55results about How to "Inhibition of ubiquitination" patented technology

The invention relates to an anti-efflorescence joint sealing mortar. The motor comprises, by weight, 210-250 parts of ordinary Portland cement, 25-35 parts of high alumina cement, 440-540 parts of sand, 40-60 parts of silica fume, 180-220 parts of coal ash, 3-8 parts of bentonite, 2-4 parts of redispersable latex powder, 1-1.5 parts of cellulose ether, 2-3 parts of a wood fiber, 0.2-0.6 parts of citric acid, and 3-5 parts of a stearate. The anti-efflorescence joint sealing mortar provided in the invention allows the ordinary Portland cement and the high alumina cement to be mixed according to a ratio of 6:1-10:1 through a compound technology, so factors causing the mortar efflorescence are fundamentally eliminated, the compactness of the mortar is improved, the mortar aperture number is reduced, and no efflorescence phenomenon appearance in the use process of the mortar is guaranteed.

The invention discloses efforescence resistant colored wall finishing mortar, which is prepared from the following raw materials in percentage by weight: 12%-20% of high-alumina cement, 5%-10% of white cement, 65%-75% of quartz sand, 0.1%-3% of inorganic pigment, 2%-4% of active nanometer SiO2, 2%-4% of redispersible powder, 0.1%-1% of a defoamer, 0.1%-1% of a wood fiber and 0.1%-0.6% of cellulose ether. By adopting a binary gelled material taking the high-alumina cement as a main material and the white cement as an auxiliary material, and matching with the active nanometer SiO2 and the redispersible powder as additives, the strength of the finishing mortar is ensured, the problem of efforescence of the finishing mortar can be effectively solved, the overall decorative effect of the finishing mortar is greatly improved, and the late wall maintenance cost is reduced.

The invention discloses a thin dry powder fire-resistant coating for a steel structure. The fire-resistant coating is prepared from, by weight, white cement, titanium dioxide, calcined kaolin, calcium carbonate, polydimethylsiloxane, polymer-modified oxidized graphene, sulfonated polybenzimidazole-modified meso-porous silicon, KH-560 and aeolian sand. The thin dry powder fire-resistant coating for the steel structure has the advantages that the fire resistance is excellent, the adhesive force is high, the wear resistance is good, the weather resistance, the water resistance and the radiation resistance are good, a surface layer of the coating is smooth and fine, and greenness and environmental friendliness are achieved.

The invention discloses a dry powder reflective thermal insulation coating, comprising the following components according to weight proportions: Portland cement, light calcium carbonate, calcined kaolin, silicon carbide, fly ash hollow float beads, sodium sulfide, polydimethylsiloxane, polymer modified graphene oxide and KH-560. The dry powder reflective thermal insulation coating has the advantages of low thermal conductivity, high reflectivity, high wear resistance, high flame retardance and high weathering resistance.

The invention provides plastering-free mechanically-sprayed putty powder, plastering-free mechanically-sprayed putty slurry as well as a preparation method and application thereof. The plastering-freemechanically-sprayed putty powder is prepared from the following components in percentage by weight: 25.0-35.0% of an inorganic cementing material, 35.0-50.0% of aggregate, 10.0-30.0% of a filler, 1.0-3.0% of alkali-resistant additives, 3.0-5.0% of redispersible latex powder, 0.2-0.4% of hydroxypropyl methyl cellulose ether, 0.2-0.3% of anti-cracking fiber, 0.1-0.3% of a thixotropic agent, 0.05-0.15% of a water reducer and 0.01-0.05% of a water-repellent agent. The prepared plastering-free mechanically-sprayed putty has excellent bonding strength, cracking resistance, flexibility, water resistance, alkali resistance, efflorescence resistance and droop resistance, spraying constructability and scraping constructability, so that the construction efficiency is greatly improved, the construction period is shortened, and the labor cost is reduced.

Provided are a novel heterocyclic compound and salt thereof applicable in the selective inhibition of the degradation of p27Kip1. The compound and the salt thereof are represented in formula (1). [In the formula: A represents an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group, and group A can have a substituent group; ring B represents a 5- to 8- membered monocyclic heterocyclic ring or a condensed ring containing this monocyclic heterocyclic ring, and ring B can have a substituent group; ring C represents an aromatic ring, and ring C can have a substituent group; L represents a linker having 3-5 atoms in the main chain selected from carbon atoms, nitrogen atoms, oxygen atoms, and sulfur atoms, and having at least one heteroatom selected from nitrogen atoms, oxygen atoms, and sulfur atoms, and linker L can have a substituent group; and n represents 0 or 1.]

The invention discloses an ultrathin dry powder steel structure fireproof paint. The fireproof paint comprises the following components in proportion by weight: white cement, diatomite, calcined kaolin, hydrophilic silica, polyoxyethylene polyoxypropanolamine ether, polymer-modified oxidized graphene, sulfonated polybenzimidazole modified mesoporous silica, KH-560 and aeolian sand. The ultrathin dry powder steel structure fireproof paint has the advantages of excellent flame resistance, strong bonding strength, good wear resistance, excellent weatherability and water resistance, good ray proof performance, smooth and fine surface layer of the paint, and environmental protection.

The invention relates to a tile surface material composite plate and a novel construction method thereof. The construction method comprises the following steps: (1) sticking the tile surface material on a base plate to form a tile surface material spliced plate; (2) cleaning the tile surface material spliced plate; (3) forming straight-line-shaped cutting grooves on connecting seams of the tile surface material spliced plate in batches; (4) filling the cutting grooves with a crack-sealer, then curing to obtain the tile surface material composite plate and finishing the construction. The cutting grooves are formed in the modularized tile surface material composite plate in the construction method; the construction efficiency of the tile surface material composite plate can be improved, the labor intensity of the construction staff is reduced, the technological dependence of the construction staff is reduced; in addition, the butt seam precision of the tile is greatly improved, and the attractive effect of the buildings appearance is improved.

A crack sealer for white ceramic tiles comprises 10-20 parts of parts of 32.5 white cement, 20-40 parts of 400 mesh heavy calcium powder, 0.42-0.84 parts of 1# colloidal crystal, 1-2 parts of highly active silica, 1-2 parts of a bactericide, 1-3 parts of an adsorbent and 2-4 parts of a 108 adhesive. The crack sealer has the characteristics of effective prevention of erosion of molds, algae and other microbes, strong bonding force, simple components and low cost.

The invention relates to the field of buildings and particularly relates to an efficient gap filler. The efficient gap filler is prepared from the following substances in parts by weight: 35-45 parts of cement, 15-20 parts of quartz sand, 20-30 parts of washed-out sand, 8-15 parts of pulverized coal ash, 15-25 parts of redispersible organosilicone powder, 5-8 parts of inorganic pigment, 5-8 parts of hydroxyethyl methyl cellulose ether, 0.5-1.5 parts of water reducer, 0.8-1.5 parts of setting retarder, 10-15 parts of zinc chloride, 0.5-1.2 parts of redispersible latex powder, 5-10 parts of heavy calcium carbonate powder, 10-15 parts of polypropylene staple fibers, 1.5-3 parts of hydroxypropyl methylcellulose, 0.8-2.1 parts of mildew preventive, 0.8-2.0 parts of citric acid and 15-30 parts of vitrified micro bubbles. According to the efficient tile gap filler provided by the invention, the low-alkali cement is adopted as a raw material, so that the occurrence of an efforescence phenomenon can be relieved; the added citric acid can be used for effectively inhibiting the occurrence of the efforescence phenomenon; the added water reducer and setting retarder can be used for prolonging the service time of the gap filler, maintaining balance and improving viscosity; and the added vitrified micro bubbles can be used for improving warm-keeping and heat-insulating performance of the gap filler.

The invention discloses an anti-efflorescence inorganic artificial stone floor tile. The anti-efflorescence inorganic artificial stone floor tile comprises a main body mixture, dispersible rubber powder, a silane waterproof agent, cellulose ether, an ERA200 type anti-efflorescence agent and water, the dispersible rubber powder accounts for 2-4 % of the mass of the main body mixture, the ERA200 type anti-efflorescence agent accounts for 0.1-0.3% of the mass of the main body mixture, and the cellulose ether accounts for 0.01-0.05% of a cementing material. The inorganic artificial stone floor tile can effectively inhibit the surface efflorescence condition, so the long-time attractiveness of the surface of the inorganic artificial stone floor tile is effectively guaranteed; and the compressive strength of the inorganic artificial stone in the proportion reaches 120 Mpa, and the breaking strength reaches 15 Mpa, so the service life of the inorganic artificial stone floor tile can be effectively prolonged.

