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Polydopamine and polyethylene glycol vitamin E succinate-modified mesoporous silica nanoparticle as well as preparation method and application thereof

A technology of mesoporous silica and polyethylene glycol, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problems affecting the efficacy of anticancer drugs, lung cancer treatment obstacles, The clinical application of anti-drug-resistant drugs is slow and other problems, to achieve the effect of overcoming multi-drug resistance, good biocompatibility and biodegradability, and simple preparation methods

Active Publication Date: 2017-06-09
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapy and radiation therapy are relatively early development and widely used treatment methods, but they have the following disadvantages: On the one hand, both small cell lung cancer and non-small cell lung cancer have certain drug resistance to some drugs, which affects the Efficacy of anticancer drugs, a great obstacle to the treatment of lung cancer
At present, there are very few reports on the successful clinical application of drug carriers with anti-multidrug resistance functions in vivo, resulting in slow progress in the clinical application of anti-drug resistance drugs

Method used

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  • Polydopamine and polyethylene glycol vitamin E succinate-modified mesoporous silica nanoparticle as well as preparation method and application thereof
  • Polydopamine and polyethylene glycol vitamin E succinate-modified mesoporous silica nanoparticle as well as preparation method and application thereof
  • Polydopamine and polyethylene glycol vitamin E succinate-modified mesoporous silica nanoparticle as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A method for preparing polydopamine and polyethylene glycol 1000 vitamin E succinate modified mesoporous silica nanoparticles for drug-resistant lung cancer treatment, comprising the steps of:

[0046] (1) Weigh 100 mg of mesoporous silica MSNs and 10 mg of doxorubicin hydrochloride powder, dissolve them in 8 ml of deionized water, react in the dark for 12 hours under stirring conditions, centrifuge at 10,000 rpm for 15 min, discard the supernatant, and use Washed three times with deionized water to remove free doxorubicin, and the precipitate was vacuum-dried to obtain initial silica spherical nanoparticles MSNs-DOX loaded with doxorubicin;

[0047] (2) Resuspend the initial nanoparticle MSNs-DOX in 10mM Tris buffer solution with pH=8.5 according to the ratio of 5mg:1mL, add dopamine hydrochloride to make the concentration 0.5mg / mL, react for 3 hours, 10000rpm Centrifuge for 20 min, collect the precipitate, wash three times with deionized water to remove unreacted dopa...

Embodiment 2

[0061] A method for preparing polydopamine and polyethylene glycol 1000 vitamin E succinate modified mesoporous silica nanoparticles for drug-resistant lung cancer treatment, comprising the steps of:

[0062] (1) Weigh 100mg mesoporous silica MSNs and 2mg doxorubicin, dissolve in 8ml deionized water, react for 6 hours under stirring conditions, centrifuge at 20000rpm for 15min, discard the supernatant, wash with deionized water, and Remove free doxorubicin, and vacuum-dry the precipitate to obtain doxorubicin-loaded mesoporous silica primary nanoparticles MSNs-DOX;

[0063] (2) The initial mesoporous silica nanoparticles MSNs-DOX were resuspended in 10 mM PBS buffer solution with pH=8.5 according to the ratio of 1 mg:1 mL, and dopamine hydrochloride was added to make the concentration 0.2 mg / mL, React for 5 hours, centrifuge at 20,000rpm for 15min, collect the precipitate, wash with deionized water to remove unreacted dopamine hydrochloride, and dry in vacuum to obtain mesopor...

Embodiment 3

[0068] A method for preparing polydopamine and polyethylene glycol 1000 vitamin E succinate modified mesoporous silica nanoparticles for drug-resistant lung cancer treatment, comprising the steps of:

[0069] (1) Weigh 100 mg of mesoporous silica MSNs and 20 mg of paclitaxel (Paclitaxel, DTX), dissolve in 10 ml of dimethyl sulfoxide, react for 12 hours under stirring conditions, centrifuge at 15,000 rpm for 15 min, discard the supernatant, Wash with deionized water to remove free paclitaxel and solvent dimethyl sulfoxide, precipitate and vacuum dry to obtain paclitaxel-loaded mesoporous silica primary nanoparticles MSNs-DTX;

[0070] (2) resuspend the initial mesoporous silica nanoparticles MSNs-DTX in 10mM Tris buffer solution with pH=8.5 according to the ratio of 10mg:1mL, add dopamine hydrochloride to make the concentration 1.0mg / mL, React in the dark for 12 hours, centrifuge at 15000rpm for 20min, collect the precipitate, wash with deionized water to remove unreacted dopam...

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Abstract

The invention provides a polydopamine and polyethylene glycol vitamin E succinate-modified mesoporous silica nanoparticle as well as a preparation method and application thereof. Specifically, the preparation method of the polydopamine and polyethylene glycol vitamin E succinate-modified mesoporous silicon dioxide nanoparticle comprises the following steps: 1) dissolving mesoporous silicon dioxide and a drug into a solvent, reacting to be complete and separating to obtain a drug-loaded mesoporous silica initial nanoparticle; 2) adding the initial nanoparticle into a solution, adding dopamine hydrochloride, reacting to be complete and separating to obtain a drug-loaded polybutadiene-wrapped mesoporous silica nanoparticle; 3) adding the polybutadiene-wrapped mesoporous silica nanoparticle into a weak base aqueous solution, adding polyethylene glycol 1000 vitamin E succinate, reacting to be complete and separating to obtain a tumor targeting mesoporous silica nanoparticle. The nanoparticle provided by the invention is simple in preparation method, free from pollution and good in biocompatibility and biodegradability, and has a treatment effect on a lung cancer.

Description

technical field [0001] The invention relates to a mesoporous silica nanoparticle modified with polydopamine and polyethylene glycol 1000 vitamin E succinate for the treatment of drug-resistant lung cancer, a preparation method and application thereof. Background technique [0002] The lung is an important respiratory organ of the human body, it can also play a role in regulating body temperature, and it is also a part of the immune system. Therefore, the lung is one of the most critical organs of the human body, but it is also one of the most vulnerable organs of the human body. Lung cancer is one of the malignant tumors with the fastest-growing morbidity and mortality and the greatest threat to human health and life. Among them, the incidence and mortality of lung cancer in men account for the first of all malignant tumors, and the incidence and mortality of lung cancer in women account for second. In view of its high morbidity and mortality, lung cancer has seriously thr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/34A61K47/14A61K47/04A61P35/00A61K31/704A61K31/337A61K33/24A61K31/513A61K31/37
CPCA61K9/146A61K31/337A61K31/37A61K31/513A61K31/704A61K33/24A61K47/02A61K47/14A61K47/34
Inventor 曾小伟梅林黄来强程伟刘赣杨彪
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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