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Drug carrier releasing drug slowly

A technology of drugs and carriers, applied in the field of drug carriers for sustained-release drug release, can solve problems such as incomplete drug release at the end

Inactive Publication Date: 2016-11-23
钟术光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] One of the main purposes of the present invention is to provide a drug carrier with improved performance for sustained release. Problems such as "drug release first and then slow" or "incomplete drug release at the end" shown in the test were alleviated or resolved

Method used

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  • Drug carrier releasing drug slowly
  • Drug carrier releasing drug slowly
  • Drug carrier releasing drug slowly

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0236]

[0237] Note: a1, the main performance parameters of this particle are shown in Table 1;

[0238] b1, the preparation method of the sodium polyacrylate particles: see the preparation method of the acidic (or alkaline) water-insoluble and swellable polymer (particle) in the comparative example below.

Embodiment 2

[0240]

[0241] Note: a2, the main performance parameters of this particle are shown in Table 1;

[0242] b2, the preparation method of the polylysine citrate particles: see the preparation method of the acidic (or alkaline) water-insoluble and swellable polymer (particle) in the comparative example below.

Embodiment 3

[0244]

[0245] Note: a3, the main performance parameters of this particle are shown in Table 1;

[0246] [b3, the preparation method of the sodium polyacrylate particles: see the preparation method of the acidic (or alkaline) water-insoluble and swellable polymer (particle) in the comparative example below.

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Abstract

The invention discloses a drug carrier releasing a drug slowly; the drug carrier includes: (a), an aliphatic additive melting in vivo and in vitro at a temperature of 37 DEG C and above; (b), water-soluble, low-viscosity and nonirritating additive particles; (c), a water-swellable and water-insoluble acidic (or alkaline) polymer; (d), an alkaline (or acidic) substance; (e), a water-soluble surfactant; (f) a drug. The drug carrier has better drug release characteristics, higher anti-'salt-poisoning' effect and better drug release uniformity, and better alleviates or solves the 'end release' problem; the drug carrier has low mucosal irritation and better biocompatibility; the drug carrier rarely presents usage problems such as sudden drug release or dosage decline.

Description

technical field [0001] The invention relates to a medicine carrier for sustained release of medicine. More specifically, the present invention relates to a drug carrier for sustained-release drug with improved properties, the drug carrier includes aliphatic additives with in vivo and in vitro melting points greater than 37°C, water-soluble low-viscosity additive particles, water Swellable water-insoluble acidic (or basic) polymer, basic (or basic) excipient (material), water-soluble surfactant and drug. technical background [0002] Sustained-release preparations such as sustained-release suppositories, especially those with oily materials as the main sustained-release material, often exhibit the so-called "terminal release" problem, that is, the release of the drug is fast in the early stage, gradually slows down in the middle stage, and slows down in the later stage. Often, a part of the drug remains in the matrix within the specified (or expected) action time, and the ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/14A61K47/06A61K47/44A61K47/18A61K47/26A61K47/34A61K47/36A61K47/32A61K47/40A61K47/42A61K38/14A61K9/20A61K9/22A61K9/16A61K9/48
CPCA61K47/14A61K9/0002A61K9/1635A61K9/1641A61K9/2013A61K38/14A61K47/06A61K47/183A61K47/26A61K47/34A61K47/36A61K47/40A61K47/42A61K47/44
Inventor 钟术光
Owner 钟术光
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