6results about How to "High drug loading efficiency" patented technology

The invention belongs to the technical field of medical materials, and particularly relates to a degradable wound dressing and a preparation method thereof. Compared with the prior art, the degradable wound dressing prepared by the preparation method disclosed by the invention is a completely biodegradable Janus composite film, and a hydrophobic inner layer and a hydrophilic outer layer are obtained by selecting different materials; the material PGA with excellent biological performance is utilized, the problem that electrostatic spinning cannot be carried out through pure PGA is solved, PGA and gelatin are creatively mixed, the advantages of PGA and gelatin are combined, and the PGA / Gel electrostatic spinning film which is high in toughness, high in tensile strength, good in biocompatibility and high in medicine carrying efficiency is obtained; meanwhile, the functions of resisting bacteria, resisting inflammation, discharging seepage and promoting angiogenesis are achieved, and the wound healing rate is effectively guaranteed.

The invention relates to the technical field of biomedical materials, in particular to a hydrogel microneedle for skin improvement and a preparation method thereof.The hydrogel microneedle for skin improvement comprises a microneedle matrix and fisetin, the microneedle matrix is a hydrogel matrix, and the fisetin is embedded in the microneedle matrix. According to the hydrogel microneedle for skin improvement, the hydrogel microneedle has good mechanical performance, biocompatibility and degradability, the effect of slowly releasing medicine can be achieved, the hydrogel matrix wraps fisetin, the targeting performance of anti-aging active ingredients can be effectively enhanced, and the anti-aging effect of the skin is improved. The anti-aging agent is slowly released in a corium layer to play an anti-aging role, and has a wide application prospect in medical beauty and skin care products.

The present invention relates to a stimulus-responsive dual-drug co-delivery micelle and a preparation method and application thereof, belonging to the field of polymer chemistry and pharmaceutical preparation. The present invention uses doxorubicin (DOX) directly as a hydrophobic block, and bonds with the hydrophilic block mPEG through a disulfide bond that can respond to a high concentration of glutathione in the tumor microenvironment to form an mPEG-SS-DOX micelle material, and uses molecular dynamics simulation screening to obtain the Flory-Huggins interaction parameter between curcumin (Cur) and the hydrophobic end of mPEG-SS-DOX to be the smallest. The self-assembly process of drug-loaded micelles and the effect of drug loading on the morphology and structure of micelles are studied by dissipative particle dynamics simulation. The mPEG-SS-DOX / Cur micelles with redox responsiveness are successfully prepared, and the micelle particle size is small, the surface is negatively charged, and the drug loading and encapsulation efficiency are good.

The present application relates to the technical field of nanomedicine, in particular to a β-cyclodextrin-carboxymethyl chitosan-deoxycholic acid nanoparticle carrying ginsenoside CK, a preparation method and application. A first esterification reaction is performed between a β-cyclodextrin solution and a carboxyl-activated carboxymethyl chitosan solution to obtain a β-cyclodextrin-carboxymethyl chitosan polymer; a second esterification or amidation reaction is performed by adding carboxyl-activated deoxycholic acid to the β-cyclodextrin-carboxymethyl chitosan polymer to obtain a β-cyclodextrin-carboxymethyl chitosan-deoxycholic acid polymer; an ethanol solution of ginsenoside CK is mixed with a water solution of the β-cyclodextrin-carboxymethyl chitosan-deoxycholic acid polymer to obtain a whole particle, and a freeze-drying protective agent is added for freeze-drying to obtain the β-cyclodextrin-carboxymethyl chitosan-deoxycholic acid nanoparticle carrying ginsenoside CK. The present application focuses on the design of an intelligent carrier, realizes the synergistic optimization of high drug loading and intelligent delivery, and overcomes the defects of the prior art.

The invention discloses an application of a Lamp2b-IMTP fusion exosome in treatment of coronary heart disease. The specific application method comprises the following steps: preparing an exosome matrix, carrying out optimization treatment on the exosome matrix, and finally, specifically combining the optimized exosome matrix with myocardial cells through IMTP on the surface of the Lamp2b-IMTP fusion exosome in an intravenous injection administration mode. Therapeutic substances are accurately delivered to damaged myocardial tissues, which is the core advantage of the fused exosome and is also the basis of subsequent treatment effects: IMTP (myocardial targeting peptide) is modified on the surface of the exosome, and the IMTP can be accurately combined with a specific receptor on the surface of a damaged myocardial cell.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a hyaluronic acid-modified co-supported nanoparticle, its preparation method, and its application. The nanoparticle has a core-shell structure, with the core being a coordination complex of zinc-doped Prussian blue and sinomenine hydrochloride, and the outer shell being a bovine serum albumin-hyaluronic acid conjugate. This invention improves the therapeutic effect on knee osteoarthritis.