Magnetic nano-drug carrier based on porous gadolinium-doped iron oxide nano-cluster and preparation method of magnetic nano-drug carrier

A technology of iron oxide nanometer and magnetic nanometer, which is applied in the direction of nanomedicine, nanotechnology for sensing, photodisintegration of medicine in vivo, etc., can solve the problems of lack of improvement in the accuracy of image diagnosis, and achieve excellent magnetization, Overcoming effects of multidrug resistance

Active Publication Date: 2020-12-08
XINXIANG MEDICAL UNIV
View PDF13 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lack of consideration to improve

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Magnetic nano-drug carrier based on porous gadolinium-doped iron oxide nano-cluster and preparation method of magnetic nano-drug carrier
  • Magnetic nano-drug carrier based on porous gadolinium-doped iron oxide nano-cluster and preparation method of magnetic nano-drug carrier
  • Magnetic nano-drug carrier based on porous gadolinium-doped iron oxide nano-cluster and preparation method of magnetic nano-drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0039] Example

[0040] Preparation Example of the present embodiment based magnetic nanoparticle drug carrier gadolinium doped porous iron oxide clusters, specifically prepared as follows:

[0041] 1) preparation of a porous doped gadolinium iron oxide nanoclusters (PGIONC)

[0042] Using a modified solvothermal synthesis of uniform size, high stability PGIONC, the specific steps are as follows; a percentage of FeCl 3 · 6h 2 O and GdCl 3 · 6h 2 O was dissolved in ethylene glycol (15ml) and poly ethanol (30ml) and the mixture was stirred at 80 ℃ 30 min, the reaction system in a certain proportion of the poly-glutamic acid (PGA) and ammonium acetate (NH 4 OAc), stirred under nitrogen at 120 deg.] C for 1 hour to obtain a uniform clear solution. Subsequently, sealed Teflon-lined stainless steel autoclave and heated to 200 ℃, aged eight hours after cooling to room temperature, and washed with ethanol and repeatedly with deionized water to give a black PGIONC; overall configuration an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to view more

Abstract

The invention relates to the technical field of medical nano-materials, in particular to a magnetic nano-drug carrier based on a porous gadolinium-doped iron oxide nano-cluster and a preparation method of the magnetic nano-drug carrier. The magnetic nano-drug carrier is characterized in that the gadolinium-doped iron oxide nano-cluster serves as a core, the surface area of the gadolinium-doped iron oxide nano-cluster is large, the surface of the gadolinium-doped iron oxide nano-cluster is rich in hydroxyl, and particularly, the gadolinium-doped iron oxide nano-cluster synthesizing a mesoporousstructure can load high-content anti-cancer drugs. According to the drug carrier, a peripheral degradable shell layer can effectively prevent non-specific release of the anti-cancer drug, and after the drug reaches a target site, the shell layer material is degraded through pH value and external near-infrared light stimulation, the gadolinium-doped iron oxide nano-cluster loaded with the drug isexposed, and the drug release is realized; and meanwhile, the gadolinium-doped iron oxide nano-cluster shows excellent magnetization intensity due to the characteristic that sub-nanoparticles of the gadolinium-doped iron oxide nano-cluster are closely integrated, and can be applied to a T1-T2 magnetic resonance image contrast agent.

Description

technical field [0001] The invention relates to the technical field of medical nanomaterials, in particular to a magnetic nanomedicine carrier based on porous gadolinium-doped iron oxide nanoclusters and a preparation method thereof. Background technique [0002] Cancer is one of the major diseases threatening human life and health, and chemotherapy is the most commonly used treatment. However, while traditional chemotherapy kills tumor cells, it also kills normal cells, destroys the human immune system, and has the disadvantage of being prone to recurrence. Therefore, the development of chemotherapeutic drug delivery and drug release systems that can target and kill cancer cells can reduce the side effects of radiotherapy on normal cells and improve the therapeutic effect, which is of great significance for the realization of efficient and safe tumor treatment. The present invention is a magnetically targeted anticancer drug delivery system based on nanoparticles. [0003...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/52A61K47/02A61K47/34A61K47/60A61K47/54A61K47/69A61K31/704A61K41/00A61P35/00A61K49/12A61K49/10A61K49/18B82Y5/00B82Y15/00
CPCA61K9/5115A61K9/5146A61K47/60A61K47/545A61K47/6935A61K31/704A61K41/0042A61P35/00A61K49/126A61K49/10A61K49/186A61K49/1833B82Y5/00B82Y15/00A61K2300/00
Inventor 金珍李佳解琳艳常金龙赵俊强于毅任武于勉
Owner XINXIANG MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap