PKI-587-based anticancer intermediate and polyethylene glycol-coupled anticancer drug, preparation method and application thereof

A technology of PKI-587 and polyethylene glycol, which is applied in the field of cancer treatment, can solve the problems of limited clinical curative effect, achieve significant clinical value, broad market prospects, and reduce toxicity
CN107670050BActive Publication Date: 2019-06-07CHONGQING UPGRA BIOLOGICAL SCI & TECH LTD
4 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHONGQING UPGRA BIOLOGICAL SCI & TECH LTD
Publication Date
2019-06-07

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides an anticancer intermediate based on PKI-587 and a polyethylene glycol coupled anticancer drug, and preparation methods and application thereof, belonging to the field of treatment of cancers. The anticancer intermediate has a general structural formula as described in the specification, and at least one AC in the general structural formula is the anticancer drug PKI-587. Thepolyethylene glycol coupled anticancer drug has a general structural formula as described in the specification. The above two drugs can realize combined medication of the targeting anticancer drug PKI-587 and a plurality of other anticancer drugs, so toxic response caused by mutual influence and pharmacokinetics of a plurality of other anticancer drugs can be prevented during individual administration of the anticancer drugs, multidrug resistance of cancers is overcome, and synergistic effect is exerted; and the two drugs can be used for preparing anticancer drugs with targeting effect and have critical clinical value and wide market prospects.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to the field of cancer treatment, in particular to a PKI-587-based anticancer intermediate and polyethylene glycol-coupled anticancer drug, as well as its preparation method and application. Background technique

[0002] Cancer, a very complex and deadly disease, is a huge health crisis currently being experienced by both developed and developing countries. In 2012, there were more than 14 million new cancer cases worldwide, and by 2020, there will be more than 15 million new cancer patients worldwide, which will have serious consequences for the society, economy and medical treatment of any country. influences.

[0003] Clinical outcomes of cancer treatment are generally disappointing, due in large part to the heterogeneity and complexity of this devastating disease. Traditional surgery and radiotherapy are only used for the treatment of localized disease, while hormone therapy, chemotherapy, immunotherapy and targeted ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More