3results about How to "High drug loading efficiency" patented technology

The present application relates to the technical field of nanomedicine, in particular to a β-cyclodextrin-carboxymethyl chitosan-deoxycholic acid nanoparticle carrying ginsenoside CK, a preparation method and application. A first esterification reaction is performed between a β-cyclodextrin solution and a carboxyl-activated carboxymethyl chitosan solution to obtain a β-cyclodextrin-carboxymethyl chitosan polymer; a second esterification or amidation reaction is performed by adding carboxyl-activated deoxycholic acid to the β-cyclodextrin-carboxymethyl chitosan polymer to obtain a β-cyclodextrin-carboxymethyl chitosan-deoxycholic acid polymer; an ethanol solution of ginsenoside CK is mixed with a water solution of the β-cyclodextrin-carboxymethyl chitosan-deoxycholic acid polymer to obtain a whole particle, and a freeze-drying protective agent is added for freeze-drying to obtain the β-cyclodextrin-carboxymethyl chitosan-deoxycholic acid nanoparticle carrying ginsenoside CK. The present application focuses on the design of an intelligent carrier, realizes the synergistic optimization of high drug loading and intelligent delivery, and overcomes the defects of the prior art.

The invention discloses an application of a Lamp2b-IMTP fusion exosome in treatment of coronary heart disease. The specific application method comprises the following steps: preparing an exosome matrix, carrying out optimization treatment on the exosome matrix, and finally, specifically combining the optimized exosome matrix with myocardial cells through IMTP on the surface of the Lamp2b-IMTP fusion exosome in an intravenous injection administration mode. Therapeutic substances are accurately delivered to damaged myocardial tissues, which is the core advantage of the fused exosome and is also the basis of subsequent treatment effects: IMTP (myocardial targeting peptide) is modified on the surface of the exosome, and the IMTP can be accurately combined with a specific receptor on the surface of a damaged myocardial cell.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a hyaluronic acid-modified co-supported nanoparticle, its preparation method, and its application. The nanoparticle has a core-shell structure, with the core being a coordination complex of zinc-doped Prussian blue and sinomenine hydrochloride, and the outer shell being a bovine serum albumin-hyaluronic acid conjugate. This invention improves the therapeutic effect on knee osteoarthritis.