44results about How to "Overcoming multidrug resistance" patented technology

A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.

The invention discloses composite micelle carrying an anti-tumor medicine and a preparation method thereof. The composite micelle is prepared from the following raw materials: pluronic, an amphiphilic block copolymer, an anti-tumor medicine, an organic solvent and water, wherein the mass ratio of the pluronic to the amphiphilic block copolymer is 1-1000:10; the mass ratio of the total mass of thepluronic and the amphiphilic block copolymer to the anti-tumor medicine is 2-100:1. The invention combines the advantages of the pluronic and the amphiphilic block copolymer, and the prepared composite micelle has uniform particle diameter and can overcome a multidrug resistance action. Fluorescent HPLC proves that the composite micelle can obviously increase the intracellular accumulation of themedicine and can be applied to the field of the reversion of the multidrug resistance of tumors. The invention has simple preparation method and very good application prospect.

The present invention relates to a preparation method of multi-level sustained-release drug-loaded nano-short fibers, comprising layered double hydroxide (LDH) loaded with anticancer drug doxorubicin (DOX) and P-gp inhibitor α-growth Phenolsuccinate (α-TOS) was mixed together in poly(lactic-co-glycolic acid) (PLGA) spinning solution for electrospinning and homogenized. The present invention constructs double-loaded multi-level slow-release drug-loaded nano-short fibers with organic and inorganic dual carriers. The anticancer drugs and P-gp inhibitors in the material can be released in multiple levels in the slightly acidic environment of the tumor, and are used to overcome cancer. The multi-drug resistance of cells, the double-carrier nanofiber prolongs the drug release path, realizes the long-term sustained release of anticancer drugs, and provides a new method for the long-term effective treatment of drug-resistant tumors.

The invention discloses a mixed micelle freeze-dried preparation loaded with docetaxel. A preparation method of the mixed micelle freeze-dried preparation loaded with docetaxel comprises the following steps of: dissolving docetaxel, a Pluronic surfactant and a diblock copolymer into an organic solvent, rotationally evaporating the organic solvent out under reduced pressure under a water bath condition, and standing in vacuum to obtain a dry and transparent medicament film; heating the medicament film in a water bath, melting a solid framework, adding water of the same temperature for hydrating, and cooling to the room temperature to obtain a transparent docetaxel mixed micelle solution; and adding a freeze-drying protecting agent into the docetaxel mixed micelle solution, degerming with a microporous filtering film, and performing freeze drying to obtain a mixed micelle freeze-dried preparation of docetaxel, wherein the average particle diameter of the mixed micelle freeze-dried preparation is 17-25 nanometers. According to the mixed micelle freeze-dried preparation loaded with docetaxel disclosed by the invention, the solubility of docetaxel is increased greatly; and a prepared micelle has small particle diameter and high envelop rate, has the characteristics of passive targeting, long circulation and the like, and has a very good application prospect.

The invention provides ammonia borane / hollow mesoporous polydopamine / polyethylene glycol nanocomposite particles, the chemical formula of the nanocomposite particles is AB@HMPDA‑PEG, with solid silica as the core and mesoporous polydopamine as the shell , etched with hydrofluoric acid to obtain hollow mesoporous polydopamine HMPDA, PEG-modified on the surface of the shell, and then encapsulated ammonia borane AB small-molecule prodrug by hydrogen bond force. The invention also provides the preparation method and application of the nanocomposite particles. Compared with the prior art, the AB@HMPDA‑PEG nanocomposite particles of the present invention can target anticancer drugs and gaseous prodrugs to the cancer site, increase the long circulation time in the body while reducing the toxic side effects on normal tissues and cells , Overcome multidrug resistance to kill cancer cells more efficiently, further improve the therapeutic effect, and have great potential in promoting the combined application of gas therapy and cancer chemotherapy, and enhancing the efficacy of cancer treatment.