A kind of composition and preparation method for childbirth containing procaine

A technology of procaine and composition, which is applied in the field of composition for delivery and its preparation, can solve problems such as hypersensitivity and anaphylaxis, methemoglobin disease, etc., to prolong the action time, prevent pneumonia, eliminate inhibitory effect

Active Publication Date: 2018-04-20
东营市东凯新材料技术研发有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug may have hypersensitivity and allergic reactions, and individual patients may experience hyperthermia

Method used

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  • A kind of composition and preparation method for childbirth containing procaine
  • A kind of composition and preparation method for childbirth containing procaine

Examples

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Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: a kind of composition that is used for childbirth containing procaine, its dosage form is injection, by procaine 30mg, epinephrine 0.03mg, fentanyl 0.01mg, atropine 0.2 in every 100 milliliters of injections mg, sodium chloride 1mg, hydrochloric acid 1mg and the balance of water for injection.

[0037] The above-mentioned preparation method of the composition for childbirth containing procaine, comprises the steps:

[0038] 1) Dissolve procaine, fentanyl, atropine, and sodium chloride in water for injection, and stir to dissolve;

[0039] 2) Add epinephrine into hydrochloric acid, stir to dissolve;

[0040] 3) Mix the liquid medicine in step 1) and 2) evenly, and add an appropriate amount of hydrochloric acid to adjust the pH value to 3;

[0041] 4) Add water for injection to the full amount of the liquid medicine in step 3), add medicinal charcoal, stir for 5 minutes, and let stand for 10 minutes. Filter through titanium rod filter 0.45µm, 0.22µm cartrid...

Embodiment 2

[0043] Embodiment 2: a kind of composition that is used for childbirth containing procaine, its dosage form is injection, by procaine 40mg, epinephrine 0.07mg, fentanyl 0.05mg, atropine 0.8 in every 100 milliliters of injections mg, sodium chloride 5mg, hydrochloric acid 10mg and the balance of water for injection.

[0044] The preparation method of the composition for childbirth containing procaine of the present invention comprises the steps:

[0045] 1) Dissolve procaine, fentanyl, atropine, and sodium chloride in water for injection, and stir to dissolve;

[0046] 2) Add epinephrine into hydrochloric acid, stir to dissolve;

[0047] 3) Mix the liquid medicine in step 1) and 2) evenly, and add an appropriate amount of hydrochloric acid to adjust the pH value to 5;

[0048] 4) Add water for injection to the full amount of the liquid medicine in step 3), add medicinal charcoal, stir for 10 minutes, and let stand for 20 minutes. Filter through titanium rod filter 0.45µm, 0....

Embodiment 3

[0050] Embodiment 3: a kind of composition that is used for childbirth containing procaine, its dosage form is injection, in every 100 milliliters of injections, by procaine 33mg, epinephrine 0.04mg, fentanyl 0.02mg, atropine 0.4 mg, sodium chloride 2mg, hydrochloric acid 4mg and the balance of water for injection.

[0051] The preparation method of the composition for childbirth containing procaine of the present invention may further comprise the steps:

[0052] 1) Dissolve procaine, fentanyl, atropine, and sodium chloride in water for injection, and stir to dissolve;

[0053] 2) Add epinephrine into hydrochloric acid, stir to dissolve;

[0054] 3) Mix the liquid medicine in step 1) and 2) evenly, and add an appropriate amount of hydrochloric acid to adjust the pH value to 4;

[0055] 4) Add water for injection to the full amount of the liquid medicine in step 3), add medicinal charcoal, stir for 7 minutes, and let stand for 13 minutes. Filter through titanium rod filter ...

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PUM

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Abstract

The invention belongs to the field of medicine, and discloses a composition for childbirth containing procaine. The composition adopts injections, and every 100 milliliters of injections consists of 30-40 mg of procaine, 0.03-0.07 mg of epinephrine, Fentanyl 0.01-0.05mg, atropine 0.2-0.8mg, sodium chloride 1-5mg, hydrochloric acid 1-10mg and the balance of water for injection. The present invention is used for labor analgesia, which is easy to administer, has quick onset, reliable effect, no toxic and side effects, and can meet the needs of the whole labor analgesia. Compared with the prior art, the action time of procaine is prolonged, and It can correspondingly reduce the bleeding in the operation area, avoid the poisoning reaction caused by high blood drug concentration, and eliminate the inhibition of respiration by procaine.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a composition for childbirth containing procaine and a preparation method thereof. Background technique [0002] The ideal labor analgesic effect is: little impact on mother and baby, easy to administer, quick onset, reliable effect, can meet the needs of analgesia throughout the labor process, avoid motor nerve block, do not affect uterine contraction and maternal movement, and make the mother awake , can participate in the delivery process, and can meet the needs of surgery if necessary. [0003] Procaine (English name: Procaine), solid state is white crystal or crystalline powder, easily soluble in water, less toxic, its chemical name is 2-(diethylamino)ethyl 4-aminobenzoate. The molecular formula is C13H20N2O2, the molecular weight is 236.31, the CAS number is 59-46-1, and its structural formula is as follows: [0004] [0005] Procaine is a short-acting lipid local a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K9/14A61K31/46A61P15/00A61P29/00A61P23/02A61K31/137A61K31/4468A61K31/245
Inventor 段鹏静上官世金
Owner 东营市东凯新材料技术研发有限责任公司
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