A physiological poison metabolism kinetic model for adults exposed to bisphenol A through mouths

Abstract

The invention relates to the field of public health, particularly relates to chemical risk assessment, and especially relates to a physiological poison metabolism kinetic model for adults exposed to bisphenol A through mouths. The construction method of the model comprises the following steps: S1, determining a kinetic process of absorption, distribution, metabolism and excretion of the bisphenolA orally taken in a human body; S2, determining a physiological poison metabolism kinetic model structure of the adults exposed to bisphenol A through the mouths; S3, establishing a mathematical model, and compiling a differential equation; S4, acquiring human physiological parameters, bisphenol A biochemical parameters and bisphenol A toxicokinetic parameters; and S5, carrying out simulation andparameter optimization on the physiological poison metabolism kinetic model of the bisphenol A. The model and the method disclosed by the invention are helpful to establish bisphenol A internal and external exposure association of the human body, simulate the content level of bisphenol A in a target organ, and further clarify an effect mechanism and a dose-reaction relationship of the bisphenol Ain combination with an effect index of the bisphenol A, so that the health risk that people are exposed to bisphenol A through the mouths can be evaluated more accurately, and important scientific basic data are provided for making and correcting bisphenol A limit values.

Description

technical field [0001] The invention relates to the field of public health, in particular to chemical risk assessment. In particular, it relates to a physiological toxicokinetic model of adult oral exposure to bisphenol A. Background technique [0002] Bisphenol A (bisphenol A, BPA) (2,2-bis(4-hydroxyphenyl)propane, CAS No. 80-05-7, is a chemical, mainly used in the production of polycarbonate plastics and epoxy Resin monomer, also used in polyester resin, polysulfone resin and polyacrylate resin and flame retardant.Food contact materials, such as baby bottles, tableware, microwave ovens, ovens, food containers, water bottles, milk and beverage bottles, food Polycarbonate is widely used in processing equipment and water pipes, etc. Epoxy resins are used as protective linings in various canned food and beverages, as well as glass jars and bottles, including coatings on metal lids for infant formula containers. Food packaging and BPA added in contact materials will migrate t...

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Problems solved by technology

[0008] Chemicals and their metabolites often show specific toxic effects on biological targets such as specific cells, tissues or organs. Therefore, it is necessary to obtain the "target concentration" of the above-mentioned sites, and it is difficult to affect the internal organs of the human body only by experimental means. or tissue separation and extraction, and because human experiments are too complicated, it is usually necessary to extrapolate based on experimental data of other species (such as rodents), but the differences in physiological structure and function of species make this extrapolation more difficult Uncertainty

Due to the lack of correlation with human physiology, the traditional toxicokinetic model is difficult to accurately predict the internal exposure concentration of chemicals and their metabolites to the target, and it is also difficult to extrapolate the prediction results to different exposure scenarios, exposure routes and species

[0009] At present, the relevant research on bisphenol A is mostly limited to the correlation and mutual derivation between the external exposure dose and the content of bisphenol A in the urine of the population, and the health effects of bisphenol A in the human body depend on the level of unconjugated bisphenol A in the blood As well as the content level of bisphenol A in target organs and target tissues, the actual measurement of this level requires obtaining blood samples from the population and various organs and tissues for testing, and blood sampling is an invasive operation, which is costly and has low cooperation among the population, so it cannot be popularized and applications, and human organs and tissues cannot be sampled and monitored

[0010] Considering that the metabolic parameters of bisphenol A are different in rodents and humans, the physiological toxicokinetic model of bisphenol A applicable to rodents cannot be applied to humans; in addition, bisphenol A metabolism is different in primates and humans. There is no enterohepatic circulation, so it is not advisable to include the human bisphenol A physiological toxicity kinetic model with enterohepatic circulation

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