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Magnetic nano-drug carrier based on porous gadolinium-doped iron oxide nano-cluster and preparation method of magnetic nano-drug carrier

A technology of iron oxide nanometer and magnetic nanometer, which is applied in the direction of nanomedicine, nanotechnology for sensing, photodisintegration of medicine in vivo, etc., can solve the problems of lack of improvement in the accuracy of image diagnosis, and achieve excellent magnetization, Overcoming effects of multidrug resistance

Active Publication Date: 2020-12-08
XINXIANG MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Lack of consideration to improve the accuracy of imaging diagnosis

Method used

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  • Magnetic nano-drug carrier based on porous gadolinium-doped iron oxide nano-cluster and preparation method of magnetic nano-drug carrier
  • Magnetic nano-drug carrier based on porous gadolinium-doped iron oxide nano-cluster and preparation method of magnetic nano-drug carrier
  • Magnetic nano-drug carrier based on porous gadolinium-doped iron oxide nano-cluster and preparation method of magnetic nano-drug carrier

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Embodiment

[0040] In this example, a magnetic nano-drug carrier based on porous gadolinium-doped iron oxide nanoclusters is prepared, and the specific preparation method is as follows:

[0041] 1) Preparation of porous gadolinium-doped iron oxide nanoclusters (PGIONC)

[0042] A modified solvothermal method was used to synthesize PGIONC with uniform size and high stability. The specific steps are as follows; a certain proportion of FeCl 3 ·6H 2 O and GdCl 3 ·6H 2 O was dissolved in a mixed solution of ethylene glycol (15ml) and polyethanol (30ml) and stirred at 80°C for 30 minutes, and a certain proportion of polyglutamic acid (PGA) and ammonium acetate (NH 4 OAc), stirred and heated at 120° C. for 1 hour under nitrogen protection to obtain a homogeneous transparent solution. Subsequently, it was sealed in a Teflon-lined stainless steel autoclave, heated to 200°C, aged for 8 hours, cooled to room temperature, and washed repeatedly with ethanol and deionized water to obtain black PGIO...

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Abstract

The invention relates to the technical field of medical nano-materials, in particular to a magnetic nano-drug carrier based on a porous gadolinium-doped iron oxide nano-cluster and a preparation method of the magnetic nano-drug carrier. The magnetic nano-drug carrier is characterized in that the gadolinium-doped iron oxide nano-cluster serves as a core, the surface area of the gadolinium-doped iron oxide nano-cluster is large, the surface of the gadolinium-doped iron oxide nano-cluster is rich in hydroxyl, and particularly, the gadolinium-doped iron oxide nano-cluster synthesizing a mesoporousstructure can load high-content anti-cancer drugs. According to the drug carrier, a peripheral degradable shell layer can effectively prevent non-specific release of the anti-cancer drug, and after the drug reaches a target site, the shell layer material is degraded through pH value and external near-infrared light stimulation, the gadolinium-doped iron oxide nano-cluster loaded with the drug isexposed, and the drug release is realized; and meanwhile, the gadolinium-doped iron oxide nano-cluster shows excellent magnetization intensity due to the characteristic that sub-nanoparticles of the gadolinium-doped iron oxide nano-cluster are closely integrated, and can be applied to a T1-T2 magnetic resonance image contrast agent.

Description

technical field [0001] The invention relates to the technical field of medical nanomaterials, in particular to a magnetic nanomedicine carrier based on porous gadolinium-doped iron oxide nanoclusters and a preparation method thereof. Background technique [0002] Cancer is one of the major diseases threatening human life and health, and chemotherapy is the most commonly used treatment. However, while traditional chemotherapy kills tumor cells, it also kills normal cells, destroys the human immune system, and has the disadvantage of being prone to recurrence. Therefore, the development of chemotherapeutic drug delivery and drug release systems that can target and kill cancer cells can reduce the side effects of radiotherapy on normal cells and improve the therapeutic effect, which is of great significance for the realization of efficient and safe tumor treatment. The present invention is a magnetically targeted anticancer drug delivery system based on nanoparticles. [0003...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K47/02A61K47/34A61K47/60A61K47/54A61K47/69A61K31/704A61K41/00A61P35/00A61K49/12A61K49/10A61K49/18B82Y5/00B82Y15/00
CPCA61K9/5115A61K9/5146A61K47/60A61K47/545A61K47/6935A61K31/704A61K41/0042A61P35/00A61K49/126A61K49/10A61K49/186A61K49/1833B82Y5/00B82Y15/00A61K2300/00
Inventor 金珍李佳解琳艳常金龙赵俊强于毅任武于勉
Owner XINXIANG MEDICAL UNIV
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