A novel heterocyclic compound or a salt thereof useful for selectively inhibiting the degradation of p27Kip1 is provided. The compound or the salt thereof is represented by the following formula (1), wherein A represents an alkyl group, a cycloalkyl group, an aryl group or a heterocyclic group, the group A may have a substituent; the ring B represents a 5- to 8-membered monocyclic heterocyclic ring or a condensed ring containing the monocyclic heterocyclic ring, the ring B may have a substituent; the ring C represents an aromatic ring, the ring C may have a substituent; L represents a linker comprising a main chain having 3 to 5 atoms selected from the group consisting of a carbon atom, a nitrogen atom, an oxygen atom and a sulfur atom, wherein at least one atom in the main chain is a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, the linker L may have a substituent; and n is 0 or 1.

The invention discloses radiation resistant inner wall latex paint, which is prepared from the following raw materials in parts by weight: water, a dispersing agent, a thickening agent, a wetting agent, a defoaming agent, pigment filling materials and octaphenyl caged polysilsesquioxane modified sulfonated polyimides. The invention also discloses a preparation method of the radiation resistant inner wall latex paint.

The invention discloses a radiation protection water-in-water multicolor paint. The radiation protection water-in-water multicolor paint is prepared from basic paint, protection liquid cement and an outer wrapping solution. The basic paint is prepared from, by weight, 1-5 parts of hydroxypropyl methylcellulose, 2-4 parts of glycol, 1-5 parts of dimethyl sulfoxide, 1.5-2.5 parts of nanometer titania, 15-20 parts of kaolin, 8-15 parts of tourmaline powder, 25-40 parts of octaphenyl polyhedral oligomeric silsesquioxane modified sulfonated polyimide, 0.1-0.3 part of a defoaming agent and 2-6 parts of bamboo charcoal. The protection liquid cement is prepared from, by weight, 25-50 parts of water, 0.5-0.9 part of sodium pyrophosphate, 0.15-0.25 part of lignocellulose and 1-2 parts of polyvinyl alcohol. The outer wrapping solution is prepared from, by weight, 18-28 parts of amino-end-capping sulfonated polybenzimidazole, 0.2-0.8 part of lignocellulose, 1-2 parts of glycol, 1-5 parts of dimethyl sulfoxide and 0.1-3 parts of KH-560. The invention further discloses a preparing method of the radiation protection water-in-water multicolor paint.

The invention discloses water-based anticorrosive mildewproof antirust paint. The water-based anticorrosive mildewproof antirust paint is prepared from diatomite, deionized water, polyoxyethylene polyoxypropylene ether, KH-560, polymer-modified graphene oxide and sulfonated polybenzimidazole-modified octaphenyl polyhedral oligomeric silsesquioxane-wrapped nano-silver. The water-based anticorrosive mildewproof antirust paint has the advantages of being high in adhesive force and hardness, good in fireproof property and scratch resistance, excellent in weather resistance and water resistance, good in corrosion resistance, mildew resistance and rust resistance, little in harm to a human body and pollution to the environment during preparation and the like.

The invention relates to the fields of molecular biologics and disease treatment, in particular to the field of treatment on diseases related to too low activity of PSD-95 and / or PSD-93. Specifically,the invention relates to polypeptide (or variants thereof) for treating diseases related to too low activity of PSD-95 and / or PSD-93 (such as nervous system diseases), a fusion protein with the polypeptide (or variants thereof), and application of the polypeptide (or variants thereof) and the fusion protein. The invention further relates to a medicine composition for treating or alleviating one or more symptoms of diseases related to too low activity of PSD-95 and / or PSD-93 (such as nervous system diseases), wherein the medicine composition comprises the polypeptide (or variants thereof) or the fusion protein.

