Procaspase-activating compounds and compositions

a technology applied in the field of active compounds and compositions, to achieve the effect of reducing adverse reactions
US20130096133A1Active Publication Date: 2013-04-18THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
Publication Date
2013-04-18

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Abstract

The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.
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Description

RELATED APPLICATIONS

[0001] This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Patent Application No. 61 / 547,135, filed Oct. 14, 2011, which is incorporated herein by reference in its entirety.GOVERNMENT SUPPORT

[0002] This invention was made with government support under R01-CA120439 awarded by the National Institutes of Health. The United States Government has certain rights in the invention.BACKGROUND OF THE INVENTION

[0003] Apoptosis is a process used by higher organisms to maintain homeostasis by removing cells that are in excess, damaged, or potentially dangerous. Critical to apoptosis is the activation of caspase enzymes, a class of cysteine proteases that cleave cellular substrates after recognition sequences with C-terminal aspartate residues. There are two canonical apoptotic pathways, differing in that the apoptosis-initiating stimulus is intracellular (intrinsic pathway) or extracellular (extrinsic pathway). These pathways converge at the cleavage of ...

Claims

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