Preparation method of porous nano-hydroxyapatite sustained-release gel

A technology of nano-hydroxyapatite and hydroxyapatite, which is applied in the field of materials, can solve the problems of reducing the biological activity and toxicity of porous hydroxyapatite, and achieve the effects of enhancing suspension stability, accelerating metabolism time, and good drug release

Active Publication Date: 2019-12-06
SHANGHAI MOYANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The organic template method needs to select a suitable surfactant. In some cases, the selected surfactant may be toxic and needs to be removed at high temperature, which reduces the biological activity of porous hydroxyapatite.

Method used

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  • Preparation method of porous nano-hydroxyapatite sustained-release gel
  • Preparation method of porous nano-hydroxyapatite sustained-release gel
  • Preparation method of porous nano-hydroxyapatite sustained-release gel

Examples

Experimental program
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Effect test

Embodiment 1

[0028] A method for preparing a porous nano-hydroxyapatite sustained-release gel of the present embodiment, the method comprises the following steps:

[0029] Step 1: adding nano-hydroxyapatite powder into water to prepare a hydroxyapatite slurry with a content of 10-40% (w / v);

[0030] Step 2: Mix the hydroxyapatite slurry, the pore-forming agent and the oleic acid in proportion, wherein the weight ratio of the hydroxyapatite slurry to the pore-forming agent is 80:20. Put it in a ball mill for 6-24 hours, and get a uniform suspension after ball milling; the pore-forming agent is carbon powder.

[0031] Step 3: adding the organic compounding agent to the suspension for mixing in proportion, and then putting it into a water bath at 80° C. for stirring and dissolving; the organic compounding agent is a combination of gelatin, gum arabic, chitosan and sodium alginate. The stirring speed of the water bath was 600r / min, and the dissolution time was 5h.

[0032] Step 4: spray-dryi...

Embodiment 2

[0038] A method for preparing a porous nano-hydroxyapatite sustained-release gel of the present embodiment, the method comprises the following steps:

[0039] Step 1: adding nano-hydroxyapatite powder into water to prepare a hydroxyapatite slurry with a content of 10-40% (w / v);

[0040] Step 2: Mix the hydroxyapatite slurry, the pore-forming agent and the oleic acid in proportion, wherein the weight ratio of the hydroxyapatite slurry to the pore-forming agent is 85:15. Put it in a ball mill for 6-24 hours, and get a uniform suspension after ball milling; the pore-forming agent is carbon powder.

[0041] Step 3: The suspension is added with an organic compounding agent to mix in proportion, and then put into a 50°C water bath to stir and dissolve; the organic compounding agent is a combination of gelatin, gum arabic, chitosan and sodium alginate. The stirring rate of the water bath was 250r / min, and the dissolution time was 5h.

[0042] Step 4: spray-drying and granulating th...

Embodiment 3

[0048] A method for preparing a porous nano-hydroxyapatite sustained-release gel of the present embodiment, the method comprises the following steps:

[0049] Step 1: adding nano-hydroxyapatite powder into water to prepare a hydroxyapatite slurry with a content of 10-40% (w / v);

[0050] Step 2: Mix the hydroxyapatite slurry, the pore-forming agent and the oleic acid in proportion, wherein the weight ratio of the hydroxyapatite slurry to the pore-forming agent is 95:5. Put it in a ball mill for 6-24 hours, and get a uniform suspension after ball milling; the pore-forming agent is carbon powder.

[0051] Step 3: The suspension is added with an organic compounding agent to mix in proportion, and then put into a 50°C water bath to stir and dissolve; the organic compounding agent is a combination of gelatin, gum arabic, chitosan and sodium alginate. The stirring rate of the water bath was 250r / min, and the dissolution time was 5h.

[0052] Step 4: spray-drying and granulating the...

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Abstract

The invention provides a preparation method of porous nano-hydroxyapatite sustained-release gel. Hydroxyapatite composite microspheres prepared by the method provided by the invention have uniform size distribution, a particle size distribution range of 10-100 mu m, and a central particle size of 20-60 mu m. Increase of an organic phase in a mixing process can effectively enhance the suspension stability of a suspension; the prepared microspheres have uniform size distribution and a larger particle size than the microspheres prepared by a traditional spray-drying method, and can be used as aninternal support material of injections; and the microspheres have a good spherical shape and high porosity, can enhance the injectability of a material, help to accelerate the metabolism time of drugs, maintain a stable and effective drug concentration in the body, and have good drug-release properties.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a preparation method of porous nano-hydroxyapatite slow-release gel. Background technique [0002] Hydroxyapatite (HAP) has attracted extensive attention from biomaterials and medical experts due to its close structure and composition to human bone tissue. As a bone filling material, HAP is used in orthopedics, stomatology and plastic surgery. In addition, HAP is also used as a carrier for growth factors, drugs, etc., and shows good sustained release properties. To meet different clinical needs, researchers prepared HAPs in different shapes such as rods, dumbbells, spheres, and sheets. Spherical hydroxyapatite has attracted great attention due to its strong fluidity, large specific surface area, and high bulk density. [0003] There are many methods for preparing hydroxyapatite microspheres, such as hydrothermal method, emulsification cross-linking method, microwa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/52A61L27/56A61L27/54
CPCA61L27/12A61L27/52A61L27/54A61L27/56A61L2400/12A61L2300/602A61L2430/02A61L2430/12A61K9/1611A61L27/20A61L27/58A61L2400/06A61K9/06A61K47/36C08L5/04
Inventor 不公告发明人
Owner SHANGHAI MOYANG BIOTECHNOLOGY CO LTD
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