Slow-release medicine carrier

A drug and carrier technology, applied in the field of drug carriers for sustained release of drugs, can solve problems such as drug safety issues

Inactive Publication Date: 2011-03-09
钟术光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It should be pointed out that the drug carrier disclosed by this technology may also have drug safety problems such as sudden drug release or dose-dumping.

Method used

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Examples

Experimental program
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Embodiment Construction

[0031] The following is a detailed description of the above-mentioned drug carrier.

[0032] Fatty acid glycerides with a melting point higher than 37°C and a melting point higher than 37°C when in contact with body fluids in the body cavity are used as the matrix of the drug carrier and the material for controlling drug release in the present invention. The fatty acid glycerides used in the present invention can be, for example, fatty acid monoglycerides, fatty acid diglycerides, fatty acid triglycerides and mixtures thereof, where the fatty acids are usually mixed fatty acids with carbon atoms of C14-C18. The melting point of these fatty acid glycerides must be higher than the temperature of 37°C, but preferably not higher than 45°C, more preferably not higher than 42°C. Examples of fatty acid glycerides useful in the present invention are CP (melting point 37-39°C), C, CM, CS2, CS2X, CT (melting point 38-40°C), D, DM, ND (melting point 42-45°C) (manufactured by Gattefosse...

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Abstract

The invention discloses a slow-release medicine carrier with improved performance, which includes (a) fatty glyceride whose melting point in vivo and vitro is more than 37 DEG C; (b) additive particles which are soluble in water, has low viscosity and no irritation; (c) an acidic (or alkalic) polymer with water swelling ability and water insolubility; (d ) an alkalic (or acidic) surfactant; and (e) a medicament. The medicament carrier has better medicament-release characteristic, high salt poisoning resistance, low irritation to mucous membrane, better biological compatibility and better medicament-release homogeneity and better relieves or solves the problem of end release; and meanwhile it is not easy to generate medicament safety problems such as burst release or dose dumping of medicament.

Description

technical field [0001] The invention relates to a medicine carrier for sustained release of medicine. More specifically, the present invention relates to a drug carrier for sustained-release drugs with improved properties, the drug carrier includes fatty acid glycerides with melting point greater than temperature 37 in vivo and in vitro, water-soluble low-viscosity additive particles, water-swellable Water-insoluble acidic polymers, alkaline surfactants and drugs. technical background [0002] Sustained-release preparations such as sustained-release suppositories, especially those with oily materials as the main sustained-release material, often exhibit the so-called "terminal release" problem, that is, the release of the drug is fast in the early stage, gradually slows down in the middle stage, and slows down in the later stage. Often, a part of the drug remains in the matrix within the specified (or expected) action time, and cannot play the expected role, or it is manife...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/30A61K47/32A61K47/38A61K47/36A61K47/34A61K47/40A61K45/00A61K9/02A61K9/00
Inventor 钟术光
Owner 钟术光
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