70results about How to "High drug loading efficiency" patented technology

The invention discloses a preparation method and application of a conductive hydrogel capable of slowly releasing drugs and factors. The preparation method comprises the following steps: step 1, a conductive macromolecular monomer solution is prepared, an oxidant is added, and after sufficient reaction, a conductive macromolecular polymer is obtained; step 2, a concentrated aqueous dopamine solution is prepared, the conductive macromolecular polymer obtained in step 1 is added, and after sufficient reaction, a polydopamine/conductive macromolecular polymer compound is obtained; step 3, a metalion salt solution and an organic ligand solution are prepared; step 4, the polydopamine/conductive macromolecular polymer compound is added into the metal ion salt solution, and after uniform mixing,the organic ligand solution is added; and reaction is sufficiently carried out; step 5, the metal-organic framework/polydopamine/conductive macromolecular polymer compound is added into a monomer ordouble-bond biomacromolecular solution; and after additive is added, the needed hydrogel is formed by polymerization. The conductive hydrogel has excellent conductivity and electrochemical activity, and can be used in the preparation of drug carriers and biological electrodes.

The invention provides a preparation method of a hepatoma carcinoma cell targeted molybdenum disulfide drug-loaded nano tablets. The preparation method comprises following steps: step 1, molybdenum disulfide nano tablets are obtained via hydro-thermal synthesis; step 2, the molybdenum disulfide nano tablets are added into a gelatin solution, and gelatinized molybdenum disulfide nano tablets are obtained via sufficient reaction; step 3, lactobionic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, and N-hydroxy succinimide are weighed and added into the gelatinized molybdenum disulfide nano tablets so as to obtain lactobionic acid modified molybdenum disulfide nano tablets; and step 4, a doxorubicin hydrochloride aqueous solution is prepared, and the lactobionic acid modified molybdenum disulfide nano tablets obtained via step 3 are added into the doxorubicin hydrochloride aqueous solution, an obtained mixture is stirred for 8 to 24h under vacuum conditions, and is subjected to centrifugalization and washing so as to obtain the hepatoma carcinoma cell targeted molybdenum disulfide drug-loaded nano tablets via collecting. The hepatoma carcinoma cell targeted molybdenum disulfide drug-loaded nano tablets can be used for photothermal therapy and CT imaging, and can be used for realizing combination of diagnosis and treatment of hepatoma carcinoma.

The invention relates to a preparation method of a macromolecular multi-layered hydrogel drug sustained-release material. The preparation method mainly includes steps of performing laminar superimposition function on the proper mixture ratio and composition of polyanion macromolecular blended solution A and polycation macromolecular blended solution B through a micro-bedding co-extruding device, sealing and placing the solution A and solution B to make them crosslink slowly and completely to realize structuring of macromolecular polyelectrolyte loaded with drugs, and to prepare a macromolecular polyelectrolyte hydrogel drug loading system with flexible and controllable drug form distribution, flexible and controllable drug sustained-release performance and having alternative multilayered structure, so as to meet different drug sustained-release demands. Compared with the traditional method of preparing the macromolecular multi-layered hydrogel drug sustained-release material by superimposition layer by layer, the method is a continuous production method, and good for improving the production efficiency; the technique is simple, and product quality index between different batches is stable; the preparation can realize the large-scale industrial production, is wide in application scale and has wide industrial and market prospect.

The invention discloses an ultrasonic controlled release medicine elution balloon catheter and a preparation method. The surface of the medicine elution balloon catheter is coated with a medicine coating, the medicine coating is composed of a fat-soluble medicine carrying microcapsule having a ultrasonic response characteristic and an adhesive having a water-soluble characteristic. Medicine of the medicine elution balloon catheter is wrapped in a lipophilic medicine carrying microcapsule which is hard to dissolve in the blood, so medicine loss caused by blood washing can be reduced. When the ultrasonic controlled release medicine elution balloon catheter is used, the medicine elution balloon catheter is sent to a lesion portion and unfolds, a balloon contacts with the lesion tissues, ultrasound inducts the lesion portion at the external, the medicine carrying microcapsule can be speeded up to be separated from the hydrophilic adhesive, medicine can diffuse in the fat-soluble lesion tissues, at the same time, the medicine carrying microcapsule having the ultrasonic response characteristic breaks under the function of the ultrasound and discharges the medicine, the efficiency of medicine absorption and utilization by the target lesion tissues can be greatly raised. The amount and time of medicine discharge can be controlled through adjusting the characteristic and the ultrasonic characteristic of the medicine carrying microcapsule, the validity and safety of the medicine elution balloon catheter can be improved.

