The invention relates to the field of
public health, particularly relates to
chemical risk assessment, and especially relates to a physiological poison
metabolism kinetic model for adults exposed to
bisphenol A through mouths. The construction method of the model comprises the following steps: S1, determining a kinetic process of absorption, distribution,
metabolism and
excretion of the bisphenolA orally taken in a
human body; S2, determining a physiological poison
metabolism kinetic model structure of the adults exposed to
bisphenol A through the mouths; S3, establishing a
mathematical model, and compiling a
differential equation; S4, acquiring human physiological parameters,
bisphenol A biochemical parameters and
bisphenol A toxicokinetic parameters; and S5, carrying out
simulation andparameter optimization on the physiological poison metabolism
kinetic model of the
bisphenol A. The model and the method disclosed by the invention are helpful to establish
bisphenol A internal and external
exposure association of the
human body, simulate the content level of bisphenol A in a
target organ, and further clarify an effect mechanism and a
dose-reaction relationship of the bisphenol Ain combination with an effect index of the bisphenol A, so that the
health risk that people are exposed to bisphenol A through the mouths can be evaluated more accurately, and important scientific basic data are provided for making and correcting bisphenol A limit values.