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Metal organic framework coated nano-particles capable of automatically supplying H2O2/O2 and consuming GSH as well as preparation method and application of metal organic framework coated nano-particles

A metal-organic framework and H2O2 technology, applied in the field of nanomedicine, can solve problems such as limiting the application of CDT/PDT, achieve excellent consumption of GSH, avoid multi-drug resistance, and promote effective uptake

Pending Publication Date: 2022-08-05
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, tumor tissue hypoxia, GSH overexpression and H 2 o 2 Insufficient levels severely limit the further application of CDT / PDT

Method used

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  • Metal organic framework coated nano-particles capable of automatically supplying H2O2/O2 and consuming GSH as well as preparation method and application of metal organic framework coated nano-particles
  • Metal organic framework coated nano-particles capable of automatically supplying H2O2/O2 and consuming GSH as well as preparation method and application of metal organic framework coated nano-particles
  • Metal organic framework coated nano-particles capable of automatically supplying H2O2/O2 and consuming GSH as well as preparation method and application of metal organic framework coated nano-particles

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051] According to another typical embodiment of the present invention, a self-supply H is provided 2 O 2 / O 2 And a preparation method of metal-organic framework-coated nanoparticles consuming GSH, the method comprising:

[0052] Step S1, obtaining calcium peroxide nanoparticles;

[0053] The step S1 specifically includes:

[0054] Anhydrous CaCl 2 Dissolve in methanol, add H 2 O 2 Mix well, then add NH 3 ·H 2 O stirred the reaction, washed with methanol and dispersed in methanol to obtain calcium peroxide nanoparticles.

[0055] As a specific embodiment, the anhydrous CaCl 2 The mass-volume ratio to the methanol ranges from (0.2 to 0.6) g: (20 to 60) ml;

[0056] The methanol, H 2 O 2 and NH 3 ·H 2 The volume ratio of O ranges from (20 to 40): (0.4 to 1): (0.3 to 0.6). The addition ratio is beneficial to obtain calcium peroxide nanoparticles with uniform size and hydrated particle size of 70 nm to 110 nm.

[0057] Step S2, coating a metal-organic framework o...

Embodiment 1

[0080] Embodiment 1, self-supply H 2 O 2 / O 2 and GSH-consuming metal-organic framework-coated nanoparticles and methods for their preparation

[0081] (1) CaO 2 Preparation of nanoparticles:

[0082] Weigh 0.2234g of anhydrous CaCl 2 Dissolve in 30ml methanol, dissolve by ultrasonic, slowly add 500ulH 2 O 2 , stir and mix; then add 300 μl NH 3 ·H 2 O, stirred for 1 h, washed with methanol 3 times, and finally dispersed in methanol, which is CaO 2 Nanoparticles.

[0083](2) Preparation of metal-organic frameworks coated with peroxide nanoparticles:

[0084] S1. 0.2389g Zn (NO 3 ) 2 ·6H 2 O and 0.0543g Cu(NO 3 ) 2 Dissolve in 20ml methanol, sonicate uniformly to obtain solution a;

[0085] S2. Dissolve 0.3287g of 2-methylimidazole in 10ml of methanol, and sonicate uniformly to obtain solution b;

[0086] S3. The solution a obtained in step S1. is added to the calcium peroxide methanol solution prepared in step 1), and the ultrasonic wave is uniform;

[0087] S...

experiment example 2

[0090] Experimental example 2. Micro-morphological characterization

[0091] The CCZIL nanoparticle powder prepared in Example 1 was placed on a silicon wafer, the silicon wafer was fixed on the sample stage with conductive glue, and the microscopic morphology of the sample surface was observed with a field emission scanning electron microscope. like figure 2 As shown in a, the CCZIL nanoparticles are spherical and uniform in size; and the particle size of CCZIL is 50±5 nm. TEM observations of CCZIL were performed in a similar manner ( figure 2 b), the results are consistent with SEM.

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Abstract

The invention discloses a metal organic framework coated nano-particle capable of automatically supplying H2O2 / O2 and consuming GSH and a preparation method and application of the metal organic framework coated nano-particle. The metal organic framework coated nano-particle is a core-shell structure compound and comprises a calcium peroxide nano-particle inner core, a calcium peroxide nano-particle outer core and a metal organic framework coated nano-particle inner core, the periphery of the calcium peroxide nanoparticle core is coated with the metal organic framework shell, and pores of the metal organic framework are loaded with a photosensitizer; and the phase change material is modified on the peripheral surface of the metal organic framework shell. The prepared nano-particles automatically supply H2O2 / O2 and consume GSH, can effectively enhance the PDT / CDT curative effect, can be combined with chemotherapy drugs to amplify chemotherapy, avoids multi-drug resistance, and realizes multi-mode synergistic therapy of tumor photothermal therapy, photodynamic therapy, chemical dynamic therapy and chemotherapy.

Description

technical field [0001] The invention relates to the technical field of nanometer medicine, in particular to a self-supplying H 2 O 2 / O 2 and GSH-consuming metal-organic framework-coated nanoparticles and their preparation methods and applications. Background technique [0002] Currently, cancer is still one of the greatest threats to human security, among which breast cancer is the most common female malignancy in the world and the leading cause of cancer death in women worldwide. In recent years, researchers have developed various therapeutic strategies to inhibit tumor growth, which have greatly improved the survival of tumor patients. [0003] Chemotherapy is still one of the most commonly used clinical anti-cancer methods in traditional and emerging cancer treatment methods, but chemotherapy often has problems such as large systemic toxicity, multidrug resistance, and poor patient compliance. In addition, monotherapy is often difficult to achieve complete tumor supp...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/69A61P35/00
CPCA61K41/0052A61K41/0057A61K47/6949A61K47/6929A61P35/00A61K2300/00
Inventor 郭惠玲左静洁郝思远张溢
Owner HUBEI UNIV OF TECH
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