The invention discloses a preparation method of macromolecular laminar drug-loaded hydrogel with controllable drug distribution. The preparation method mainly includes steps of performing multiple times of laminar superimposition on polyanion macromolecular blended solution A with appropriate proportion and composition and polycation macromolecular blended solution B with appropriate proportion and composition through a microlayer co-extrusion device, and sealing and placing to allow the solution A and the solution B to crosslink slowly and completely to realize structuring of drug-loaded macromolecular polyelectrolyte so as to prepare a macromolecular hydrogel drug loading system with flexible and controllable drug form distribution and drug release performance and with an alternative multilayered structure to meet different drug release demands. Compared with a traditional method using layer-by-layer superposition to prepare the macromolecular laminar drug-loaded hydrogel, the method has the advantages that the method is a continuous production method and beneficial to the improving of production efficiency; the method is simple in process, the product quality indexes of different batches of produces are stable, and the method is capable of achieving large-scale industrial production, wide in application range and promising in industrialization and market prospect.

The invention discloses a tumor-targeted photodynamic medicine carrying nanoparticle as well as a preparation method and an application thereof, belonging to a medical preparation containing porphyrin or a medical preparation prepared by a method which utilizes wave energy to process materials. According to the invention, porphyrin or derivates of porphyrin of a functional group and polyethylene glycol and polypropylene glycol of a polyether chain segment are connected through chemical bonds or ester bonds or amido bonds of perssads, and then polymerized into a nanoparticle aqueous dispersion of porphyrin or derivates, loaded with a chemotherapy drug with a conjugated structure and dialyzed to obtain the tumor-targeted photodynamic medicine carrying nanoparticle. The nano material prepared by the method is high in yield, regular in shape, uniform in distribution and good in biosecurity, can be effectively loaded with an antitumor drug with a conjugated structure; a water-soluble photosensitizer can effectively reverse drug tolerance of a chemotherapy drug after being irradiated by near-infrared light; the nanoparticle can efficiently target and position tumors, has good anelasticity, effectively inhibits tumor growth, and has a wide application prospect in preparing breast cancer tumor-targeted drugs.

The invention discloses a fusion protein, the amino acid sequence of which contains an iRGD peptide sequence shown as SEQ ID No:1 and a molecular chaperone GroEL sequence shown as SEQ ID No:2. The invention further discloses an encoding gene of the fusion protein, the sequence of which is a nucleotide sequence capable of encoding the fusion protein. The invention further discloses a preparation method of the fusion protein. The preparation method comprises the following step of expressing the encoding gene in a bacterial strain to obtain the fusion protein. A method of preparing a pharmaceutical composition comprises the following steps of contacting the pharmaceutical compound with the fusion protein disclosed by the invention to obtain a contacted material in the presence of a solvent. The invention further discloses the pharmaceutical composition prepared by the method of preparing the pharmaceutical composition. The fusion protein provided by the invention can stably load a hydrophobic drug, and is high in drug-carrying efficiency and good in drug release effect. The pharmaceutical composition prepared by the fusion protein provided by the invention has the advantages of good biocompatibility and good drug release effect.

The invention discloses application of targeted reduction response vesicular nanometer medicines in preparation of brain tumor treatment medicines. Reduction sensitive reversible crosslinking vesiclesbased on block polymers PEG-P(TMC-DTC), PEG-P(LA-DTC), PEG-P(TMC-DTC)-PEI, PEG-P(LA-DTC)-PEI, PEG-P(TMC-DTC)-Sp or PEG-P(LA-DTC)-Sp and targeting polymers with ANG as the targeting molecules can efficiently wrap small-molecular chemotherapy medicines, protein medicines and gene medicines sensitive to brain glioma cells. The medicine-carrying vesicles can efficiently permeate through a blood brainbarrier in vivo to enter tumor substances and can also rapidly release medicines after entering tumor cells to induce cell apoptosis. The system has the advantages that the process is simple, the carrier biocompatibility is good, the enrichment of medicines at brain tumor parts is remarkably improved, and the concentration of medicines in brain tumor cells is increased. By means of the system, medicines can be conveyed to brain glioma selectively and efficiently.

The invention discloses a compound traditional Chinese medicine micro needle transdermal patch for treating psoriasis and a preparation method. The compound traditional Chinese medicine micro needle transdermal patch is prepared from medical raw materials including rhizoma bletillae, rhizoma areactylodis lanceae, sichuan coptis roots, realgar, golden larch bark, herba ephedrae, chaulmoogratree seeds, radix saposhnikoviae, scolopendra, aurine, fructus cnidii and herba schizonepetae and auxiliaries including polysorbate-80, granulesten, glycerin monostearate and tacrolimus. The patch is composed of a base plate, medicament, an ointment blank patch body and an ointment back patch body, the front face of the base plate is provided with a plurality of micro needles, micro needle gaps are formed among the micro needles, the back face of the base plate is pasted to the inner surface of the ointment blank patch body, the inner surface of the ointment back patch body is arranged on the front face of the base plate in a covering mode, and the inner surface of the ointment blank patch body and the inner surface of the ointment back patch body are fixedly connected in a pasting mode. The invention further discloses preparation steps of the micro needle transdermal patch. The micro needle transdermal patch has the advantages of being precise in medicine components, free of pain, capable of being released slowly, efficient and convenient to apply.

