention: The present invention provides a magnetic hydrogel device for the problem that the magnetic nanoparticles existing in the process of neuromodulation using magnetic nanoparticles in the prior art are easy to diffuse and easy to metabolize in the living body and thus affect the therapeutic effect.

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  • Magnetic hydrogel device and preparation method and application thereof
  • Magnetic hydrogel device and preparation method and application thereof
  • Magnetic hydrogel device and preparation method and application thereof

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Embodiment 1

[0028] The preparation method of the magnetic hydrogel device of the present invention comprises the following steps:

[0029] (1) Preparing the precursor solution: adding sodium alginate to water, vigorously stirring and dissolving at room temperature to form a mother solution with a mass fraction of 2.5%; Element mass meter) magnetic nanoparticle solution mixed, and add deionized water to the mixed solution and stir vigorously to prepare a precursor solution; in the precursor solution, the mass fraction of sodium alginate is 2%, and the concentration of magnetic nanoparticles is 1mg / mL ;

[0030] (2) Preparation of receiving solution: adding absolute ethanol to the calcium chloride solution with a mass fraction of 2% to form a receiving solution; wherein, the mixing volume ratio of calcium chloride solution and absolute ethanol is 2:1;

[0031] (3) Preparation of magnetic hydrogel devices: Pour 10mL of receiving solution into a petri dish, and fix the microfluidic chip with...

Embodiment 2

[0034] The preparation method of the magnetic hydrogel device of the present invention comprises the following steps:

[0035] (1) Preparing the precursor solution: adding sodium alginate into water, vigorously stirring and dissolving at room temperature to form a mother solution with a mass fraction of 4%; iron element mass meter) magnetic nanoparticle solution mixed, and in the mixed solution, add deionized water and vigorously stir to prepare a precursor solution; in the precursor solution, the mass fraction of sodium alginate is 1.8%, and the concentration of magnetic nanoparticles is 1mg / mL;

[0036] (2) Prepare the receiving solution: add absolute ethanol to the calcium chloride solution with a mass fraction of 2% to form a receiving solution; wherein, the mixing volume ratio of the calcium chloride solution and absolute ethanol is 3:1;

[0037] (3) Preparation of magnetic hydrogel devices: Pour 10mL of receiving solution into a petri dish, and fix the microfluidic chi...

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Abstract

The invention discloses a magnetic hydrogel device. According to the magnetic hydrogel device, hydrogel is used as a main body structure, and a plurality of magnetic nanoparticles are filled in the hydrogel. The invention further discloses a preparation method of the magnetic hydrogel device and application of the magnetic hydrogel device in nerve magnetic stimulation. Compared with a single magnetic nanoparticle, the magnetic hydrogel device has stronger superparamagnetism, is not easy to diffuse and metabolize in a living body (the metabolism time of a magnetic material in the living body is prolonged), the problem that the single magnetic nanoparticle is easy to diffuse and metabolize in the living body can be solved, the magnetic effect time of the magnetic nano-particles in the living body is further prolonged, damage caused by frequent injection of nano-drugs in nerve regulation and control is reduced, the magnetic nano-particles can exert the electromagnetic effect and the force effect at the same time, and then the ion channel activation capacity of nerve cells is cooperatively improved.

Description

technical field [0001] The present invention relates to a magnetic hydrogel device, and also relates to a preparation method of the magnetic hydrogel device and its application in nerve magnetic stimulation. Background technique [0002] In recent years, magnetic nanoparticles have been widely used in the field of biomedicine. Magnetic nanoparticles can produce a unique biomagnetic effect under the action of a magnetic field, which has been used in biomedical fields such as neuromodulation, tumor targeting imaging, and tumor treatment. At present, it has been reported that the injection of magnetic iron oxide nanoparticles into specific nerve nuclei combined with the action of an external magnetic field can be used for neuromodulation, but magnetic nanoparticles are easy to diffuse and metabolize in vivo, which affects the accuracy and timeliness of treatment, and repeated administration This in turn presents a risk of trauma and infection. Contents of the invention [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/06A61K47/36A61N2/10B82Y5/00
CPCA61K41/00A61K9/06A61K47/36B82Y5/00A61N2/06
Inventor 孙剑飞薛乐王鹏张志珺蒋青顾宁
Owner SOUTHEAST UNIV
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