A kind of photomagnetic thermosensitive nano-composite drug carrier and preparation method thereof

A nano-composite and nano-composite technology, applied in pharmaceutical formulations, drug combinations, anti-tumor drugs, etc., can solve the problems of deterioration of the patient's immune system, uneven properties of the complex, and difficulty in industrialization, achieving a controllable and repeatable size. The effect of good sex and simple method

Inactive Publication Date: 2019-04-09
JILIN NORMAL UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] A common problem in the current cancer treatment process is that oral or injected anticancer drugs are administered systemically, and the drugs will not only act on cancer cells, but also on healthy cells, causing the patient's immune system to further deteriorate
In addition, the steps of the existing preparation method are difficult to control, the properties of the prepared compound are not uniform, and it is difficult to realize industrialization

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of photomagnetic thermosensitive nano-composite drug carrier and preparation method thereof
  • A kind of photomagnetic thermosensitive nano-composite drug carrier and preparation method thereof
  • A kind of photomagnetic thermosensitive nano-composite drug carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] (1) Solvothermal preparation of zinc sulfide doped manganese quantum dots: Weigh 0.8561g Zn(CH 3 COO) 2 2H 2 O and 0.0097gMn(CH 3 COO) 2 4H 2 O, it was poured into a 250ml beaker with 7ml deionized water, and stirred magnetically for 10min until dissolved. Then, 9.75ml of oleic acid, 1.3g of sodium oleate, and 16ml of ethanol were sequentially added to the above solution, and magnetically stirred for 1 hour to form emulsion A. 0.937g Na 2 S·9H 2 O was poured into a 250ml beaker containing 7ml deionized water, and stirred magnetically for 10min until dissolved to obtain an aqueous solution of sodium sulfide. Add aqueous sodium sulfide solution to emulsion A, and stir magnetically for 2 hours to obtain solution B, transfer solution B to a 50ml reaction kettle, put the reaction kettle into a drying oven, and set the temperature of the drying oven to 190°C, and react for 12 hours . The product obtained by the reaction was centrifuged and washed three times with a s...

Embodiment 2

[0056]Embodiment 1 is the preferred mode of the present invention. In addition to the method steps described in Embodiment 1, the amount of raw materials added and the reaction conditions are slightly changed. With reference to existing methods and analysis based on reaction principles, it is disclosed in the content of the invention The change of the reaction conditions can not cause the substantive change of the method of the present invention, and the present invention can be realized. For example: in Example 1 of the present invention, when using oleic acid to modify the surface of ferric oxide, oleic acid with a volume of 15% to 50% of deionized water can be added, and the reaction is carried out at 20 to 60°C for 1 to 6 hours That's it. The specific steps of coating silicon dioxide can refer to the prior art. During further hydroxylation treatment, the surface silicon dioxide can be hydroxylated by heating at 75-85° C. for 1-2 hours under the condition of pH=3-5. When h...

Embodiment 3

[0058] Structural and functional characterization

[0059] The present invention characterizes the target product from structure and function respectively, and characterizes the structure of the target product by means of transmission electron microscopy, as shown in figure 1 As shown, the black area is ZnS:Mn 2+ Quantum dots or Fe 3 o 4 Quantum dots, the dark gray areas on the surface are SiO coated on the surface 2 , the outermost light gray area is PNIPAAm.

[0060] The functional characterization of the present invention is divided into temperature-sensitive characteristic characterization, magnetic characterization and luminescence characteristic characterization.

[0061] The invention characterizes its temperature-sensitive characteristics through the curve of light transmittance versus temperature. Such as figure 2 As shown, the phase transition temperature of the target product is 41.1°C, which is higher than the body temperature of the human body, which is 37°...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a photo-magnetic and temperature-sensitive nano-composite drug carrier and a preparation method thereof, belongs to the field of drug carriers, and provides a preparation method to solve the problems that the prior art is relatively poor in fluorescence, magnetic property and thermosensitivity in preparation of the photo-magnetic and temperature-sensitive nano-composite drug carrier, and the preparation steps are adverse to industrial production. The method comprises the following steps: with n-isopropylacrylamide, tetraethoxysilane, ZnS:Mn<2+> quantum dots and Fe3O4 quantum dots as main raw materials, firstly, carrying out surface modification on the Fe3O4 quantum dots by oleinic acid; secondly, simultaneously embedding the ZnS:Mn<2+> quantum dots and the Fe3O4 quantum dots into SiO2; thirdly, modifying double bonds on the SiO2 surface by a silane coupling agent; and finally coating a polymer PNIPAAm through free radical polymerization, and achieving preparation of ZnS:Mn<2+> quantum dots / Fe3O4 quantum dots / SiO2 / PNIPAAm of the photo-magnetic and temperature-sensitive nano-composite drug carrier.

Description

technical field [0001] The invention belongs to the field of drug carriers, and in particular relates to a luminescent, magnetic and temperature-sensitive composite drug carrier material and a preparation method thereof. Background technique [0002] A common problem in the current cancer treatment process is that oral or injected anticancer drugs are administered systemically, and the drugs will not only act on cancer cells, but also on healthy cells, causing the patient's immune system to further deteriorate. Therefore, there is an urgent need to design new non-toxic nanocomposite drug carriers that allow drugs to specifically target cancer cells without damaging surrounding healthy cells, thereby improving the efficiency of cancer treatment and greatly reducing damage to the human body. [0003] The temperature-sensitive polymer PNIPAAm (polyisopropylacrylamide) has good biocompatibility, biodegradability, and temperature switching characteristics, and has a simple prepar...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K47/04A61K47/02A61K47/24A61P35/00
CPCA61K47/02A61K47/24A61K47/32
Inventor 曹健牛海凤杨景海
Owner JILIN NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap