5results about How to "Induced death" patented technology

The invention relates to the technical field of nano biological medicines, and discloses a photo-thermal-enzyme catalysis nano-particle as well as a preparation method and application thereof. The photo-thermal-enzyme catalysis nano-particles are constructed by crosslinking water-soluble self-doped polyaniline nano-particles, human serum albumin, lactate oxidase and collagenase through a thioacetal linker capable of being split by active oxygen. Collagenase and lactate oxidase (LOx) are integrated into the same nanoparticle system through a thioacetal (TK) linker, the TK linker is split under the action of tumor microenvironment active oxygen (ROS) and H2O2 generated by catalysis of the LOx, the activity of the two enzymes is synchronously activated, a collagen matrix (physical barrier) is degraded, lactic acid (chemical barrier) is removed, the tumor microenvironment is efficiently remodeled, and the tumor microenvironment can be effectively inhibited. The problems that the regulation effect of a single barrier is limited, and the tumor microenvironment is difficult to improve are solved.

The present application relates to the technical field of biological products, and provides an application of Ganoderma lucidum exosomes in the treatment of brain glioma, an extraction method and a composition, and the application of Ganoderma lucidum exosomes in any one or more of the following: a) preparing a product that promotes apoptosis of brain glioma cells; b) preparing a product that inhibits proliferation of brain glioma cells; c) preparing a product that inhibits autophagy of brain glioma cells; d) preparing a product for treating brain glioma. The present application verifies through cell and animal experiments that Ganoderma lucidum exosomes can effectively induce apoptosis of brain glioma cells and inhibit autophagy of brain glioma cells to induce glioma death, and act on brain glioma cells through the AKT / mTOR signaling pathway and inhibiting the production of autophagosomes in brain glioma cells.

This invention relates to the field of biomedical technology, specifically to the application of an organic photosensitive acid generator in the preparation of antitumor drugs. In this invention, an organic photoresponsive molecular system is constructed. The organic photosensitive acid generator possesses the synergistic effect of photoacid therapy (PAT) and photodynamic therapy (PDT), enhancing the efficacy of photoactivated therapy and improving the reliability and effectiveness of tumor treatment. Under ultraviolet light irradiation of a specific wavelength, the organic photosensitive acid generator produces a large amount of H₂. + Reactive oxygen species (ROS) can damage the DNA, proteins, and lipids of tumor cells, thereby inducing cell death.

The present invention discloses a functional drug-carrying small molecule peptide that promotes ferroptosis of breast cancer cells, and belongs to the technical field of the establishment and preparation of small molecule peptide nano drug carrier systems. The functional small molecule peptide responds to the slight acidity in the tumor microenvironment and can be used as a drug carrier, and the structural formula is shown in Figure 1. The functional drug-carrying small molecule peptide system PS / Pep1 of the present invention can target the coagulation plasma protein in tumor blood vessels, and can increase the cytotoxicity to tumor cells and reduce the toxic side effects to normal cells. PS / Pep1 undergoes a morphological change in the tumor microenvironment, and it co-loads PTX and SF, which increases the retention time of the combined drug in tumor cells. Compared with PS / Pep2, which cannot be morphologically transformed, PS / Pep1 more effectively inhibits tumor growth. More importantly, PS / Pep1 can effectively induce ferroptosis of breast cancer cells.

This invention discloses a ZIF-8 nanomedicine delivery system co-loaded with doxorubicin and siTDRKH, its preparation method, and its applications, belonging to the fields of biomedicine and nanomaterials technology. The nanomedicine delivery system uses the zeolite imidazole ester framework material ZIF-8 as a carrier. Its porous structure encapsulates the chemotherapeutic drug doxorubicin within the framework, and small interfering RNA targeting the TDRKH gene is loaded onto the surface through electrostatic adsorption. This structure exhibits high pH responsiveness: it remains stable under normal physiological conditions (pH 7.4), preventing premature drug leakage; upon entering the slightly acidic environment of a tumor (pH 6.5) or a lysosomal environment (pH 5.0), the ZIF-8 framework immediately disintegrates, achieving targeted and synergistic release of the loaded drug.