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Medicament carrier for releasing medicament in sustained-release way

A technology of drugs and carriers, applied in the field of drug carriers for sustained-release drug release, can solve problems such as incomplete drug release at the end

Inactive Publication Date: 2012-10-03
钟术光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] One of the main purposes of the present invention is to provide a drug carrier with improved performance for sustained release. Problems such as "drug release first and then slow" or "incomplete drug release at the end" shown in the test were alleviated or resolved

Method used

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  • Medicament carrier for releasing medicament in sustained-release way
  • Medicament carrier for releasing medicament in sustained-release way
  • Medicament carrier for releasing medicament in sustained-release way

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0236]

[0237] Note: a1, the main performance parameters of this particle are shown in Table 1;

[0238] b1, the preparation method of the sodium polyacrylate particles: see the preparation method of the acidic (or alkaline) water-insoluble and swellable polymer (particle) in the comparative example below.

Embodiment 2

[0240]

[0241] Note: a2, the main performance parameters of this particle are shown in Table 1;

[0242] b2, the preparation method of the polylysine citrate particles: see the preparation method of the acidic (or alkaline) water-insoluble and swellable polymer (particle) in the comparative example below.

Embodiment 3

[0244]

[0245] Note: a3, the main performance parameters of this particle are shown in Table 1;

[0246] b3, the preparation method of the sodium polyacrylate particles: see the preparation method of the acidic (or alkaline) water-insoluble and swellable polymer (particle) in the comparative example below.

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PUM

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Abstract

The invention discloses a medicament carrier for releasing a medicament in a sustained-release way. The medicament carrier comprises (a) an aliphatic additive of which the melting points in vivo and vitro are higher than 37 DEG C, (b) water-soluble, low-viscosity and non-irritating additive particles, (c) a water-swellable and water-insoluble acidic (or alkaline) polymer, (d) an alkaline (or acidic) substance, (e) a water-soluble surfactant and (f) a medicament. The medicament carrier has high medicament release properties, a good anti-salt poisoning effect and high medicament release uniformity, so that the medicament can be released in a sustained way or the problem about end-release is solved; the medicament carrier has low mucous membrane irritation and high biocompatibility; and the medicament safety problems such as medicament burst release and dose pour release are not easily caused.

Description

technical field [0001] The invention relates to a medicine carrier for sustained release of medicine. More specifically, the present invention relates to a drug carrier for sustained-release drug with improved properties, the drug carrier includes aliphatic additives with in vivo and in vitro melting points greater than 37°C, water-soluble low-viscosity additive particles, water Swellable water-insoluble acidic (or basic) polymer, basic (or basic) excipient (material), water-soluble surfactant and drug. technical background [0002] Sustained-release preparations such as sustained-release suppositories, especially those with oily materials as the main sustained-release material, often exhibit the so-called "terminal release" problem, that is, the release of the drug is fast in the early stage, gradually slows down in the middle stage, and slows down in the later stage. Often, a part of the drug remains in the matrix within the specified (or expected) action time, and the ex...

Claims

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Application Information

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IPC IPC(8): A61K47/14A61K47/16A61K47/26A61K47/32A61K47/34A61K47/36A61K47/38A61K47/40A61K47/42A61K9/02
CPCA61K9/0002A61K9/02A61K9/1635A61K9/1641A61K9/2013A61K9/2018A61K9/2031A61K9/2077A61K38/14A61K47/06A61K47/14A61K47/183A61K47/26A61K47/34A61K47/36A61K47/40A61K47/42A61K47/44
Inventor 钟术光
Owner 钟术光
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