The invention discloses a biocompatible cross-linking micro-nano material for drug encapsulation and sustained release and a preparation technology of the biocompatible cross-linking micro-nano material for drug encapsulation and sustained release. A biological material takes polyacrylate microbubbles or nano particles as a matrix, chitosan as a coating material, genipin as a cross-linking agent and doxorubicin as a model drug, and drug encapsulation and release characteristics are investigated. The micro-nano material prepared according to the preparation technology has the advantages that the entrapment efficiency and the encapsulation efficiency are improved to a certain degree, and the in-vitro drug release speed can be controlled moderately. The preparation technology has the advantages of simple steps, mild conditions, technological environment friendliness, low energy consumption, no 'three wastes', no radiation and no noise, thereby being a universal technology for biocompatible cross-linking of micro-nano particles.

The invention belongs to the technical field of medicines and discloses a cyclosporine A and amphiphilic hyaluronic acid derivative composition and a preparation method thereof. The composition is prepared from cyclosporine A and the amphiphilic hyaluronic acid derivative. The composition has the characteristics of high medicine loading capacity, good stability and good biocompatibility and can overcome such defects of the ophthalmic cyclosporine preparations as lower bioavailability and toxic and side effects. The preparation method is simple and is convenient to use.

The invention discloses a compound traditional Chinese medicine micro needle transdermal patch for treating scapulohumeral periarthritis and a preparation method. The compound traditional Chinese medicine micro needle transdermal patch is prepared from medical materials including poria, manyflower solomonseal rhizomes, cortex eucommiae, cortex cinnamomi, herba schizonepetae, rhizoma chuanxiong, roots or stems of smoothfruit ventilago, Japanese creeper, leaves or roots of dentate wampee, silvery aleuritopteris and radix angelicae pubescentis and auxiliaries including polysorbate-80, granulesten, glycerin monostearate and tacrolimus. The patch is composed of a base plate, medicament, an ointment blank patch body and an ointment back patch body, the front face of the base plate is provided with a plurality of micro needles, micro needle gaps are formed among the micro needles, the medicament is stored in the micro needle gaps and a porous structure of the base plate, the back face of the base plate is pasted to the inner surface of the ointment blank patch body, the inner surface of the ointment back patch body is arranged on the front face of the base plate in a covering mode, and the inner surface of the ointment blank patch body and the inner surface of the ointment back patch body are fixedly connected in a pasting mode. The invention further discloses preparation steps of the micro needle transdermal patch. The micro needle transdermal patch has the advantages of being precise in medicine composition, free of pain, capable of being released slowly, efficient and convenient to apply.

The invention discloses nimesulide solid dispersion micro-powder. The nimesulide is prepared by using povidone and hydroxypropyl methylcellulose as dispersion carrier materials and carrying out supercritical fluid crystallization. According to the invention, the preparation method of nimesulide solid dispersion micro-powder is operated simply under mild conditions; the controllability is high; andno solvent residue is left. The obtained nimesulide solid dispersion micro-powder is small in particle size, high in dispersity and high in stability; and the saturated solubility can reach over 5 times of that of a nimesulide raw material medicine (pH = 6.8). The micro-powder can be used for preparing solubilizing quick-release particles of nimesulide; the rapid dissolving in the dissolution medium with the pH value of 6.8 is realized; and the equilibrium dissolution rate of the micro-powder is more than two times of those of bulk drugs and nimesulide particles. Besides, the micro-powder canalso be used for preparing nimesulide tablets, capsules or suspensions and the like.

The invention discloses a photo-thermal responsive drug carrier based on nano titanium nitride and a microcapsule and a preparation method. The preparation method comprises the following steps, firstly, carboxylating the surface of a poly epsilon-caprolactone drug-loaded microcapsule by using alkaline solution, and then modifying amino groups on the surfaces of nano titanium nitride particles; andfinally, compounding the carboxylated drug-loaded microsphere and the titanium nitride nanoparticles with the surfaces modified by the amino groups through electrostatic interaction to obtain the titanium nitride microcapsule composite drug carrier. The microsphere prepared by the method has high drug loading rate. Titanium nitride can directly convert light energy into heat energy after being irradiated by near-infrared light, so that the composite microsphere is molten by heating, thereby improving drug release efficiency. The photo-thermal responsive drug carrier has simple preparation process and high heat production capacity at illumination, and can realize remote, high-precision and high-efficiency release of drugs. The drug-loaded microsphere has wide application prospects in the fields of clinical treatment, anti-corrosive coatings, etc.