The invention discloses new use of a 3, 4-broken cycloartane type triterpenoid compound. The compound is nigranoic acid or kadsuric acid, and is used in preparation of autophagy inhibitors and preparation of drugs for increasing the treatmnet sensitivity of anti-tumor drugs. The compound can be used for inhibiting ubiquitination modification of an autophagy receptor p62 and prevent activation of ap62 autophagy receptor function, and can inhibit the protective autophagy of tumor cells induced by anti-tumor drugs. The invention also provides an anti-tumor pharmaceutical composition, which comprises the 3, 4-broken cycloartane triterpenoid compound and an anti-tumor drug capable of easily causing tumor cell protective autophagy, can inhibit tumor cell growth and promote tumor cell death, andcan be used for treating cancers such as breast cancer and the like.

The invention provides high-anti-permeability bright-color mechanized spraying dry-mixed mortar. The mortar comprise the following raw materials in parts by weight: 9-19 parts of ordinary Portland white cement, 0-10 parts of mineral powder, 11-12 parts of coarse whiting powder, 0.9-1 part of pigment, 66-69 parts of fine aggregate white quartz sand, 0.33-1.32 parts of rubber powder and 0.1-0.2 partof a water reducing agent. The dry-mixed mortar disclosed by the invention is a mortar composition with advantages of excellent field constructability, sag resistance and water retaining capacity andhigh anti-permeability property, and the high-anti-permeability bright-color mechanized spraying dry-mixed mortar can maintain excellent color uniformity in adverse weather, is low in cost and can beapplied to multiple basal planes and complicated construction environments.

The invention discloses radiation-proof tunnel fireproof paint. The radiation-proof tunnel fireproof paint comprises the following components in proportion by weight of portland cement, perlite, calcined kaolin, expanded vermiculite, fly ash cenospheres, sodium alkylnaphthalenesulfonate, polydimethylsiloxane, polymer modified oxidized graphene and KH-560. The radiation-proof tunnel fireproof paint has the advantages of being excellent in fireproof performance, high in adhesive force, good in dirty resistance, high in abrasion resistance, excellent in weather resistance and water resistance, good in radiation resistance, environmental-friendly and the like.

The invention provides an alkali-inhibiting additive for pervious concrete with alkali resistance, enhancement and weather resistance and a preparation method. The alkali-inhibiting additive for pervious concrete is prepared by the following steps: pre-adding the alkali-inhibiting additive for pervious concrete into mixing water needed by a previous concrete material according to a proportion of 1-2% based on total weight of cement first and uniformly mixing the mixture; and then mixing the aqueous solution containing the alkali-inhibiting additive for pervious concrete and the previous concrete dry material uniformly to obtain the alkali-inhibiting additive for pervious concrete. The alkali-inhibiting additive for pervious concrete can inhibit saltpetering of a pervious concrete product,so that the strength of the pervious concrete product is improved, the weather resistance of the pervious concrete product is improved, and the service life of the pervious concrete is prolonged.

The invention discloses OTUD3-E86K protein as well as a coding gene and application thereof. The protein provided by the invention is (a) or (b) as follows: (a) protein consisting of amino acid sequences shown in a sequence 4 in a sequence table; (b) protein which is obtained by substitution, deletion and / or addition of one or more amino acid residues on the amino acid sequences shown in the sequence 4 in the sequence table, is same in function and is derived from the sequence 4. The experiment proves that the OTUD3-E86K protein can be used for designing or screening products for preventing and / or treating tumors, and provides important scientific basis and application values for tumor diagnosis, prevention and treatment.

Relating to the technical field of caulking agents, the invention discloses a decorative caulking agent and a preparation method thereof. The decorative caulking agent comprises the following raw materials: 55-60 parts of water absorbent resin, 45-47 parts of modified vegetable oil, 38-39 parts of waste porcelain powder, 32-33 parts of redispersible latex powder, 28-29 parts of paraffin phase change microspheres, 21-23 parts of citric acid, 15-17 parts of plant dehydrated fiber filament, 12-14 parts of a colorant, 20-23 parts of assistants and 57-65 parts of water. The decorative caulking agent provided by the invention has decorative effect and certain aesthetics, and excellent crack resistance, overcomes the shortcomings of existing caulking agents, and prolongs the service life of itself and tiles.

