The invention provides a medical cold-compressing paster which comprises a back lining layer, a gel layer and a covering layer. The gel layer is prepared from raw materials, the raw materials include,by mass, 2%-15% of a polymer substance, 2%-10% of an epidermal growth factor, 2%-8% of ceramide, 3%-8% of a moisturizer, 3%-10% of a radix bupleuri extract, 2%-8% of a dandelion extract, 3%-12% of agolden cypress extract, 5%-10% of an aloe extract, 2%-10% of a honeysuckle flower extract and the balance purified water. The invention also provides a preparation method of the medical cold-compressing paster. The medical cold-compressing paster has the advantages that the medical cold-compressing paster is convenient to use; the medical cold-compressing paster achieves both cold-compressing cooling and pain relieving, also promotes organization healing; the biocompatibility is good, and the medical cold-compressing paster does not have sensitization and irritation; the drug release performance is good, and the application time is long; the medical cold-compressing paster provides different shapes, and the different demands are met; the preparation method is easy to operate, the raw materials are wide in source, the preparation cost is low, no toxic-side effect is produced, and the medical cold-compressing paster is safe and reliable.