The invention provides an exit-entry chemical risk assessment method and system and a readable storage medium. The method comprises the following steps: acquiring document information of a to-be-assessed target article; obtaining enterprise information, type information, quality information, packaging information, transportation environment information and transportation time information of the target article according to the document information; calculating an environmental hazard assessment score, a health hazard assessment score and a physical hazard assessment score according to the enterprise information, the type information and the quality information; calculating a transportation hazard assessment score according to the type information, the packaging information, the transportation environment information and the transportation time information; and calculating a total risk assessment score of the target cargo according to the environmental hazard assessment score, the health hazard assessment score, the physical hazard assessment score and the transportation hazard assessment score.