The invention relates to pan-alkali-resistant concrete and a preparation method thereof. Involved in the field of building materials. In parts by weight, the raw materials for the preparation of the anti-efflorescence concrete include: 8-25 parts of cement; 60-90 parts of aggregate; 2-6 parts of admixture; 0.3 parts; water; the acrylate functional agent is selected from acrylate monomers and / or acrylate polymers. The efflorescence-resistant concrete of the invention can effectively improve the efflorescence phenomenon of the concrete without affecting the compressive strength of the concrete, and at the same time, has good construction performance.

The invention relates to efflorescence-resistant concrete and a preparation method thereof, relating to the field of building materials. The efflorescence-resistant concrete is prepared from the following raw materials in parts by weight: 8-25 parts of cement; 60-90 parts of an aggregate; 2-6 parts of an admixture; 0.01-0.4 part of an acrylate functional agent, and 0.1-0.3 part of a water reducingagent; and water; wherein the acrylate functional agent is selected from acrylate monomers and / or acrylate polymers. According to the efflorescence-resistant concrete disclosed by the invention, theefflorescence phenomenon of the concrete can be effectively improved on the basis of not influencing the compressive strength of the concrete, and meanwhile, the construction performance is good.

The invention relates to a colored decorative mortar, which comprises the following raw materials in parts by weight: 500 to 600 parts of quartz sand, 80 to 120 parts of high-alumina cement, 40 to 60parts of heavy calcium carbonate powder, 120 to 150 parts of light calcium carbonate, 40 to 60 parts of hydrated lime powder, 30 to 50 parts of an admixture, and 4 to 10 parts of a pigment. The colored decorative mortar has the advantages of various colors, crack resistance, impermeability, weather resistance, durability and alkali burnout resistance and the like.

An alkali-activated fluidized bed fly ash geopolymer comprises, by mass, 250-270 parts of fluidized bed fly ash, 30-50 parts of cement, 5-18 parts of an inorganic alkali activator, 5-18 parts of an organic alkali activator and 120-140 parts of water. The fluidized bed fly ash is subjected to composite alkali excitation through the organic alkali activator and the inorganic alkali activator, so that the problem of high utilization difficulty of the fluidized bed fly ash due to complex components and low activity of the fluidized bed fly ash is effectively solved, high-dosage utilization of the fluidized bed fly ash is realized, and the mechanical properties of the prepared fluidized bed fly ash geopolymer are ensured.

The invention belongs to the field of building materials, and particularly relates to a low alkaline tile joint mixture. The low alkaline tile joint mixture is composed of the following components in mass percent: 20%-50% of cement, 20%-50% of silica sand, 0.01%-35% of coarse whiting powder, 0.01%-1.0% of redispersible powder, 0.01%-0.2% of organic silicon powder, 0.01%-0.5% of cellulose ether, 0.01%-8% of pigment, 0.01%-0.1% of retarder, and 0.01%-0.05% of citric acid. The low alkaline tile joint mixture is water-tolerant, can not crack, has good ageing-resistant performance and excellent flexibility, is firm when being bonded with a base layer, is quick-drying and quick-hardening, and can avoid the happening of the situation of saltpetering after the construction in the humid environment or cold weather.

The invention discloses OTUD3-E86K protein as well as a coding gene and application thereof. The protein provided by the invention is (a) or (b) as follows: (a) protein consisting of amino acid sequences shown in a sequence 4 in a sequence table; (b) protein which is obtained by substitution, deletion and / or addition of one or more amino acid residues on the amino acid sequences shown in the sequence 4 in the sequence table, is same in function and is derived from the sequence 4. The experiment proves that the OTUD3-E86K protein can be used for designing or screening products for preventing and / or treating tumors, and provides important scientific basis and application values for tumor diagnosis, prevention and treatment.

The invention relates to a caulking agent for ceramic tiles. The caulking agent is prepared from the following components: 10 to 20 parts of 32.5 white cement, 20 to 40 parts of 400-mesh calcium triple superphosphate powder, 0.42 to 0.84 part of 1# colloidal crystal, 1 to 2 parts of high-activity silicon dioxide, 1 to 2 parts of fungicide, 1 to 3 parts of an adsorbent, 2 to 4 parts of 108 glue and1 to 5 parts of a curing agent. The caulking agent involved in the invention can effectively prevent the erosion of microorganisms such as mildew and algae, has strong adhesive force, and has the characteristics of simple components and low cost.