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A kind of magnetic hydrogel device and its preparation method and application

A hydrogel and device technology, applied in the field of magnetic hydrogel devices, can solve the problems of easy diffusion of magnetic nanoparticles, affect the therapeutic effect, and easy metabolism, and achieve the effects of improving activation ability, difficult diffusion, and long metabolic cycle.

Active Publication Date: 2022-07-29
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Purpose of the invention: The present invention provides a magnetic hydrogel device for the problem that the magnetic nanoparticles existing in the process of neuromodulation using magnetic nanoparticles in the prior art are easy to diffuse and easy to metabolize in the living body and thus affect the therapeutic effect.

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  • A kind of magnetic hydrogel device and its preparation method and application
  • A kind of magnetic hydrogel device and its preparation method and application
  • A kind of magnetic hydrogel device and its preparation method and application

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Embodiment 1

[0028] The preparation method of the magnetic hydrogel device of the present invention comprises the following steps:

[0029] (1) Preparation of precursor solution: add sodium alginate to water, stir and dissolve vigorously at room temperature to form a mother solution with a mass fraction of 2.5%; the concentration of the mother solution (sodium alginate solution) and magnetic nanoparticles is 23 mg / mL (by iron Elemental mass meter) magnetic nanoparticle solution, and add deionized water to the mixture and stir vigorously to prepare a precursor solution; in the precursor solution, the mass fraction of sodium alginate is 2%, and the concentration of magnetic nanoparticles is 1mg / mL. ;

[0030] (2) preparing the receiving solution: adding absolute ethanol to the calcium chloride solution whose mass fraction is 2% to form the receiving solution; wherein, the mixed volume ratio of the calcium chloride solution and the absolute ethanol is 2:1;

[0031] (3) Preparation of magneti...

Embodiment 2

[0034] The preparation method of the magnetic hydrogel device of the present invention comprises the following steps:

[0035] (1) Preparation of precursor solution: add sodium alginate to water, stir and dissolve vigorously at room temperature to form a mother liquor with a mass fraction of 4%; the concentration of the mother liquor (sodium alginate solution) and magnetic nanoparticles is 23.5 mg / mL (pressing The magnetic nanoparticle solution of iron element mass meter) was mixed, and deionized water was added to the mixed solution and vigorously stirred to prepare a precursor solution; in the precursor solution, the mass fraction of sodium alginate was 1.8%, and the concentration of magnetic nanoparticles was 1mg / mL;

[0036] (2) preparing the receiving solution: adding absolute ethanol to the calcium chloride solution whose mass fraction is 2% to form the receiving solution; wherein, the mixing volume ratio of the calcium chloride solution and the absolute ethanol is 3:1;...

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Abstract

The invention discloses a magnetic hydrogel device. The hydrogel device takes a hydrogel as a main structure, and a plurality of magnetic nanoparticles are arranged in the hydrogel. The invention also discloses the preparation method of the above magnetic hydrogel device and its application in nerve magnetic stimulation. Compared with the single magnetic nanoparticle, the magnetic hydrogel device of the present invention has stronger superparamagnetic properties, and at the same time, it is not easy to diffuse and metabolize in the living body (extending the metabolism time of the magnetic material in the living body), and can overcome the single magnetic nanoparticle. The problem that particles are easy to diffuse and metabolize in vivo further improves the biomagnetic effect time of magnetic nanoparticles in vivo, reduces the damage caused by frequent injection of nanomedicine in neuromodulation, and at the same time exerts electromagnetic effect, It can also exert a force effect, thereby synergistically improving the ion channel activation ability of nerve cells.

Description

technical field [0001] The invention relates to a magnetic hydrogel device, and also relates to a preparation method of the above-mentioned magnetic hydrogel device and its application in nerve magnetic stimulation. Background technique [0002] In recent years, magnetic nanoparticles have been widely used in the field of biomedicine. Magnetic nanoparticles can produce unique biomagnetic effects under the action of magnetic fields, which have been used in biomedical fields such as neuromodulation, tumor targeting imaging, and tumor therapy. At present, it has been reported that magnetic iron oxide nanoparticles are injected into specific nerve nuclei combined with external magnetic field for neural regulation. However, magnetic nanoparticles are easy to diffuse and metabolize in vivo, which affects the precision and timeliness of treatment. Repeated administration There is also the risk of trauma and infection. SUMMARY OF THE INVENTION [0003] Purpose of the invention: ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K41/00A61K47/36A61N2/10B82Y5/00
CPCA61K41/00A61K9/06A61K47/36B82Y5/00A61N2/06
Inventor 孙剑飞薛乐王鹏张志珺蒋青顾宁
Owner SOUTHEAST UNIV
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